{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:43:03Z","timestamp":1790286183372,"version":"4.1.0"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Demand for noninvasive body contouring has increased.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>We evaluated the efficacy and safety of a thermal high-intensity focused ultrasound (HIFU) device for abdominal body shaping.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS AND METHODS<\/jats:title>\n            <jats:p>Adults with a body mass index \u226430 kg\/m<jats:sup>2<\/jats:sup> and an abdominal subcutaneous fat tissue thickness \u22652.5 cm were enrolled for HIFU treatment at energy levels of 150 J\/cm<jats:sup>2<\/jats:sup> (first session) and 135 J\/cm<jats:sup>2<\/jats:sup> (second session). The primary end point was a change from baseline waist circumference at post\u2010treatment Week 8. Secondary efficacy end points were: changes in body weight, waist\/hip ratio, and fat thickness assessed by ultrasound, caliper, and a fat CT scan. The Global Aesthetic Improvement Scale was evaluated by both investigators and subjects.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>The primary assessment achieved statistical significance, showing a reduction of 3.43 cm in mean waist circumference. The treatment effect was cumulative, with a steady decrease in waist circumference and fat thickness. The mean pain scores immediately after treatment were 4.45 \u00b1 2.74 on a scale of 1 to 10 with 10 being the most painful, which decreased to 1.10 \u00b1 1.33 after 1 week.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>High-intensity focused ultrasound is an effective and safe treatment modality for reducing waist circumference in nonobese individuals with focal fat accumulation.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000002016","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T10:08:55Z","timestamp":1567678135000},"page":"213-219","source":"Crossref","is-referenced-by-count":38,"title":["Efficacy and Safety of High-Intensity Focused Ultrasound for Noninvasive Abdominal Subcutaneous Fat Reduction"],"prefix":"10.1097","volume":"46","author":[{"given":"Ji Yeon","family":"Hong","sequence":"first","affiliation":[{"name":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Jung","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Dermatology, National Police Hospital, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Young","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Rin","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Clinical development team, Classys Inc., Seoul, Korea."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beom Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Chung-Ang University College of Medicine, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1111\/jdv.12994","article-title":"Non-invasive subcutaneous fat reduction: a review","volume":"29","author":"Kennedy","year":"2015","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R2-20230814","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/PRS.0b013e3182174278","article-title":"Randomized sham-controlled trial to evaluate the safety and effectiveness of a high-intensity focused ultrasound device for noninvasive body sculpting","volume":"128","author":"Jewell","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"R3-20230814","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00266-010-9503-0","article-title":"High-intensity focused ultrasound effectively reduces waist circumference by ablating adipose tissue from the abdomen and flanks: a retrospective case series","volume":"34","author":"Fatemi","year":"2010","journal-title":"Aesthet Plast Surg"},{"key":"R4-20230814","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/DSS.0000000000000918","article-title":"A multicenter controlled study to evaluate multiple treatments with nonthermal focused ultrasound for noninvasive fat reduction","volume":"43","author":"Coleman","year":"2017","journal-title":"Dermatol Surg"},{"key":"R5-20230814","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1111\/dsu.12269","article-title":"Noninvasive lipoma size reduction using high-intensity focused ultrasound","volume":"39","author":"Shemer","year":"2013","journal-title":"Dermatol Surg"},{"key":"R6-20230814","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/srt.12319","article-title":"Improved methods for evaluating pre-clinical and histological effects of subcutaneous fat reduction using high-intensity focused ultrasound in a porcine model","volume":"23","author":"Kwon","year":"2017","journal-title":"Skin Res Technol"},{"key":"R7-20230814","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/lsm.22544","article-title":"The safety and efficacy of thermal lipolysis of adipose tissue via ultrasound for circumference reduction: an open label, single-arm exploratory study","volume":"48","author":"Otto","year":"2016","journal-title":"Lasers Surg Med"},{"key":"R8-20230814","first-page":"641","article-title":"High-intensity focused ultrasound for the reduction of subcutaneous adipose tissue using multiple treatment techniques","volume":"40","author":"Robinson","year":"2014","journal-title":"Dermatol Surg"},{"key":"R9-20230814","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/jdv.13713","article-title":"Tightening effects of high-intensity focused ultrasound on body skin and subdermal tissue: a pilot study","volume":"30","author":"Choi","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R10-20230814","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/j.1524-4725.2012.02338.x","article-title":"Noninvasive lifting of arm, thigh, and knee skin with transcutaneous intense focused ultrasound","volume":"38","author":"Alster","year":"2012","journal-title":"Dermatol Surg"},{"key":"R11-20230814","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1524-4725.2011.02148.x","article-title":"A randomized, single-blind, postmarketing study of multiple energy levels of high-intensity focused ultrasound for noninvasive body sculpting","volume":"38","author":"Solish","year":"2012","journal-title":"Dermatol Surg"},{"key":"R12-20230814","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/lsm.22232","article-title":"Efficacy of high-intensity focused ultrasonography for noninvasive body sculpting in Chinese patients","volume":"46","author":"Shek","year":"2014","journal-title":"Lasers Surg Med"},{"key":"R13-20230814","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1177\/1090820X12455190","article-title":"Safety and tolerability of high-intensity focused ultrasonography for noninvasive body sculpting: 24-week data from a randomized, sham-controlled study","volume":"32","author":"Jewell","year":"2012","journal-title":"Aesthet Surg J"},{"key":"R14-20230814","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1177\/1090820X11405027","article-title":"Evaluation of a novel high-intensity focused ultrasound device for ablating subcutaneous adipose tissue for noninvasive body contouring: safety studies in human volunteers","volume":"31","author":"Gadsden","year":"2011","journal-title":"Aesthet Surg J"},{"key":"R15-20230814","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/srt.12371","article-title":"Efficacy and safety of non-invasive body tightening with high-intensity focused ultrasound (HIFU)","volume":"23","author":"Ko","year":"2017","journal-title":"Skin Res Technol"},{"key":"R16-20230814","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.sder.2009.11.005","article-title":"High-intensity focused ultrasound effectively reduces adipose tissue","volume":"28","author":"Fatemi","year":"2009","journal-title":"Semin Cutan Med Surg"},{"key":"R17-20230814","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1253\/circj.CJ-09-0161","article-title":"Waist circumference and waist-to-height ratio as predictors of cardiovascular disease risk in Korean adults","volume":"73","author":"Park","year":"2009","journal-title":"Circ J"},{"key":"R18-20230814","first-page":"433","article-title":"Prospective study of optimal obesity index cutoffs for predicting development of multiple metabolic risk factors: the Korean genome and epidemiology study","volume":"22","author":"Ko","year":"2012","journal-title":"J Epidemiol"},{"key":"R19-20230814","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/ejcn.2009.71","article-title":"Waist circumference and waist\/hip ratio in relation to all-cause mortality, cancer and sleep apnea","volume":"64","author":"Seidell","year":"2010","journal-title":"Eur J Clin Nutr"}],"container-title":["Dermatologic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000002016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T19:44:02Z","timestamp":1692042242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000002016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/dss.0000000000002016","relation":{},"ISSN":["1076-0512","1524-4725"],"issn-type":[{"value":"1076-0512","type":"print"},{"value":"1524-4725","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2]]}}}