{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T00:56:22Z","timestamp":1779238582359,"version":"3.51.4"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>While infrequent, nodal metastases in cutaneous squamous cell carcinoma (cSCC) can result in death from disease. Identification of those at risk for metastases is key to improved prognostication and treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To review metastatic cSCC at the study institution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS AND MATERIALS<\/jats:title>\n            <jats:p>Sixteen patients with metastatic cSCC were identified at the New York University Dermatologic Associates and Cancer Associates from 1998 to 2013. Patients were staged with American Joint Committee on Cancer (AJCC) and modified Brigham and Women's Hospital (BWH) criteria and compared to 32 control subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Seven of 16 patients were identified as Stage T2 by AJCC criteria and Stage T2b by BWH criteria; two patients were on Stage T1, three patients were on more advanced T stages, and four patients lacked primary tumor data. Five patients had hematologic malignancy, and one patient had a solid-organ transplant.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The modified BWH criteria aims to better prognosticate the large group of T2 AJCC tumors, resulting in the majority of mortality. In the experience of the authors, the majority of patients with metastatic disease were on T2, stratifying to stage T2b by BWH criteria, or more advanced T stages. The findings of this study support BWH stratification of T2 tumors and also indicate that hematologic malignancy is a significant comorbidity associated with a poor outcome.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000000798","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T23:59:19Z","timestamp":1469663959000},"page":"932-935","source":"Crossref","is-referenced-by-count":15,"title":["Metastatic Cutaneous Squamous Cell Carcinoma: The Importance of T2 Stratification and Hematologic Malignancy in Prognostication"],"prefix":"10.1097","volume":"42","author":[{"given":"Mary L.","family":"Stevenson","sequence":"first","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randie","family":"Kim","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane A.","family":"Meehan","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna C.","family":"Pavlick","sequence":"additional","affiliation":[{"name":"Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Carucci","sequence":"additional","affiliation":[{"name":"The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230816","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/jamadermatol.2015.1187","article-title":"Incidence estimate of nonmelanoma skin Cancer (Keratinocyte carcinomas) in the US population, 2012","volume":"151","author":"Rogers","year":"2015","journal-title":"JAMA Dermatol"},{"key":"R2-20230816","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/(SICI)1097-0215(19981005)78:2<144::AID-IJC3>3.0.CO;2-Z","article-title":"Trends in the incidence of non-melanocytic skin cancer (NMSC) treated in Australia 1985\u20131995: are primary prevention programs starting to have an effect?","volume":"78","author":"Staples","year":"1998","journal-title":"Int J Cancer"},{"key":"R3-20230816","first-page":"1","article-title":"Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012","author":"Karia","year":"2013","journal-title":"J Am Dermatol"},{"key":"R4-20230816","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1245\/ASO.2006.07.022","article-title":"Invasive squamous cell carcinoma of the skin: defining a high-risk group","volume":"13","author":"Mullen","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"R5-20230816","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/S1470-2045(08)70178-5","article-title":"Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study","volume":"9","author":"Brantsch","year":"2008","journal-title":"Lancet Oncol"},{"key":"R6-20230816","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1001\/jamadermatol.2013.6249","article-title":"Association of advanced leukemic stage and skin cancer tumor stage with poor skin cancer outcomes in patients with chronic lymphocytic leukemia","volume":"150","author":"Velez","year":"2014","journal-title":"JAMA Dermatol"},{"key":"R7-20230816","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1001\/jamadermatol.2013.2139","article-title":"Factors predictive of recurrence and death from cutaneous squamous cell carcinoma: a 10-year, single-institution cohort study","volume":"149","author":"Schmults","year":"2013","journal-title":"JAMA Dermatol"},{"key":"R8-20230816","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1001\/jamadermatol.2013.2456","article-title":"Evaluation of AJCC tumor staging for cutaneous squamous cell carcinoma and a proposed alternative tumor staging system","volume":"149","author":"Jambusaria-Pahlajani","year":"2013","journal-title":"JAMA Dermatol"},{"key":"R10-20230816","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jaad.2014.10.028","article-title":"Increased incidence and recurrence rates of nonmelanoma skin cancer in patients with non-Hodgkin lymphoma: a Rochester Epidemiology Project population-based study in Minnesota","volume":"72","author":"Brewer","year":"2015","journal-title":"J Am Acad Dermatol"},{"key":"R11-20230816","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/0190-9622(92)70144-5","article-title":"Prognostic factors for local recurrence, metastasis, and survival rates in squamous cell carcinoma of the skin, ear, and lip. 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