{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:33:32Z","timestamp":1793072012121,"version":"4.5.0"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>OnabotulinumtoxinA (OnabotA) injections are effective to treat palmar hyperhidrosis (HH) but are quite painful.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To evaluate efficacy and pain of OnabotA injection using a needle-free jet apparatus compared with the traditional needle injection to treat palmar HH.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>Twenty patients were recruited for a prospective open-label study. Their right hand was injected with 1% lidocaine with a jet injector, after which OnabotA was injected with a needle. The left hand was injected with OnabotA directly using the jet injector. Pain scores were recorded for both techniques. At 0, 1, 3, and 6 months, severity of palmar HH was evaluated with the Hyperhidrosis Disease Severity Scale (HDSS).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>One point reduction in the HDSS score at 1 month showed no statistical difference between both hands (<jats:italic toggle=\"yes\">p<\/jats:italic> = .451). However, the HDSS score at 1 month from baseline dropped by 1.6 for the hand treated with traditional needle injection of OnabotA compared with 1.25 for the hand treated with jet injections (<jats:italic toggle=\"yes\">p<\/jats:italic> = .031). There was no statistical difference in the pain on injection with both techniques (<jats:italic toggle=\"yes\">p<\/jats:italic> = .1925).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>This study demonstrates effective and relatively painless use of a low-pressure jet injector for OnabotA in palmar HH.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000000970","type":"journal-article","created":{"date-parts":[[2016,11,24]],"date-time":"2016-11-24T17:26:37Z","timestamp":1480008397000},"page":"264-269","source":"Crossref","is-referenced-by-count":12,"title":["Treatment of Palmar Hyperhidrosis With Needle Injection Versus Low-Pressure Needle-Free Jet Injection of OnabotulinumtoxinA: An Open-Label Prospective Study"],"prefix":"10.1097","volume":"43","author":[{"given":"Sophie","family":"Vadeboncoeur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Richer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lissa","family":"Nantel-Battista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antranik","family":"Benohanian","sequence":"additional","affiliation":[{"name":"All authors are affiliated with the Department of Medicine, Dermatology Division, H\u00f4pital Saint-Luc du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al, Montreal, Quebec"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2217\/14750708.4.3.279","article-title":"Palmar and plantar hyperhidrosis: a practical management 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