{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T04:02:45Z","timestamp":1750132965373,"version":"3.41.0"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T00:00:00Z","timestamp":1750032000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In 2024, an extreme increase in the number of parvovirus B19 (B19V) infections occurred worldwide, including in the pregnant population, resulting in severe foetal morbidity and mortality. We describe the case of a 37-year-old patient (G2\/P1) who was 26\u200aweeks 0\u200adays pregnant at admission and who presented with foetal hydrops and mirror syndrome due to B19V infection and sudden onset of acute perimyocarditis in the mother, possibly triggered by the foetal situation and severe anaemia.<\/jats:p>\n            <jats:p>Foetal hydrops is a life-threatening manifestation of foetal infection with B19V. Independent of whether it is immune or nonimmune, hydrops fetal is occurs in 1\u200a:\u200a1500 to 4000 pregnancies. In 6.1% of foetal hydrops cases, the hydrops mirrors the symptoms between the mother and the child. Mirror syndrome was defined as foetal hydrops and\/or placentomegaly associated with the maternal development of pronounced oedema with or without preeclampsia symptoms. Due to the increase in infections and the potentially foetal consequences for the unborn child, the possible therapy, which requires well coordinated multidisciplinary cooperation, is relevant for anaesthesiologists as demonstrated in the following case.<\/jats:p>\n            <jats:p>The patient underwent two foetal transfusions and one foetal ascites puncture; consequently, she required anaesthesiological care on multiple occasions. We emphasise the importance of ensuring that patients with this condition are closely monitored, not only by the obstetrician but also by the anaesthesiologist, so that the clinical deterioration of the mother and\/or the child can be quickly recognised and treated appropriately.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ea9.0000000000000078","type":"journal-article","created":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:00:12Z","timestamp":1750075212000},"page":"e0078","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Infection with parvovirus B19 and the maternal, mirror syndrome"],"prefix":"10.1097","volume":"4","author":[{"given":"Patrizia","family":"R\u00f6lli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Vifian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"de Marchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Raio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1860-2718","authenticated-orcid":false,"given":"Christian","family":"Vetter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"R3-20250616","doi-asserted-by":"crossref","first-page":"e475","DOI":"10.1016\/S1473-3099(24)00373-6","article-title":"Extreme upsurge of parvovirus B19 resulting in severe fetal morbidity and mortality","volume":"24","author":"Russcher","year":"2024","journal-title":"Lancet Infect Dis"},{"key":"R4-20250616","doi-asserted-by":"crossref","first-page":"139","DOI":"10.3390\/jpm14020139","article-title":"Parvovirus B19 infection and pregnancy: review of the current knowledge","volume":"14","author":"Dittmer","year":"2024","journal-title":"J Pers Med"},{"key":"R5-20250616","first-page":"e21726","article-title":"Parvovirus B19-associated myocarditis: a literature review of pediatric cases","volume":"14","author":"Keramari","year":"2022","journal-title":"Cureus"},{"key":"R6-20250616","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000305096","article-title":"Mirror syndrome: a systematic review of fetal associated conditions, maternal presentation and perinatal outcome","volume":"27","author":"Braun","year":"2010","journal-title":"Fetal Diagn Ther"},{"key":"R7-20250616","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/j.1365-2230.2008.02713.x","article-title":"Acute heart failure associated with human parvovirus B19 infection","volume":"33","author":"Seishima","year":"2008","journal-title":"Clin Exp Dermatol"},{"key":"R8-20250616","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/0140-6736(93)90973-K","article-title":"Heart failure after parvovirus B19 infection","volume":"341","author":"Malm","year":"1993","journal-title":"Lancet"},{"key":"R9-20250616","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1056\/NEJM200001063420102","article-title":"Noninvasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses","volume":"342","author":"Mari","year":"2000","journal-title":"N Engl J Med"},{"key":"R10-20250616","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1414838","article-title":"Predictive value of the sFlt-1:PlGF ratio in women with suspected preeclampsia","volume":"374","author":"Zeisler","year":"2016","journal-title":"N Engl J Med"},{"key":"R11-20250616","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.CIR.0000155615.68924.B3","article-title":"High prevalence of cardiac parvovirus B19 infection in patients with isolated left ventricular diastolic dysfunction","volume":"111","author":"Tsch\u00f6pe","year":"2005","journal-title":"Circulation"},{"key":"R12-20250616","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1002\/pd.6589","article-title":"Maternal \u201cmirror\u201d syndrome: evaluating the benefits of fetal therapy","volume":"44","author":"Sichitiu","year":"2024","journal-title":"Prenat Diagn"},{"key":"R13-20250616","first-page":"2630","article-title":"Clinical characteristics of mirror syndrome: a comparison of 10 cases of mirror syndrome with nonmirror syndrome fetal hydrops cases","volume":"29","author":"Hirata","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"R14-20250616","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/01443615.2020.1718621","article-title":"Clinical characteristics of mirror syndrome: a retrospective study of 16 cases","volume":"41","author":"Chen","year":"2021","journal-title":"J Obstet Gynaecol"},{"key":"R15-20250616","doi-asserted-by":"crossref","first-page":"322","DOI":"10.3109\/10641950903323244","article-title":"Preeclampsia due to fetal nonimmune hydrops: mirror syndrome and review of literature","volume":"30","author":"Gedikbasi","year":"2011","journal-title":"Hypertens Pregnancy"},{"key":"R16-20250616","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1080\/14767058.2018.1500550","article-title":"Mirroring preeclampsia: the molecular basis of Ballantyne syndrome","volume":"33","author":"Hobson","year":"2020","journal-title":"J Matern Fetal Neonatal Med"},{"key":"R17-20250616","doi-asserted-by":"crossref","first-page":"101067","DOI":"10.1016\/j.ajogmf.2023.101067","article-title":"Mirror syndrome: a systematic literature review","volume":"5","author":"Biswas","year":"2023","journal-title":"Am J Obstet Gynecol MFM"}],"container-title":["European Journal of Anaesthesiology Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/EA9.0000000000000078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T12:00:16Z","timestamp":1750075216000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/EA9.0000000000000078"}},"subtitle":["A case report"],"short-title":[],"issued":{"date-parts":[[2025,6,16]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/ea9.0000000000000078","relation":{},"ISSN":["2767-7206"],"issn-type":[{"value":"2767-7206","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,16]]},"assertion":[{"value":"2025-02-05","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-13","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}