{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T05:10:37Z","timestamp":1724649037251},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"\n BACKGROUND<\/jats:title>\n The NARCOguide algorithm calculates an EEG-derived index to monitor the hypnotic component of anaesthesia.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE<\/jats:title>\n This study evaluates the accuracy of the index calculated by NARCOguide against the Narcotrend index as a reference. Secondly, the automatic detection of burst-suppression patterns as represented by the burst suppression ratio was compared.<\/jats:p>\n <\/jats:sec>\n \n DESIGN<\/jats:title>\n Comparative study to assess the agreement between two medical devices.<\/jats:p>\n <\/jats:sec>\n \n SETTING<\/jats:title>\n At two study centres, patient data were collected from a total of 40 adults receiving general anaesthesia or sedation with propofol.<\/jats:p>\n <\/jats:sec>\n \n INTERVENTIONS<\/jats:title>\n Patients underwent either general anaesthesia for oral surgery with propofol\/remifentanil\/rocuronium (study centre 1) or light general anaesthesia\/deep sedation with propofol alone for laryngoscopic upper airway exploration (study centre 2).<\/jats:p>\n <\/jats:sec>\n \n MAIN OUTCOME MEASURES<\/jats:title>\n In a posthoc analysis, the NARCOguide index was compared with the Narcotrend index. Comparison was made after averaging over 1\u200amin at defined clinical markers using classic linear least squares regression and Bland\u2013Altman plots. Precision and recall for the detection of burst suppression were determined using human scoring as a reference.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n Data analysis showed good agreement [Bland\u2013Altman mean difference (MD) = \u22122.3; limits of agreement = \u221227.1, to +22.4; n<\/jats:italic> = 1209] and high correlation (r<\/jats:italic>\n 2<\/jats:sup> = 0.76) between the depth of anaesthesia index calculated by NARCOguide and Narcotrend. The precision and recall of NARCOguide and Narcotrend for the detection of burst suppression were in a similar range. Over the entire dataset, the NARCOguide algorithm showed higher precision and recall than the Narcotrend algorithm (56% vs. 36% and 68% vs. 58%, respectively).<\/jats:p>\n <\/jats:sec>\n \n CONCLUSION<\/jats:title>\n The NARCOguide index can be used to monitor the hypnotic component of anaesthesia in patients undergoing general anaesthesia or sedation with propofol, with a performance similar to that of the Narcotrend index.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION<\/jats:title>\n Trial registration number: 18020, regulatory authority: Ethikkommission der bayerischen Landes\u00e4rztekammer, chairman: Dr med. Gerald Quitterer, applicant: Dr Gert K\u00fcchler, date of approval: 12. Jun 2018, completion of data collection: 12 December 2018, study completion: 31 March 2022.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/ea9.0000000000000057","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T14:00:07Z","timestamp":1721311207000},"page":"e0057","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["The NARCOguide index \u2013 a novel parameter for monitoring depth of hypnosis during anaesthesia\/sedation with propofol"],"prefix":"10.1097","volume":"3","author":[{"given":"Florian","family":"Hetzer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Horack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gert","family":"K\u00fcchler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Broscheit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,8]]},"reference":[{"key":"R1-20240826","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1213\/ANE.0000000000002331","article-title":"The technology of processed electroencephalogram monitoring devices for assessment of depth of anesthesia","volume":"126","author":"Fahy","year":"2018","journal-title":"Anesth Analg"},{"key":"R2-20240826","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00421-011-1983-3","article-title":"Continuous blood pressure measurement by using the pulse transit time: comparison to a cuff-based method","volume":"112","author":"Gesche","year":"2012","journal-title":"Eur J Appl Physiol"},{"key":"R3-20240826","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1213\/ANE.0000000000001340","article-title":"Blood pressure monitoring for the anesthesiologist: a practical review","volume":"122","author":"Bartels","year":"2016","journal-title":"Anesth Analg"},{"key":"R4-20240826","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1515\/bmte.2002.47.1-2.9","article-title":"Automatic classification algorithms of the EEG monitor Narcotrend for routinely recorded EEG data from general anaesthesia: a validation study","volume":"47","author":"Schultz","year":"2002","journal-title":"Biomed Tech (Berl)"},{"key":"R5-20240826","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two methods of clinical measurement","volume":"1","author":"Bland","year":"1986","journal-title":"Lancet"},{"key":"R6-20240826","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/(SICI)1097-4571(199401)45:1<12::AID-ASI2>3.0.CO;2-L","article-title":"The relationship between recall and precision","volume":"45","author":"Buckland","year":"1994","journal-title":"J Am Soc Inform Sci"},{"key":"R7-20240826","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/bja\/ael171","article-title":"Correlation and agreement between bispectral index and state entropy of the electroencephalogram during propofol anaesthesia","volume":"97","author":"Bonhomme","year":"2006","journal-title":"Br J Anaesth"},{"key":"R8-20240826","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1213\/01.ane.0000255152.96354.17","article-title":"Performance of the cerebral state index during increasing levels of propofol anesthesia: a comparison with the bispectral index","volume":"104","author":"Cort\u00ednez","year":"2007","journal-title":"Anesth Analg"},{"key":"R10-20240826","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s00101-003-0603-y","article-title":"Der Narcotrend\u00ae-Monitor","volume":"52","author":"Schultz","year":"2003","journal-title":"Der Anaesthesist"}],"container-title":["European Journal of Anaesthesiology Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/EA9.0000000000000057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,26]],"date-time":"2024-08-26T04:01:21Z","timestamp":1724644881000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/EA9.0000000000000057"}},"subtitle":["A comparison study with the Narcotrend index"],"short-title":[],"issued":{"date-parts":[[2024,7,18]]},"references-count":9,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/ea9.0000000000000057","relation":{},"ISSN":["2767-7206"],"issn-type":[{"type":"electronic","value":"2767-7206"}],"subject":[],"published":{"date-parts":[[2024,7,18]]}}}