{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T02:55:31Z","timestamp":1768618531488,"version":"3.49.0"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"11","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Pigmented lesions from chronic UV photoaging are extremely common on the face and hands.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>To evaluate the safety and efficacy of a 532-nm picosecond laser for these types of pigmented lesions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>METHODS<\/jats:title>\n            <jats:p>This was a single-center, prospective, open-label clinical trial. Eligible subjects with pigmentation on the face and hands received 3 monthly treatments, with 1 month (1M) and 3 months (3M) follow-up. Change in investigator-graded overall facial and per lesion pigmentation and subject-graded satisfaction and pigmentation improvement was evaluated by a 5-point scale. Immediate skin response and adverse events (AEs) were evaluated post-treatment. The melanin index was measured using a mexameter. Randomized before and after photographs were graded by 3 blinded physicians for degree of pigmentation improvement.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Twenty-five subjects (22F\/3M) with Fitzpatrick skin types I-III were enrolled, with 23 subjects completing. Treatments used a 532 nm wavelength, 800 ps pulse duration, 4-6mm spot size, and 0.1 to 0.6J\/cm2 fluence. Good-to-excellent clearance at 1M\/3M was demonstrated in \u226595% of lesions (n = 116). Only mild treatment-related pain was reported, with transient post-treatment AEs (mean downtime of 2.1 \u00b1 2.0 days) and no serious treatment-related AEs. Subject satisfaction (satisfied or very satisfied) was 95% at 1M and 91% at 3M.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Treatment with a 532-nm picosecond laser is safe and highly effective for the treatment of the pigmented lesions of the face and dorsal hands.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000003602","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T09:02:45Z","timestamp":1667811765000},"page":"1215-1219","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Prospective Study of 532-nm Picosecond Laser for the Treatment of Pigmented Lesions of the Face and Dorsal Hands"],"prefix":"10.1097","volume":"48","author":[{"given":"Daniel P.","family":"Friedmann","sequence":"first","affiliation":[{"name":"Westlake Dermatology Clinical Research Center, Westlake Dermatology and Cosmetic Surgery, Austin, Texas;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Lumenis Ltd, Yokneam, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoya","family":"Cahana","sequence":"additional","affiliation":[{"name":"Lumenis Ltd, Yokneam, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2022,10,18]]},"reference":[{"key":"R1-20250731","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/lsm.20222","article-title":"Split treatment of photodamaged skin with KTP 532 nm laser with 10 mm handpiece versus IPL: a cheek-to-cheek comparison","volume":"38","author":"Butler","year":"2006","journal-title":"Lasers Surg Med"},{"key":"R2-20250731","first-page":"1398","article-title":"Evaluation of the safety and efficacy of a low fluence, picopulsed, alexandrite laser in a pico-toning 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