{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:55:14Z","timestamp":1790888114829,"version":"4.1.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","license":[{"start":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:00:00Z","timestamp":1790899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"This research was funded by Galderma."}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Dermatol Surg","DS"],"abstract":"\n BACKGROUND<\/jats:title>\n \n HA\n SHA<\/jats:sub>\n is a novel, NASHA HD Technology, hyaluronic acid (HA) injectable, optimized for lower-face shaping.\n <\/jats:p>\n <\/jats:sec>\n \n OBJECTIVES<\/jats:title>\n \n This multicenter study evaluated effectiveness and safety of HA\n SHA<\/jats:sub>\n in improving jawline definition for up to 2 years.\n <\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n \n Subjects with moderate-to-very-severe volume deficiency on the Galderma Jawline Scale (GJS) were randomized 3:1 to HA\n SHA<\/jats:sub>\n injections (via needle or cannula) or no-treatment control. At Month 12, HA\n SHA<\/jats:sub>\n -treated subjects were offered optional re-treatment and controls were offered first treatment with HA\n SHA<\/jats:sub>\n .\n <\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n At Month 3, the HA\n SHA<\/jats:sub>\n group (\n N<\/jats:italic>\n = 168) had a statistically significant (\n p<\/jats:italic>\n < .001) higher \u22651-grade blinded evaluator-assessed GJS responder rate than the no-treatment group (\n N<\/jats:italic>\n = 68) (85.1% vs 14.3%, primary endpoint), which remained high in the HA\n SHA<\/jats:sub>\n group at Months 12 (67.1%) and 24 (69.0% without re-treatment; 81.3% with Month-12 re-treatment). Treating-investigator-assessed Global Aesthetic Improvement Scale improvement rates were \u226584% at Months 3 to 24. Most HA\n SHA<\/jats:sub>\n -treated subjects reported improved overall satisfaction with their appearance (\u226570%) and natural-looking results (\u226582%) through Month 24. Treatment-related adverse events, all mild or moderate, occurred in 14.5% of subjects after initial treatment.\n <\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n \n HA\n SHA<\/jats:sub>\n was superior to no-treatment for improving jawline definition, with improvement lasting throughout 24 months. Subject satisfaction was high. Treatment was well tolerated.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/dss.0000000000005378","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:00:54Z","timestamp":1790884854000},"update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness and Safety of a High G\u2032 Hyaluronic Acid Injectable for Jawline Definition: A Randomized Controlled Clinical Investigation"],"prefix":"10.1097","author":[{"given":"Sachin M.","family":"Shridharani","sequence":"first","affiliation":[{"name":"Luxurgery, New York, New York;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glynis","family":"Ablon","sequence":"additional","affiliation":[{"name":"Ablon Skin Institute and Research Center, Manhattan Beach, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Hevia","sequence":"additional","affiliation":[{"name":"Hevia Cosmetic Dermatology, Coral Gables, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Weiss","sequence":"additional","affiliation":[{"name":"Laser Skin and Vein, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Joseph","sequence":"additional","affiliation":[{"name":"Amalfi Bio, Jacksonville, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose R.","family":"Montes","sequence":"additional","affiliation":[{"name":"Jose Raul Montes Eyes and Facial Rejuvenation LLC, San Juan, Puerto Rico;"},{"name":"Ophthalmology Department, University of Puerto Rico, San Juan, Puerto Rico;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Coleman","sequence":"additional","affiliation":[{"name":"Etre Cosmetic Dermatology and Laser Center, New Orleans, Louisiana;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Donath","sequence":"additional","affiliation":[{"name":"Elite Aesthetic Research, Cincinnati, Ohio;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalyn","family":"George","sequence":"additional","affiliation":[{"name":"Wilmington Dermatology Center, Wilmington, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Biesman","sequence":"additional","affiliation":[{"name":"Brian S Biesman, MD (Private Practice), Nashville, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod","family":"Rohrich","sequence":"additional","affiliation":[{"name":"Rod J. Rohrich, MD (Private Practice), Dallas, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel L.","family":"Cohen","sequence":"additional","affiliation":[{"name":"AboutSkin Dermatology and DermSurgery, Greenwood Village, Colorado;"},{"name":"Department of Dermatology, University of California, Irvine, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Somenek","sequence":"additional","affiliation":[{"name":"Somenek + Pittman MD, Washington, District of Columbia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Baumann","sequence":"additional","affiliation":[{"name":"Baumann Cosmetic and Research Institute, Inc., Miami, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E.","family":"Cox","sequence":"additional","affiliation":[{"name":"Aesthetic Solutions, Pennsylvania, Chapel Hill, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Galderma, Uppsala, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Rugheimer","sequence":"additional","affiliation":[{"name":"Galderma, Uppsala, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Galderma Laboratories, Fort Worth, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torun","family":"Brom\u00e9e","sequence":"additional","affiliation":[{"name":"Galderma, Uppsala, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,10,2]]},"reference":[{"key":"R1-20261001","first-page":"399","article-title":"Anatomy of the facial fat compartments and their relevance in aesthetic 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