{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T04:17:03Z","timestamp":1743394623206,"version":"3.40.3"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Pruritus and pain symptoms secondary to hypertrophic scars (HTSs) are associated with multiple factors, with age, body mass index (BMI), and scar thickness being the main risk factors (RFs).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>This study mainly discusses the clinical symptoms associated with postburn HTSs and analyzes RFs for itching and pain requiring pharmacological intervention.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MATERIALS AND METHODS<\/jats:title>\n            <jats:p>All clinical data of 93 patients with postburn HTSs who visited the Burn Department of Shanghai Seventh People's Hospital between January 1, 2021 and January 1, 2023 were collected and analyzed retrospectively. Referring to the University of North Carolina \u201c4P\u201d Scar Scale, patients were rated as either \u201cwith\u201d or \u201cwithout\u201d according to whether they had \u201cscar itching symptoms requiring pharmacological intervention.\u201d<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>Smoking, third-degree burns, unused silicone drugs, and total burn surface area 30% to 50% were independent RFs for requiring pharmacological intervention for postburn scar pruritus (odds ratio [OR] = 2.998, 3.924, 3.588, and 5.965, <jats:italic toggle=\"yes\">p<\/jats:italic> &lt; .05). Age, increased BMI, greater scar thickness, and duration of hyperplasia not more than 1 year significantly increased the risk of scar pain requiring medical intervention (OR = 1.626, 2.441, 20.830, 11.646, and 11.136, <jats:italic toggle=\"yes\">p<\/jats:italic> &lt; .05).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>The clinical value of these factors is that they can help physicians better identify those patients who may require pharmacological intervention to control itching and pain.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/dss.0000000000004516","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T13:05:01Z","timestamp":1734354301000},"page":"396-402","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Clinical Symptoms of Postburn Hypertrophic Scars and Analysis of Risk Factors for Itching and Pain Requiring Pharmacological Intervention"],"prefix":"10.1097","volume":"51","author":[{"given":"Bo","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YaoHui","family":"Gu","sequence":"additional","affiliation":[{"name":"All authors are affiliated with the Department of Burn and Plastic Surgery, Shanghai Seventh People's Hospital, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"R1-20250328","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41572-020-0145-5","article-title":"Burn injury","volume":"6","author":"Jeschke","year":"2020","journal-title":"Nat Rev Dis Primers"},{"key":"R2-20250328","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s41038-019-0163-2","article-title":"Understanding acute burn injury as a chronic disease","volume":"7","author":"Barrett","year":"2019","journal-title":"Burns Trauma"},{"key":"R3-20250328","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/jbcr\/iraa154","article-title":"Trends in burn injuries in Northern Israel during the COVID-19 lockdown","volume":"42","author":"Kruchevsky","year":"2021","journal-title":"J Burn Care"},{"key":"R4-20250328","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.burns.2018.12.011","article-title":"Epidemiology and outcomes of burn injuries at a tertiary burn care center in Bangladesh","volume":"45","author":"Bailey","year":"2019","journal-title":"Burns"},{"key":"R5-20250328","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/B978-1-4377-2786-9.00003-5","article-title":"Epidemiological, demographic, and outcome characteristics of burn injury","volume":"4","author":"Pruitt","year":"2012","journal-title":"Total Burn Care"},{"key":"R6-20250328","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1097\/SLA.0000000000002722","article-title":"Increased rate of long-term mortality among burn survivors: a population-based matched cohort study","volume":"269","author":"Mason","year":"2019","journal-title":"Ann Surg"},{"key":"R7-20250328","doi-asserted-by":"crossref","first-page":"e0226653","DOI":"10.1371\/journal.pone.0226653","article-title":"Recovery of health-related quality of life after burn injuries: an individual participant data meta-analysis","volume":"15","author":"Spronk","year":"2020","journal-title":"PLoS One"},{"key":"R9-20250328","doi-asserted-by":"crossref","first-page":"897","DOI":"10.3390\/ijms22020897","article-title":"Molecular changes underlying hypertrophic scarring following burns involve specific deregulations at all wound healing stages (inflammation, proliferation and maturation)","volume":"22","author":"\u010coma","year":"2021","journal-title":"Int J Mol Sci"},{"key":"R10-20250328","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0305-4179(03)00067-6","article-title":"What is the prevalence of hypertrophic scarring following