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Known for its potential antiseptic properties, it has been shown to be active against a variety of bacteria, fungi, viruses, and mites. The oil is extracted from the leaves of the tea tree via steam distillation. This essential oil possesses a sharp camphoraceous odor followed by a menthol-like cooling sensation. Most commonly an ingredient in topical products, it is used at a concentration of 5% to 10%. Even at this concentration, it has been reported to induce contact sensitization and allergic contact dermatitis reactions. In 1999, tea tree oil was added to the North American Contact Dermatitis Group screening panel. The latest prevalence rates suggest that 1.4% of patients referred for patch testing had a positive reaction to tea tree oil.<\/jats:p>","DOI":"10.1097\/der.0b013e31823e202d","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:05:37Z","timestamp":1397649937000},"page":"48-49","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":38,"title":["Tea Tree Oil"],"prefix":"10.1177","volume":"23","author":[{"given":"David","family":"Larson","sequence":"first","affiliation":[{"name":"From the University of Southern California, Los Angeles, and the Division of Dermatology, University of California, San Diego, San Diego, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon E.","family":"Jacob","sequence":"additional","affiliation":[{"name":"From the University of Southern California, Los Angeles, and the Division of Dermatology, University of California, San Diego, San Diego, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christen M.","family":"Mowad","sequence":"additional","affiliation":[{"name":"Geisinger Medical Center Danville, PA 17821,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2012,2,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.jhin.2004.01.008","article-title":"A randomised, controlled trial of tea tree topical preparations versus a standard topical regime for the clearance of MRSA colonisation","volume":"56","author":"Dryden MS","year":"2004","unstructured":"Dryden MS, , Dailly S, , Crouch M. 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