{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T13:16:44Z","timestamp":1777555004996,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2013,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dermatitis palmaris sicca (DPS) is a common dry-fissured palmar dermatitis in Asian women. It may be an irritant contact dermatitis, but the immunophenotype of the cells in its infiltrate is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this study was to evaluate the role of inflammatory cells in the pathogenesis of DPS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patch testing was done in 68 patients with DPS, 87 subjects with hand eczema, and 31 healthy subjects. Immunophenotyping of cutaneous inflammatory cells was performed in 8 patients with DPS, 10 subjects with hand eczema, and 8 healthy individuals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Positive patch rates were higher in patients with DPS and those with hand eczema compared with healthy controls, but strong positive (++ or +++) reactions in DPS were fewer compared with hand eczema. Density of CD3\n                      <jats:sup>+<\/jats:sup>\n                      , CD4\n                      <jats:sup>+<\/jats:sup>\n                      , CD8\n                      <jats:sup>+<\/jats:sup>\n                      , and CD68\n                      <jats:sup>+<\/jats:sup>\n                      cells in skin lesions of DPS and hand eczema was significantly higher than that in normal skin. Sparse CD20\n                      <jats:sup>+<\/jats:sup>\n                      cells were present only in hand eczema. Compared with hand eczema, the number of CD3\n                      <jats:sup>+<\/jats:sup>\n                      , CD8\n                      <jats:sup>+<\/jats:sup>\n                      , CD68\n                      <jats:sup>+<\/jats:sup>\n                      , and dermal CD1a\n                      <jats:sup>+<\/jats:sup>\n                      cells decreased, but epidermal CD1a\n                      <jats:sup>+<\/jats:sup>\n                      cells and CD4\/CD8 ratio increased in DPS.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The absolute lack of CD20\n                      <jats:sup>+<\/jats:sup>\n                      cells and relative scarcity of dermal CD8\n                      <jats:sup>+<\/jats:sup>\n                      and CD1a\n                      <jats:sup>+<\/jats:sup>\n                      cells in skin lesions might be insufficient to induce contact hypersensitivity, so DPS may be an irritant but not allergic contact dermatitis.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0b013e31828ecaa7","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:03:28Z","timestamp":1397649808000},"page":"137-143","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":2,"title":["Is Dermatitis Palmaris Sicca an Irritant Contact Dermatitis?"],"prefix":"10.1177","volume":"24","author":[{"given":"Fu-Juan","family":"Chen","sequence":"first","affiliation":[{"name":"From the Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Liu","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Hua","family":"Chen","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Ming","family":"Fan","sequence":"additional","affiliation":[{"name":"From the Department of Dermatology, Affiliated Hospital of Guangdong Medical College, Zhanjiang, Guangdong, China."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,6,1]]},"reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1111\/j.1365-2230.1986.tb00507.x","article-title":"Dermatitis palmaris sicca\u2014a distinctive pattern of hand dermatitis","volume":"11","author":"Lim KB","year":"1986","unstructured":"Lim KB, , Tan T, , Rajan VS. 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Jpn Med Assoc J, 2004; 47: 44\u201351.","journal-title":"Jpn Med Assoc J"},{"key":"e_1_3_1_5_2","first-page":"75","article-title":"Clinical analysis of 62 cases of keratodermia tylodes palmaris progressive","volume":"24","author":"Wang XS","year":"1991","unstructured":"Wang XS, , Du RC. Clinical analysis of 62 cases of keratodermia tylodes palmaris progressive. Chin J Dermatol, 1991; 24: 75\u201377.","journal-title":"Chin J Dermatol"},{"key":"e_1_3_1_6_2","first-page":"1","article-title":"Abnormal expression of epidermal terminal differentiation and functional abnormalities of the stratum corneum in patients with keratoderma tylodes palmaris progressiva","volume":"17","author":"Chen YC","year":"1999","unstructured":"Chen YC, , Hsieh MY, , Chai CY, et al. Abnormal expression of epidermal terminal differentiation and functional abnormalities of the stratum corneum in patients with keratoderma tylodes palmaris progressiva. Dermatol Sin, 1999; 17: 1\u201315.","journal-title":"Dermatol Sin"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2009.0686"},{"key":"e_1_3_1_8_2","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jdermsci.2010.01.001","article-title":"Characterization of dendritic cells and macrophages in irritant contact dermatitis","volume":"57","author":"Tang H","year":"2010","unstructured":"Tang H, , Schlapbach C, , Hassan AS, et al. Characterization of dendritic cells and macrophages in irritant contact dermatitis. J Dermatol Sci, 2010; 57: 216\u2013218.","journal-title":"J Dermatol Sci"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0536.2007.01260.x","article-title":"Etiology and prognosis of hand eczema in a dermatology clinic in China: a follow-up study","volume":"58","author":"Li LF","year":"2008","unstructured":"Li LF, , Liu G, , Wang J. Etiology and prognosis of hand eczema in a dermatology clinic in China: a follow-up study. Contact Dermatitis, 2008; 58: 88\u201392.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03862.x"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09092"},{"key":"e_1_3_1_12_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.clindermatol.2011.08.019","article-title":"Abnormal epidermal barrier in the pathogenesis of contact dermatitis","volume":"30","author":"Proksch E","year":"2012","unstructured":"Proksch E, , Brasch J. Abnormal epidermal barrier in the pathogenesis of contact dermatitis. Clin Dermatol, 2012; 30: 335\u2013344.","journal-title":"Clin Dermatol"},{"key":"e_1_3_1_13_2","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1111\/j.1600-0536.2009.01621.x","article-title":"The possible relevance of sex hormones on irritant and allergic responses: their importance for skin testing","volume":"62","author":"Farage MA","year":"2010","unstructured":"Farage MA, , Berardesca E, , Maibach H. The possible relevance of sex hormones on irritant and allergic responses: their importance for skin testing. Contact Dermatitis, 2010; 62: 67\u201374.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-008-9103-3"},{"key":"e_1_3_1_15_2","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1111\/j.1523-1747.2003.12623.x","article-title":"Immunopathologic features of allergic contact dermatitis in humans: participation of plasmacytoid dendritic cells in the pathogenesis of the disease?","volume":"121","author":"Bangert C","year":"2003","unstructured":"Bangert C, , Friedl J, , Stary G, et al. Immunopathologic features of allergic contact dermatitis in humans: participation of plasmacytoid dendritic cells in the pathogenesis of the disease?. 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