{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T04:58:40Z","timestamp":1785301120286,"version":"3.55.0"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Dermatol Surg","DS"],"published-print":{"date-parts":[[2026,8]]},"abstract":"\n BACKGROUND<\/jats:title>\n Aging leads to noticeable changes in lip volume, definition, and projection largely due to alterations in the orbicularis oris muscle. Although superficial signs of aging are well-documented, deeper muscular changes remain underexplored. These anatomical shifts can influence both lip aesthetics and the effectiveness of interventions such as dermal fillers and botulinum toxin.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE<\/jats:title>\n This study aimed to evaluate age-related changes in the angle of the orbicularis oris muscle and to examine potential sex-based differences.<\/jats:p>\n <\/jats:sec>\n \n MATERIALS AND METHODS<\/jats:title>\n Thirty healthy participants (17 women and 13 men), aged 20 to 60 years, with normal body mass index (18.5\u201324.9), were enrolled. None of the patients had any history of lip surgery or injections. Using high-resolution ultrasonography, the angle of the orbicularis oris muscle was measured at 5 standardized anatomical points on both the upper and lower lips.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n A significant decrease in the muscle angle was observed with age, particularly in female participants. These changes were most pronounced in the upper lip and associated with a more inverted lip shape.<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n Age-related changes in the orbicularis oris muscle, especially in female participants, contribute to altered lip morphology. Understanding these changes can help develop more effective and natural rejuvenation strategies using injectables.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/dss.0000000000005035","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T14:00:44Z","timestamp":1769608844000},"page":"761-764","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Age-Related Changes in the Orbicularis Oris Muscle and Their Implications on Aesthetic Lip Rejuvenation"],"prefix":"10.1097","volume":"52","author":[{"given":"Kyu-Ho","family":"Yi","sequence":"first","affiliation":[{"name":"Division in Anatomy and Developmental Biology, Department of Oral Biology, Human Identification Research Institute, BK21 FOUR Project, Yonsei University College of Dentistry, Seoul, South Korea;"},{"name":"You and I Clinic, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-hyun","family":"Kim","sequence":"additional","affiliation":[{"name":"You and I Clinic, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song E.","family":"Yoon","sequence":"additional","affiliation":[{"name":"BRANDNEW Aesthetic Surgery Clinic, Seoul, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac K.J.","family":"Wong","sequence":"additional","affiliation":[{"name":"The Artisan Clinic, Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovian","family":"Wan","sequence":"additional","affiliation":[{"name":"Medical Research Inc., Wonju, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Bin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oral Anatomy, Institute of Biomaterial Implant, College of Dentistry, Wonkwang University, Iksan, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"R1-20260729","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/asj\/sjaa339","article-title":"The facial aging process from the \u201cInside Out\u201d","volume":"41","author":"Swift","year":"2021","journal-title":"Aesthet Surg J"},{"key":"R2-20260729","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1055\/s-0041-1725104","article-title":"Anatomy and aging of the perioral region","volume":"37","author":"Morera","year":"2021","journal-title":"Facial Plast Surg"},{"key":"R3-20260729","doi-asserted-by":"crossref","first-page":"23","DOI":"10.36849\/JDD.6304","article-title":"Lip augmentation with hyaluronic acid fillers: a review of considerations and techniques","volume":"22","author":"Cooper","year":"2023","journal-title":"J Drugs 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integrated approach to perioral rejuvenation","volume":"39","author":"Penna","year":"2015","journal-title":"Aesthet Plast Surg"},{"issue":"2","key":"R9-20260729","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1097\/SCS.0000000000011077","article-title":"Upper lip single-point technique for lip reshaping: a safe, minimalistic approach in over 500 patients-a retrospective study","volume":"36","author":"Vitale","year":"2025","journal-title":"J Craniofac Surg"},{"key":"R10-20260729","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0039-1681070","article-title":"Corner of the mouth-reversing the earliest sign of aging","volume":"35","author":"Ho","year":"2019","journal-title":"Facial Plast Surg"},{"key":"R11-20260729","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1097\/SAP.0000000000000931","article-title":"Aging changes of the Male Lips-A lesser evil than in females?","volume":"78","author":"Penna","year":"2017","journal-title":"Ann Plast Surg"},{"key":"R12-20260729","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/ca.23379","article-title":"Positional relationship of superior and inferior labial artery by ultrasonography image analysis for safe lip augmentation procedures","volume":"33","author":"Lee","year":"2020","journal-title":"Clin Anat"},{"key":"R13-20260729","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/PRS.0b013e31829accb6","article-title":"Analysis and classification of the upper lip aesthetic unit","volume":"132","author":"Raphael","year":"2013","journal-title":"Plast Reconstr Surg"}],"container-title":["Dermatologic 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