{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:25:39Z","timestamp":1786119939026,"version":"build-2736575974"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2017,7]]},"abstract":"\n BACKGROUND<\/jats:title>\n Hyaluronic acid (HA) gel fillers represent most soft tissue augmentation procedures currently used, because they have lower rates of complications compared with other materials. Many patients do not consume an entire syringe of filler but may require a retouch or intermittent augmentation after some time. The remaining material is commonly stored in a specific environment for reuse by the same patient.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE<\/jats:title>\n There are an insufficient number of recommendations concerning the safety of storing and reusing dermal fillers in the literature because of the paucity of studies. The aim of this study was to investigate the potential infectious contamination associated with the storage of HA fillers after patient treatment.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n Hyaluronic acid from previously used syringes was stored at room temperature under sterile conditions for varying durations beginning from 2009. Later, the material was submitted for panculture, including gram-positive and gram-negative bacteria, mycobacteria, and fungi.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n No fungal or mycobacterial agents were cultured from any of the samples. There were a few positive bacterial cultures, but they were predominantly contaminated with normal skin surface flora.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Although it is commonly practiced, the storage of HA fillers after initial patient injection carries a real but small risk of contamination.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/dss.0000000000001091","type":"journal-article","created":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T09:13:31Z","timestamp":1490260411000},"page":"967-970","source":"Crossref","is-referenced-by-count":8,"title":["The Sterility of Partially Used Hyaluronic Acid Fillers After Long Storage"],"prefix":"10.1097","volume":"43","author":[{"given":"Mohammed","family":"Al-Haddab","sequence":"first","affiliation":[{"name":"Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr","family":"Abduljabbar","sequence":"additional","affiliation":[{"name":"Dermatology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Al-Somaily","sequence":"additional","affiliation":[{"name":"Microbiology, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.jaad.2005.01.131","article-title":"Sterility of stored nonanimal, stabilized hyaluronic acid gel syringes after patient injection","volume":"52","author":"Bellew","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"R2-20230814","first-page":"400","article-title":"Sterility of injectable fillers containing nonanimal stabilized hyaluronic acid, hyaluronic Acid, or calcium hydroxylapatite after long-term storage","volume":"23","author":"Goulart","year":"2010","journal-title":"Cosmet Dermatol"},{"key":"R3-20230814","first-page":"1317","article-title":"Bacterial sterility of stored nonanimal stabilized hyaluronic acid-based cutaneous filler","volume":"141","author":"Bhatia","year":"2005","journal-title":"Arch Dermatol"},{"key":"R4-20230814","first-page":"22","article-title":"Safety of storing and reusing hyaluronic acid fillers: a retrospective chart review","volume":"24","author":"Safo","year":"2011","journal-title":"Cosmet Dermatol"},{"key":"R5-20230814","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/0190-9622(92)70294-P","article-title":"Sterility of refrigerated injectable collagen syringes after injection of patient","volume":"27","author":"Davis","year":"1992","journal-title":"J Am Acad Dermatol"},{"key":"R6-20230814","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1159\/000328728","article-title":"Distribution of bacteria in the epidermal layers and hair follicles of the human skin","volume":"24","author":"Lange-Asschenfeldt","year":"2011","journal-title":"Skin Pharmacol Physiol"},{"key":"R7-20230814","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1099\/0022-1317-50-7-582","article-title":"Staphylococcus epidermidis biofilms: importance and implications","volume":"50","author":"O'Gara","year":"2001","journal-title":"J Med Microbiol"},{"key":"R8-20230814","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.ajic.2004.10.001","article-title":"National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004","volume":"32","year":"2004","journal-title":"Am J Infect Control"},{"key":"R9-20230814","first-page":"1","article-title":"Guideline for hand hygiene in health-care settings. Recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPAC\/SHEA\/APIC\/IDSA Hand Hygiene Task Force. Society for Healthcare Epidemiology of America\/Association for Professionals in Infection Control\/Infectious Diseases Society of America","volume":"51","author":"Boyce","year":"2002","journal-title":"MMWR Recomm Rep"}],"container-title":["Dermatologic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00042728-201707000-00011","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:32:29Z","timestamp":1786044749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00042728-201707000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":9,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1097\/dss.0000000000001091","relation":{},"ISSN":["1076-0512","1524-4725"],"issn-type":[{"value":"1076-0512","type":"print"},{"value":"1524-4725","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}