{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:13:51Z","timestamp":1792088031230,"version":"4.4.0"},"reference-count":14,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Dermatitis\u00ae"],"published-print":{"date-parts":[[2013,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carba mix (CM) contains 3 chemicals used as accelerators in manufacturing of rubber products and agricultural chemicals. Iodopropynyl butylcarbamate (IPBC) is a preservative used in industrial and personal care products. Potential cross-reactivity between these allergens is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed to determine concomitant reaction rates between CM (3% petrolatum [pet]) and IPBC (0.1% pet and\/or 0.5% pet).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cross-sectional analysis of data from the North American Contact Dermatitis Group from 1998 to 2008 was conducted. Frequencies of positive reactions, strength of reactions, and concomitant reaction rates were calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 25,435 patients were tested. There were 1131 allergic reactions to CM and 346 positive reactions to IPBC (either 0.1% pet and\/or 0.5% pet). Fifty-two patients reacted to both allergens. Most reactions (&gt;69%) were doubtful\/weakly positive, and of those who reacted to both, most (58%) had doubtful and\/or weakly positive reactions. There was a statistically significant association of concomitant reactions between CM and IPBC; formaldehyde positivity was used as control and showed statistically significant concomitant reactions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Overall, concomitant reactions to CM and IPBC were low, and rates varied by strength of reaction. True cross-reactivity is unlikely; statistical association is likely due to frequent low-grade reactions to irritant patch test preparations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/der.0b013e3182a5a1d4","type":"journal-article","created":{"date-parts":[[2014,4,16]],"date-time":"2014-04-16T12:02:44Z","timestamp":1397649764000},"page":"241-245","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Positive Patch Test Reactions to Carba Mix and Iodopropynyl Butylcarbamate: Data From the North American Contact Dermatitis Group, 1998\u20132008"],"prefix":"10.1177","volume":"24","author":[{"given":"Erin M.","family":"Warshaw","sequence":"first","affiliation":[{"name":"From the *Department of Dermatology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srihari","family":"Raju","sequence":"additional","affiliation":[{"name":"From the *Department of Dermatology, Veterans Affairs Medical Center, University of Minnesota, Minneapolis, MN"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel G.","family":"DeKoven","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald V.","family":"Belsito","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn A.","family":"Zug","sequence":"additional","affiliation":[{"name":"Dartmouth-Hitchcock Medical Center, Lebanon, NH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J.","family":"Zirwas","sequence":"additional","affiliation":[{"name":"Ohio State University Medical Center, Columbus, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard I.","family":"Maibach","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California San Francisco, San Francisco, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Cleveland Clinic, Cleveland, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Sasseville","sequence":"additional","affiliation":[{"name":"Division of Dermatology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":", Jr","given":"Joseph F.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Louisville, Louisville, KY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.G. Toby","family":"Mathias","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony F.","family":"Fransway","sequence":"additional","affiliation":[{"name":"Private practice, Fort Myers, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"DeLeo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Columbia University, New York, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":", Jr","given":"James G.","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Pennsylvania State University, Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie D.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances J.","family":"Storrs","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Oregon Health Science University, Portland, OR."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,10,1]]},"reference":[{"key":"e_1_3_1_2_2","first-page":"77","article-title":"Iodopropynyl butylcarbamate","volume":"13","author":"Badreshia S","year":"2002","unstructured":"Badreshia S, , Marks JGJr. Iodopropynyl butylcarbamate. Am J Contact Dermat, 2002; 13: 77\u201379.","journal-title":"Am J Contact Dermat"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2010.09092"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2009.08097"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.2310\/derm.1.2004.2030"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2007.06060"},{"key":"e_1_3_1_7_2","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1600-0536.1997.tb02435.x","article-title":"National rates and regional differences in sensitization to allergens of the standard series. Population-adjusted frequencies of sensitization (PAFS) in 40,000 patients from a multicenter study (IVDK)","volume":"37","author":"Schnuch A","year":"1997","unstructured":"Schnuch A, , Geier J, , Uter W, et al. National rates and regional differences in sensitization to allergens of the standard series. Population-adjusted frequencies of sensitization (PAFS) in 40,000 patients from a multicenter study (IVDK). Contact Dermatitis, 1997: 37: 200\u2013209.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_8_2","first-page":"150","article-title":"Reproducibility of irritant patch test reactions to sodium lauryl sulfate in a double-blind placebo-controlled randomized study using clinical scoring","volume":"41","author":"Brasch J","year":"1999","unstructured":"Brasch J, , Becker D, , Effendy I. Reproducibility of irritant patch test reactions to sodium lauryl sulfate in a double-blind placebo-controlled randomized study using clinical scoring. Results from a study group of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG). Contact Dermatitis, 1999; 41: 150\u2013155.","journal-title":"Results from a study group of the German Contact Dermatitis Research Group (Deutsche Kontaktallergie-Gruppe, DKG). Contact Dermatitis"},{"key":"e_1_3_1_9_2","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1600-0536.1997.tb00386.x","article-title":"Crescendo reactions to sodium lauryl sulfate and retinoic acid in irritant patch tests","volume":"37","author":"L\u00f6ffler H","year":"1997","unstructured":"L\u00f6ffler H, , Effendy I. Crescendo reactions to sodium lauryl sulfate and retinoic acid in irritant patch tests. Contact Dermatitis, 1997; 37: 47\u201348.","journal-title":"Contact Dermatitis"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.480209.x"},{"issue":"2","key":"e_1_3_1_11_2","first-page":"47","article-title":"ESCD working group: European Surveillance System on Contact Allergies","volume":"51","author":"Uter W","year":"2004","unstructured":"Uter W, , Schnuch A, , Gefeller O. ESCD working group: European Surveillance System on Contact Allergies. Guidelines for the descriptive presentation and statistical analysis of contact allergy data. Contact Dermatitis, 2004; 51(2): 47\u201356.","journal-title":"Guidelines for the descriptive presentation and statistical analysis of contact allergy data. Contact Dermatitis"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06141.x"},{"key":"e_1_3_1_13_2","first-page":"26","article-title":"Threshold for occluded formaldehyde patch test in formaldehyde-sensitive patients","volume":"36","author":"Flyvholm MA","year":"1997","unstructured":"Flyvholm MA, , Hall BM, , Agner T, et al. Threshold for occluded formaldehyde patch test in formaldehyde-sensitive patients. Relationship to repeated open application test with a product containing formaldehyde releaser. Contact Dermatitis, 1997; 36: 26\u201333.","journal-title":"Relationship to repeated open application test with a product containing formaldehyde releaser. Contact Dermatitis"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.2310\/6620.2007.06053"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470204.x"}],"container-title":["Dermatitis\u00ae"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0b013e3182a5a1d4","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1097\/DER.0b013e3182a5a1d4","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1097\/DER.0b013e3182a5a1d4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T18:08:10Z","timestamp":1777399690000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.1097\/DER.0b013e3182a5a1d4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10,1]]}},"alternative-id":["10.1097\/DER.0b013e3182a5a1d4"],"URL":"https:\/\/doi.org\/10.1097\/der.0b013e3182a5a1d4","relation":{},"ISSN":["1710-3568","2162-5220"],"issn-type":[{"value":"1710-3568","type":"print"},{"value":"2162-5220","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}