{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:10:37Z","timestamp":1724649037098},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T00:00:00Z","timestamp":1710460800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>Contemporary guidelines pertaining to the evaluation of bleeding risk recommend conducting a comprehensive examination of both personal and family histories concerning haemorrhagic diatheses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVES<\/jats:title>\n            <jats:p>We employed the standardised HEMSTOP (Hematoma, hEmorrhage, Menorrhagia, Surgery, Tooth extraction, Obstetrics, Parents) questionnaire in pregnant women to evaluate its efficacy in detecting a haemostatic disorder and predicting the risk of haemorrhage associated with delivery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN<\/jats:title>\n            <jats:p>A single-centre retrospective observational cohort study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTING<\/jats:title>\n            <jats:p>Brugmann Hospital, a tertiary university institution.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS<\/jats:title>\n            <jats:p>All full-term parturients who underwent vaginal or caesarean delivery in our hospital between January 2020 and December 2021 were included in the study. A total of 3588 patients were enrolled.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n            <jats:p>The primary aim of this study was to assess the sensitivity and specificity of the HEMSTOP questionnaire in identifying individuals with an abnormal primary haemostatic profile. The secondary objective was to evaluate the sensitivity and specificity of the HEMSTOP questionnaire in predicting postpartum haemorrhage (PPH; defined as blood loss &gt;1000\u200aml). Additionally, positive-predictive values and negative-predictive values (NPVs) were calculated.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>The specificity and sensitivity of the HEMSTOP questionnaire to predict an abnormal standard coagulation test in pregnant women are respectively 96% [95% confidence interval (CI), 0.95 to 0.97] and 39% (95% CI, 0.20 to 0.61). Its NPV is 100%. The specificity and sensitivity of the HEMSTOP questionnaire to predict postpartum bleeding risk are respectively 96% (95% CI, 0.95 to 0.97) and 8% (95% CI, 0.06 to 0.11).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>In the conditions of our study, the HEMSTOP questionnaire enables the prediction of a primary haemostatic anomaly with a specificity and sensitivity comparable to routine haemostatic assessments. These findings concur with the recommendation against the routine prescription of laboratory tests for patients lacking a history of bleeding diathesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>TRIAL REGISTRATION<\/jats:title>\n            <jats:p>Clinical Trial NCT 05191251.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ea9.0000000000000050","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T10:00:09Z","timestamp":1710756009000},"page":"e0050","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of haemostasis in pregnant women"],"prefix":"10.1097","volume":"3","author":[{"given":"Tamara","family":"Zec","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Schmartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pomeline","family":"Temmerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Fils","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brigitte","family":"Ickx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanny","family":"Bonhomme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Van Der Linden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,4]]},"reference":[{"key":"R1-20240826","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/EJA.0b013e32835f66cd","article-title":"Testing for the FA and ICC on E of RP. Preinterventional haemostatic assessment: Guidelines from the French Society of Anaesthesia and Intensive Care","volume":"30","author":"Bonhomme","year":"2013","journal-title":"Eur J Anaesthesiol"},{"key":"R2-20240826","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1007\/s12630-016-0688-9","article-title":"Preoperative hemostatic assessment: a new and simple bleeding questionnaire","volume":"63","author":"Bonhomme","year":"2016","journal-title":"Can J Anesth Can Anesth"},{"key":"R4-20240826","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.anclin.2020.08.010","article-title":"Obstetric hemorrhage","volume":"38","author":"Hawkins","year":"2020","journal-title":"Anesthesiol Clin"},{"key":"R5-20240826","doi-asserted-by":"crossref","first-page":"e168","DOI":"10.1097\/AOG.0000000000002351","article-title":"Committee on Practice Bulletins-Obstetrics Practice Bulletin No. 183: Postpartum Hemorrhage","volume":"130","year":"2017","journal-title":"Obstet 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