{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:15:42Z","timestamp":1777554942394,"version":"3.51.4"},"reference-count":25,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fragrance mix II (FM II) was initiated to detect contact hypersenstitivity (CH) to fragrances that could not have been identified previously.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this multicenter study was to map the frequency of CH to FM II and its components in Hungary.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Six centers participated in the survey from 2009 to 2010. A total off 565 patients (434 women and 131 men) with former skin symptoms provoked by scented products were patch tested. The tests were performed with Brial GmbH D-Greven allergens. In the environmental patch test series, FM II, FM I,\n                      <jats:italic toggle=\"yes\">Myroxylon pereirae<\/jats:italic>\n                      , colophonium, wood-tar mix, propolis, and sesquiterpene lactone mix were tested as fragrance allergens. The FM II components (citral, farnesol, coumarin, citronellol, \u03b1-hexyl-cinnamaldehyde, and hydroxy-isohexyl-3-cyclohexene-carboxaldehyde [Lyral]) were also tested.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Contact hypersenstitivity to any fragrances was detected in 28.8%, to FM II in 17.2% of the patients. Contact hypersenstitivity to hydroxy-isohexyl-3-cyclohexene-carboxaldehyde was observed in 7.3%, to coumarin in 5.1%, to \u03b1-hexyl-cinnamaldehyde in 3.5%, to citral in 3.4%, to farnesol in 2.5%, and to citronellol in 1.2%. Of the FM II\u2013positive cases, 48.4% showed isolated CH reaction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The frequency of CH to FM II is 17.2% in the tested, selected Hungarian population. The CH to FM II and its components could not have been revealed without the present test materials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0b013e31824a6104","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:05:12Z","timestamp":1397649912000},"page":"71-74","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":11,"title":["Patch Tests With Fragrance Mix II and Its Components"],"prefix":"10.1177","volume":"23","author":[{"given":"Gy\u00f6rgyi","family":"P\u00f3nyai","sequence":"first","affiliation":[{"name":"From the *Department of Dermatology, Venerology, and Dermato-oncology, Semmelweis University, Budapest;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"N\u00e9meth","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Venerology, and Dermato-oncology, Semmelweis University, Budapest;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita","family":"Altmayer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergy of the Szent-Gy\u00f6rgyi Albert Clinical Centre, Szeged University of Sciences, Szeged;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Nagy","sequence":"additional","affiliation":[{"name":"Centre of Dermatology, Semmelweis Medical Centre of Miskolc, Miskolc;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrix","family":"Irinyi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Centre for Medicine and Medical Sciences, Faculty of General Medicine, University of Debrecen, Debrecen;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zita","family":"Batty\u00e1ni","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venerology and Dermato-oncology, P\u00e9cs Medical University, P\u00e9cs;"},{"name":"Department of Dermatology, Kaposi M\u00f3r Teaching Hospital, Kaposv\u00e1r, Hungary."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erzs\u00e9bet","family":"Temesv\u00e1ri","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Venerology, and Dermato-oncology, Semmelweis University, Budapest;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Hungarian Contact Dermatitis Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2012,4,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00563.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0105-1873.2005.00565.x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03665.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.1995.tb02048.x"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/01634989-200306000-00002"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.2310\/derm.1.2004.2030"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2009.01572.x"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2010.01759.x"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2007.06511.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470204.x"},{"issue":"1","key":"e_1_3_1_12_2","first-page":"12","article-title":"Information Network of Departments of Dermatology (IVDK): experiences with fragrance mix II\u2014the German perspective","volume":"55","author":"Geier J","year":"2006","unstructured":"Geier J, , Lessmann H, , Uter W, et al.. Information Network of Departments of Dermatology (IVDK): experiences with fragrance mix II\u2014the German perspective. 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