{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T05:01:14Z","timestamp":1789189274807,"version":"build-2803163510"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Limited data exist for the efficacy of topical 5-fluorouracil (5-FU) and imiquimod for cutaneous squamous cell carcinoma (cSCC) in situ (cSCCis) with positive histologic margins at the time of diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>Identify the efficacy of topical 5-FU and imiquimod in the treatment of cSCCis with positive histologic margins at the time of diagnosis in relation to clinical risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>Pathology records were screened at a single institution from 2014 to 2021 for cSCCis with positive histologic margins. Patients were included if they were treated with curative intent with topical 5-FU or imiquimod. Recurrences were evaluated in relation to multiple clinical risk factors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Of 215 patients treated with 5-FU or imiquimod after biopsy-proven cSCCis, 19 patients had recurrent cSCCis and 1 patient had upstaging to invasive cSCC. Recurrence was more likely in larger lesions at the time of initial biopsy (<jats:italic toggle=\"yes\">p<\/jats:italic> = .033) and in patients treated with topical imiquimod compared with topical 5-FU (<jats:italic toggle=\"yes\">p<\/jats:italic> &lt; .01).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Topical 5-FU is an appropriate therapy for cSCCis in the correct clinical scenario. Extra consideration should be taken for use of 5-FU in larger diameter cSCCis lesions. Although limited by sample size, our study does not support the use of imiquimod for cSCCis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000004044","type":"journal-article","created":{"date-parts":[[2023,12,4]],"date-time":"2023-12-04T13:00:21Z","timestamp":1701694821000},"page":"219-223","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Topical Treatment of Cutaneous Squamous Cell Carcinoma in Situ and the Impact of Clinical Risk Factors and Positive Histologic Margins at the Time of Diagnosis"],"prefix":"10.1097","volume":"50","author":[{"given":"Brandon J.","family":"Calley","sequence":"first","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, Wisconsin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin","family":"Fazio","sequence":"additional","affiliation":[{"name":"Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjishnu","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Medical College of Wisconsin, Milwaukee, Wisconsin;"},{"name":"Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"R1-20250731","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/S0190-9622(08)81509-5","article-title":"Nonmelanoma skin cancer in the United States: incidence","volume":"30","author":"Miller","year":"1994","journal-title":"J Am Acad Dermatol"},{"key":"R2-20250731","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.jaad.2012.11.037","article-title":"Cutaneous squamous cell carcinoma: estimated incidence of disease, nodal metastasis, and deaths from disease in the United States, 2012","volume":"68","author":"Karia","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"R3-20250731","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1097\/DSS.0000000000001581","article-title":"Measuring the depth of perineural invasion in cutaneous squamous cell carcinoma: implications on biopsy technique","volume":"44","author":"Tang","year":"2018","journal-title":"Dermatol Surg"},{"key":"R4-20250731","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1001\/archderm.142.6.755","article-title":"Special concern about squamous cell carcinoma of the scalp in organ transplant recipients","volume":"142","author":"Cooper","year":"2006","journal-title":"Arch 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Dermatol"},{"key":"R10-20250731","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jaad.2006.04.004","article-title":"Imiquimod 5% cream in the treatment of Bowen's disease and invasive squamous cell carcinoma","volume":"55","author":"Peris","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"R11-20250731","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1111\/j.1524-4725.2011.02088.x","article-title":"Treatment of squamous cell carcinoma in situ: a review","volume":"37","author":"Shimizu","year":"2011","journal-title":"Dermatol Surg"},{"key":"R12-20250731","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.bjps.2018.03.019","article-title":"A 5-year follow-up study of 633 cutaneous SCC excisions: rates of local recurrence and lymph node metastasis","volume":"71","author":"Khan","year":"2018","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"R13-20250731","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.jaad.2021.08.045","article-title":"Topical 5% 5-fluorouracil versus procedural modalities for squamous cell carcinoma in situ and superficial basal cell carcinoma: a retrospective cohort analysis","volume":"87","author":"Neale","year":"2022","journal-title":"J Am Acad Dermatol"}],"container-title":["Dermatologic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000004044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,31]],"date-time":"2025-07-31T22:07:55Z","timestamp":1753999675000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000004044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,30]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/dss.0000000000004044","relation":{},"ISSN":["1076-0512","1524-4725"],"issn-type":[{"value":"1076-0512","type":"print"},{"value":"1524-4725","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,30]]}}}