{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:15:27Z","timestamp":1777554927127,"version":"3.51.4"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2012,2,1]],"date-time":"2012-02-01T00:00:00Z","timestamp":1328054400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2012,2,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Allergic contact dermatitis is considered one of the most common causes of eyelid dermatitis. In addition to metals and topical antibiotics, fragrances have emerged as a leading source of contact allergy for individuals with this condition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The objective of this study was to determine the added benefit of including a fragrance tray when patch testing patients presenting with eyelid dermatitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>During a 4.5-year period, all patients with suspected allergic contact dermatitis involving the eyelids were patch tested with both standard and fragrance trays.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred consecutive patients with eyelid dermatitis were patch tested. Of these patients, 42 (42%) tested positive for 1 or more allergens within the fragrance series. Of these patients, 15 (36%) had no fragrance markers detected on the standard series, and these allergens would therefore have been missed had fragrance series testing not been performed. Overall, fragrance markers within the standard series detected 73.2% (41\/56) of cases of fragrance allergy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Our results suggest that there may be a significant benefit to fragrance series testing in patients with eyelid dermatitis. Fragrance tray inclusion in this population may identify additional cases of fragrance allergy that are missed by the standard series.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0b013e31823d180f","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:05:37Z","timestamp":1397649937000},"page":"22-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Fragrance Series Testing in Eyelid Dermatitis"],"prefix":"10.1177","volume":"23","author":[{"given":"Kurt S.","family":"Wenk","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, The George Washington University Medical Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Ehrlich","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, The George Washington University Medical Center, Washington, DC."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2006.00927.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1600-0536.1992.tb05242.x","article-title":"Eyelid dermatitis: an evaluation of 150 patients","volume":"27","author":"Valsecchi R","year":"1992","unstructured":"Valsecchi R, , Imberti G, , Martino D, et al.. Eyelid dermatitis: an evaluation of 150 patients. Contact Dermatitis, 1992; 27: 143\u2013147.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-200306000-00004"},{"key":"e_1_3_1_5_2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1067\/mjd.2002.122736","article-title":"Eyelid dermatitis: experience in 203 cases","volume":"47","author":"Guin JD","year":"2002","unstructured":"Guin JD. Eyelid dermatitis: experience in 203 cases. J Am Acad Dermatol, 2002; 47: 755\u2013765.","journal-title":"J Am Acad Dermatol"},{"key":"e_1_3_1_6_2","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.0105-1873.2004.00311.x","article-title":"Eyelid dermatitis: a report of 215 patients","volume":"50","author":"Guin JD","year":"2004","unstructured":"Guin JD. Eyelid dermatitis: a report of 215 patients. Contact Dermatitis, 2004; 50: 87\u201390.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2007.12.004"},{"key":"e_1_3_1_8_2","first-page":"77","article-title":"Fragrance contact allergy: a 4-year retrospective study","author":"Cuesta L","unstructured":"Cuesta L, , Silvestre JF, , Toledo F, et al.. Fragrance contact allergy: a 4-year retrospective study. Contact Dermatitis 2010:, 63; 77\u201384.","journal-title":"Contact Dermatitis 2010:"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.08097"},{"key":"e_1_3_1_10_2","first-page":"11","article-title":"Contact allergic reactions on the eyes and eyelids","volume":"292","author":"Goossens A","year":"2004","unstructured":"Goossens A. Contact allergic reactions on the eyes and eyelids. Bull Soc Belge Opthalmol, 2004; 292: 11\u201317.","journal-title":"Bull Soc Belge Opthalmol"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70587-0"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00565.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2007.06041"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1999.tb06129.x"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-0536.1997.tb00418.x","article-title":"Adverse reactions to fragrances: a clinical review","volume":"36","author":"De Groot AC","year":"1997","unstructured":"De Groot AC, , Frosch J. Adverse reactions to fragrances: a clinical review. Contact Dermatitis, 1997; 36: 57\u201386.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_16_2","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0536.1995.tb00834.x","article-title":"The fragrance mix and its constituents: a 14-year material","volume":"32","author":"Johansen JD","year":"1995","unstructured":"Johansen JD, , Menne T. The fragrance mix and its constituents: a 14-year material. Contact Dermatitis, 1995; 32: 18\u201323.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_17_2","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0536.1989.tb04695.x","article-title":"Allergic reactions to fragrance mix and its components","volume":"21","author":"Malanin G","year":"1989","unstructured":"Malanin G, , Ohela K. Allergic reactions to fragrance mix and its components. Contact Dermatitis, 1989; 21: 62\u201363.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_18_2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.0105-1873.2005.00563.x","article-title":"Patch testing with a new fragrance mix\u2014reactivity to the individual constituents and chemical detection in relevant cosmetic products","volume":"52","author":"Frosch PJ","year":"2005","unstructured":"Frosch PJ, , Rastogi SC, , Pirker C, et al.. Patch testing with a new fragrance mix\u2014reactivity to the individual constituents and chemical detection in relevant cosmetic products. Contact Dermatitis, 2005; 52: 216\u2013225.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_19_2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/j.1600-0536.1991.tb01714.x","article-title":"Patch-testing with fragrance-mix and its constituents: discrepancies are largely due to the presence or absence of sorbitan sesquioleate","volume":"24","author":"Enders F","year":"1991","unstructured":"Enders F, , Przybilla B, , Ring J. Patch-testing with fragrance-mix and its constituents: discrepancies are largely due to the presence or absence of sorbitan sesquioleate. Contact Dermatitis, 1991; 24: 238\u2013239.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_20_2","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1600-0536.1995.tb00779.x","article-title":"Testing with fragrance mix\u2014is the addition of sorbitan sesquioleate to the constituents useful?","volume":"32","author":"Frosch PJ","year":"1995","unstructured":"Frosch PJ, , Pilz B, , Burrows D, et al.. Testing with fragrance mix\u2014is the addition of sorbitan sesquioleate to the constituents useful?. Contact Dermatitis, 1995; 32: 266\u2013272.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1046\/j.1365-2133.1998.02363.x","article-title":"Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals","volume":"139","author":"Johansen JD","year":"1998","unstructured":"Johansen JD, , Skov L, , Volund A, et al.. Allergens in combination have a synergistic effect on the elicitation response: a study of fragrance-sensitized individuals. Br J Dermatol, 1998; 139: 264\u2013270.","journal-title":"Br J Dermatol"},{"key":"e_1_3_1_22_2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1600-0536.1993.tb03373.x","article-title":"Frequency of false-negative reactions to the fragrance mix","volume":"28","author":"De Groot AC","year":"1993","unstructured":"De Groot AC, , Van der Klev AMJ, , Bruynzeel DP, et al.. Frequency of false-negative reactions to the fragrance mix. 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