burns?","volume":"29","author":"Bombaro","year":"2003","journal-title":"Burns"},{"key":"R11-20250328","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1007\/s13555-013-0036-8","article-title":"Efficacy and safety of an advanced formula silicone gel for prevention of post-operative scars","volume":"3","author":"Medhi","year":"2013","journal-title":"Dermatol Ther"},{"key":"R12-20250328","doi-asserted-by":"crossref","first-page":"tkz003","DOI":"10.1093\/burnst\/tkz003","article-title":"Strategies to prevent hypertrophic scar formation: a review of therapeutic interventions based on molecular evidence","volume":"8","author":"Shirakami","year":"2020","journal-title":"Burns Trauma"},{"key":"R13-20250328","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1111\/jocd.14310","article-title":"Update on management of keloid and hypertrophic scars: a systemic review","volume":"20","author":"Elsaie","year":"2021","journal-title":"J Cosmet Dermatol"},{"key":"R15-20250328","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1111\/wrr.12432","article-title":"Current concepts related to hypertrophic scarring in burn injuries","volume":"24","author":"Chiang","year":"2016","journal-title":"Wound Repair Regen"},{"key":"R16-20250328","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2017.09.018","article-title":"Burn injury: challenges and advances in burn wound healing, infection, pain and scarring","volume":"123","author":"Wang","year":"2018","journal-title":"Adv Drug Deliv Rev"},{"key":"R17-20250328","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.burns.2017.05.006","article-title":"Scar massage for hypertrophic burns scarring\u2014a systematic review","volume":"44","author":"Ault","year":"2018","journal-title":"Burns"},{"key":"R18-20250328","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13054-015-0961-2","article-title":"Burn wound healing and treatment: review and advancements","volume":"19","author":"Rowan","year":"2015","journal-title":"Crit Care"},{"key":"R19-20250328","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00238-011-0661-3","article-title":"Smoking and its effect on scar healing","volume":"35","author":"Deliaert","year":"2012","journal-title":"Eur J Plast Surg"},{"key":"R20-20250328","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bjps.2015.11.015","article-title":"Currently known risk factors for hypertrophic skin scarring: a review","volume":"69","author":"Butzelaar","year":"2016","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"R21-20250328","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1097\/BCR.0b013e3182223c32","article-title":"Update on pruritic mechanisms of hypertrophic scars in postburn patients: the potential role of opioids and their receptors","volume":"32","author":"Cheng","year":"2011","journal-title":"J Burn Care Res"},{"key":"R22-20250328","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/BCR.0b013e318257db36","article-title":"The use of laser Doppler imaging as a predictor of burn depth and hypertrophic scar postburn injury","volume":"33","author":"Stewart","year":"2012","journal-title":"J Burn Care Res"},{"key":"R23-20250328","doi-asserted-by":"crossref","first-page":"tkab004","DOI":"10.1093\/burnst\/tkab004","article-title":"Obstruction of the formation of granulation tissue leads to delayed wound healing after scald burn injury in mice","volume":"9","author":"Chen","year":"2021","journal-title":"Burns Trauma"},{"key":"R24-20250328","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3109\/2000656X.2012.669184","article-title":"Formation of hypertrophic scars: evolution and susceptibility","volume":"46","author":"Mahdavian Delavary","year":"2012","journal-title":"J Plast Surg Hand Surg"},{"key":"R25-20250328","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.burns.2021.08.007","article-title":"Analysis of the predictors of hypertrophic scarring pain and neuropathic pain after burn","volume":"48","author":"Shu","year":"2022","journal-title":"Burns"},{"key":"R26-20250328","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/wrr.12637","article-title":"Risk factors for hypertrophic burn scar pain, pruritus, and paresthesia development","volume":"26","author":"Xiao","year":"2018","journal-title":"Wound Repair Regen"},{"key":"R27-20250328","doi-asserted-by":"crossref","first-page":"428","DOI":"10.5021\/ad.2013.25.4.428","article-title":"Clinical and histological correlation in post-burn hypertrophic scar for pain and itching sensation","volume":"25","author":"Choi","year":"2013","journal-title":"Ann Dermatol"}],"container-title":["Dermatologic Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000004516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,30]],"date-time":"2025-03-30T18:21:59Z","timestamp":1743358919000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/DSS.0000000000004516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/dss.0000000000004516","relation":{},"ISSN":["1076-0512","1524-4725"],"issn-type":[{"type":"print","value":"1076-0512"},{"type":"electronic","value":"1524-4725"}],"subject":[],"published":{"date-parts":[[2024,12,16]]}}}