{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T05:00:57Z","timestamp":1784696457999,"version":"3.55.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>The need for noninvasive methods in treatment of cutaneous disease has continued to evolve exponentially. Amidst the search for technologies, radiofrequency (RF) has proven efficacious in numerous skin disease processes. Although RF is well known for its cosmetic utility, its mechanism is valued in the treatment of many noncosmetic cutaneous conditions of various etiologies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To identify and describe studies in which RF was used to treat noncosmetic skin conditions and to explore the potential of this modality for further application in dermatologic diseases.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>The PubMed database was used to find relevant articles.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>This search strategy yielded 54 articles that met the eligibility criteria. Noncosmetic indications discussed in these articles include varicose veins (<jats:italic toggle=\"yes\">n<\/jats:italic> = 10,550), lymphangioma circumscriptum (<jats:italic toggle=\"yes\">n<\/jats:italic> = 72), cutaneous neoplasms (<jats:italic toggle=\"yes\">n<\/jats:italic> = 42), cutaneous leishmaniasis (<jats:italic toggle=\"yes\">n<\/jats:italic> = 743), acne and acne scarring (<jats:italic toggle=\"yes\">n<\/jats:italic> = 158), non\u2013acne scarring (<jats:italic toggle=\"yes\">n<\/jats:italic> = 43), primary axillary hyperhidrosis (<jats:italic toggle=\"yes\">n<\/jats:italic> = 76), and acute and chronic wounds (<jats:italic toggle=\"yes\">n<\/jats:italic> = 94).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Treatment with RF is an effective, generally noninvasive modality with a relatively short postprocedure recovery time and little potential for severe adverse effects in the treatment of several cutaneous conditions. Further clinical studies would prove useful to assess the efficacy and cost-effectiveness of this treatment.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000001925","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T03:17:23Z","timestamp":1553483843000},"page":"908-930","source":"Crossref","is-referenced-by-count":17,"title":["Radiofrequency Therapy and Noncosmetic Cutaneous Conditions"],"prefix":"10.1097","volume":"45","author":[{"given":"Chloe","family":"Ekelem","sequence":"first","affiliation":[{"name":"Department of Dermatology, University of California, Irvine, Irvine, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Logan","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Irvine, Irvine, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Van Hal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Irvine, Irvine, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Valdebran","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, Irvine, Irvine, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Lotfizadeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of California, San Francisco, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karolina","family":"Mlynek","sequence":"additional","affiliation":[{"name":"Dermatology and Plastic Surgery Institute, Cleveland Clinic, Cleveland, Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Atanaskova","family":"Mesinkovska","sequence":"additional","affiliation":[{"name":"Department of Dermatology, 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