{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:16:28Z","timestamp":1777554988672,"version":"3.51.4"},"reference-count":9,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2013,2,1]]},"abstract":"<jats:p>\n                    Intracranial malignancies can be complicated by seizure activity, and anticonvulsants such as phenytoin are usually administered to prevent this neurological kind of complication. Cranial radiation therapy is instead the treatment of choice when the tumor is unresectable. Anyway, the combination of phenytoin and cranial radiation therapy can lead to a rare and severe mucocutaneous complication called\n                    <jats:italic toggle=\"yes\">EMPACT syndrome<\/jats:italic>\n                    . It is composed of \u201cerythema (E) multiforme (M) associated with phenytoin (P) and (A) cranial radiation (C) therapy (T).\u201d Herein, we report 2 cases of EMPACT syndrome related to the use of phenobarbital instead of phenytoin as usually described in literature.\n                  <\/jats:p>","DOI":"10.1097\/der.0b013e31827ede32","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:04:13Z","timestamp":1397649853000},"page":"37-39","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["EMPACT Syndrome Associated with Phenobarbital"],"prefix":"10.1177","volume":"24","author":[{"given":"Gabriella","family":"Fabbrocini","sequence":"first","affiliation":[{"name":"From the *Division of Clinical Dermatology, Department of Systematic Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigia","family":"Panariello","sequence":"additional","affiliation":[{"name":"From the *Division of Clinical Dermatology, Department of Systematic Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Pensabene","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Endocrinology and Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"Lauria","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Endocrinology and Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elide","family":"Matano","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Endocrinology and Oncology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donata","family":"Martellotta","sequence":"additional","affiliation":[{"name":"From the *Division of Clinical Dermatology, Department of Systematic Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Bianca","sequence":"additional","affiliation":[{"name":"From the *Division of Clinical Dermatology, Department of Systematic Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabino","family":"De Placido","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Endocrinology and Oncology, Federico II University, Naples, Italy."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Ayala","sequence":"additional","affiliation":[{"name":"From the *Division of Clinical Dermatology, Department of Systematic Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,2,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04338.x"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.01934.x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1212\/WNL.38.2.194","article-title":"Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin","volume":"38","author":"Delattre JY","year":"1988","unstructured":"Delattre JY, , Safai B, , Posner JB. Erythema multiforme and Stevens-Johnson syndrome in patients receiving cranial irradiation and phenytoin. Neurology, 1988; 38: 194\u2013198.","journal-title":"Neurology"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2002.17.2.242"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/0955300031000114738"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1995.00430210033005"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.01.017"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1046\/j.1468-3083.2003.00750.x","article-title":"The anticonvulsant hypersensitivity syndrome","volume":"17","author":"Baba M","year":"2003","unstructured":"Baba M, , Karakas M, , Aksungur VL, et al.. The anticonvulsant hypersensitivity syndrome. J Eur Acad Dermatol Venereol, 2003; 17: 399\u2013401.","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"e_1_3_1_10_2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1748-717X-5-49","article-title":"Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report","volume":"5","author":"Kandil A","year":"2010","unstructured":"Kandil A, , Dvorak T, , Mignano J, et al.. Multifocal Stevens-Johnson syndrome after concurrent phenytoin and cranial and thoracic radiation treatment, a case report. Radiat Oncol, 2010; 5: 49.","journal-title":"Radiat Oncol"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0b013e31827ede32","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1097\/DER.0b013e31827ede32","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0b013e31827ede32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:08:00Z","timestamp":1777399680000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1097\/DER.0b013e31827ede32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2,1]]}},"alternative-id":["10.1097\/DER.0b013e31827ede32"],"URL":"https:\/\/doi.org\/10.1097\/der.0b013e31827ede32","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,1]]}}}