{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T04:51:16Z","timestamp":1769921476761,"version":"3.49.0"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>The Mohs Appropriate Use Criteria (MAUC) have come into question recently regarding the most appropriate treatment for superficial basal cell carcinoma (sBCC). At the heart of this debate is the limited body of evidence describing tumor behavior of sBCC based on clinical factors relevant to the MAUC.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To determine whether sBCC is more likely to harbor aggressive subtypes in high-risk anatomical locations and in immunocompromised patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>A single institution retrospective review produced 133 evaluable Mohs cases performed on sBCC over a 10-year period. All slides from the respective cases were reviewed for the presence of histologic patterns other than known sBCC. Cases were then grouped by both MAUC anatomical zone (H, M, and L) and patient immune status for statistical analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>A significantly higher rate of mixed histology (MH) was observed when comparing Zone H with Zone L across all patients, healthy patients, and immunocompromised patients. The same was true when comparing Zone M with Zone L for all patients and healthy patients (immunocompromised did not reach significance).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The authors' data very clearly demonstrate a higher rate of MH in sBCC of the head and neck which provides strong support to the current MAUC scoring.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000002162","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T16:11:18Z","timestamp":1572019878000},"page":"747-751","source":"Crossref","is-referenced-by-count":9,"title":["Superficial Basal Cell Cancers Demonstrate Higher Rates of Mixed Histology on High-Risk Anatomical Sites"],"prefix":"10.1097","volume":"46","author":[{"given":"Erik T.","family":"Petersen","sequence":"first","affiliation":[{"name":"Departments of Dermatology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saqib R.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Departments of Dermatology,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dinesh","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Anatomical Pathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah F.","family":"MacFarlane","sequence":"additional","affiliation":[{"name":"Departments of Dermatology,"},{"name":"Plastic Surgery, University of Texas MD Anderson Cancer Center, Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jaad.2012.06.009","article-title":"AAD\/ACMS\/ASDSA\/ASMS 2012 appropriate use criteria for Mohs micrographic surgery: a report of the American Academy of Dermatology, American College of Mohs surgery, American Society for Dermatologic Surgery Association, and the American Society for Mohs surgery","volume":"67","author":"Force","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"R2-20230814","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1001\/jamadermatol.2018.0111","article-title":"Reevaluating Mohs surgery appropriate use criteria for primary superficial basal cell carcinoma","volume":"154","author":"Steinman","year":"2018","journal-title":"JAMA Dermatol"},{"key":"R3-20230814","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1001\/jamadermatol.2018.5661","article-title":"Mohs appropriate use criteria for superficial basal cell carcinoma","volume":"155","author":"MacFarlane","year":"2019","journal-title":"JAMA Dermatol"},{"key":"R4-20230814","first-page":"542","article-title":"Basal cell carcinoma with mixed histology: a possible pathogenesis for recurrent skin cancer","volume":"32","author":"Cohen","year":"2006","journal-title":"Dermatol Surg"},{"key":"R5-20230814","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4103\/0019-5154.123496","article-title":"Characteristics of mixed type basal cell carcinoma in comparison to other BCC subtypes","volume":"59","author":"Ghanadan","year":"2014","journal-title":"Indian J Dermatol"},{"key":"R6-20230814","first-page":"222","article-title":"Basal cell carcinoma of the skin with mixed histomorphology: a comparative study","volume":"52","author":"Barto\u0161","year":"2016","journal-title":"Cesk Patol"},{"key":"R7-20230814","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1468-3083.2012.04695.x","article-title":"Diagnostic accuracy of punch biopsy in subtyping basal cell carcinoma","volume":"28","author":"Kamyab\u2010Hesari","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R8-20230814","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1001\/jamadermatol.2018.5664","article-title":"Mohs appropriate use criteria for superficial basal cell carcinoma\u2014reply","volume":"155","author":"Steinman","year":"2019","journal-title":"JAMA Dermatol"}],"container-title":["Dermatologic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000002162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T19:49:02Z","timestamp":1692042542000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000002162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,24]]},"references-count":8,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1097\/dss.0000000000002162","relation":{},"ISSN":["1076-0512","1524-4725"],"issn-type":[{"value":"1076-0512","type":"print"},{"value":"1524-4725","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,24]]}}}