{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:48:06Z","timestamp":1791895686244,"version":"4.3.4"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Acne scarring occurs at a young age and causes distress for many patients. Various treatment modalities have been tried.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>This study investigated the efficacy of combination therapy with topical poly-lactic acid and microneedle fractional radiofrequency (MFRF) for acne scars.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>Patients with acne scars on both the cheeks were included. Poly-lactic acid was applied to the acne scars on one side of the face before MFRF treatment. The other side of the face was treated with MFRF and normal saline. Patients received 3 treatment sessions and were evaluated based on visual assessment and patient satisfaction. After the last treatment, objective scar assessment of scar smoothness, size, brightness, and overall improvement was performed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Both acne scar assessment scores and patient satisfaction were better with combination therapy (<jats:italic toggle=\"yes\">p<\/jats:italic> = .036 and <jats:italic toggle=\"yes\">p<\/jats:italic> = .009, respectively) than with monotherapy. Combination therapy resulted in significantly better efficacy for scar smoothness (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; .001), scar size (<jats:italic toggle=\"yes\">p<\/jats:italic> = .003), and overall improvement (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; .001), but not for brightness (<jats:italic toggle=\"yes\">p<\/jats:italic> = .151).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Combination therapy resulted in significantly better clinical outcomes, including better scar smoothness and smaller scar size. Therefore, we believe this combination therapy is a safe and effective treatment for acne scars.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000002175","type":"journal-article","created":{"date-parts":[[2019,10,7]],"date-time":"2019-10-07T20:22:23Z","timestamp":1570479743000},"page":"796-802","source":"Crossref","is-referenced-by-count":38,"title":["Combination Therapy of Microneedle Fractional Radiofrequency and Topical Poly-Lactic Acid for Acne Scars: A Randomized Controlled Split-Face Study"],"prefix":"10.1097","volume":"46","author":[{"given":"Min K.","family":"An","sequence":"first","affiliation":[{"name":"Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun H.","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk B.","family":"Suh","sequence":"additional","affiliation":[{"name":"SeoASong Dermatologic Clinic, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun J.","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang H.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology, College of Medicine, Hallym University, Anyang, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1136\/bmj.326.7380.88","article-title":"Skin 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(3-hydroxybutyrate-co-3-hydroxyvalerate)(PHB\/VA)","volume":"27","author":"Gogolewski","year":"1993","journal-title":"J Biomed Mater Res"},{"key":"R14-20230814","doi-asserted-by":"crossref","first-page":"447","DOI":"10.5021\/ad.2014.26.4.447","article-title":"The efficacy, longevity, and safety of combined radiofrequency treatment and hyaluronic Acid filler for skin rejuvenation","volume":"26","author":"Kim","year":"2014","journal-title":"Ann Dermatol"},{"key":"R15-20230814","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/14764172.2014.968579","article-title":"Correction of midface volume deficiency using hyaluronic acid filler and intradermal radiofrequency","volume":"17","author":"Ko","year":"2015","journal-title":"J Cosmet Laser Ther"},{"key":"R16-20230814","doi-asserted-by":"crossref","first-page":"6939018","DOI":"10.1155\/2016\/6939018","article-title":"Thermal response of in vivo human skin to fractional radiofrequency microneedle 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