{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:21:44Z","timestamp":1792671704263,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Limited research suggests ambient air pollution impairs fecundity but groups most susceptible have not been identified. We studied whether long-term ambient air pollution exposure before an in vitro fertilization (IVF) cycle was associated with successful livebirth, and whether associations were modified by underlying infertility diagnosis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Data on women initiating their first autologous IVF cycle in 2012\u20132013 were obtained from four US clinics. Outcomes included pregnancy, pregnancy loss, and livebirth. Annual average exposure to fine particulate matter (PM<jats:sub>2.5<\/jats:sub>), PM<jats:sub>10<\/jats:sub>, and nitrogen dioxide (NO<jats:sub>2<\/jats:sub>) before IVF start were estimated at residential address using a validated national spatial model incorporating land-use regression and universal kriging. We also assessed residential distance to major roadway. We calculated risk ratios (RR) using modified Poisson regression and evaluated effect modification (EM) by infertility diagnosis on additive and multiplicative scales.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Among 7,463 eligible participants, 36% had a livebirth. There was a nonsignificant indication of an association between PM<jats:sub>2.5<\/jats:sub> or NO<jats:sub>2<\/jats:sub> and decreased livebirth and increased pregnancy loss. Near-roadway residence was associated with decreased livebirth (RR = 0.96, 95% CI = 0.82, 0.99). There was evidence for EM between high exposure to air pollutants and a diagnosis of diminished ovarian reserve (DOR) or male infertility and decreased livebirth.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Despite suggestive but uncertain findings for the overall effect of air pollution on fecundity, we found a suggestive indication that there may be synergistic effects of air pollution and DOR or male infertility diagnosis on livebirth. This suggests two possible targets for future research and intervention.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ee9.0000000000000036","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T06:05:43Z","timestamp":1550124343000},"page":"e036","source":"Crossref","is-referenced-by-count":38,"title":["Ambient Air Pollution Exposure and Fecundability in Women Undergoing In Vitro Fertilization"],"prefix":"10.1097","volume":"3","author":[{"given":"Sabah M.","family":"Quraishi","sequence":"first","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul C.","family":"Lin","sequence":"additional","affiliation":[{"name":"Seattle Reproductive Medicine, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin S.","family":"Richter","sequence":"additional","affiliation":[{"name":"Shady Grove Fertility, Rockville, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary D.","family":"Hinckley","sequence":"additional","affiliation":[{"name":"Reproductive Science Center, San Ramon, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Yee","sequence":"additional","affiliation":[{"name":"Reproductive Partners Medical Group, Redondo Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genevieve","family":"Neal-Perry","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Departments of Biostatistics and Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel D.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Departments of Environmental and Occupational Health Sciences, Epidemiology, and Medicine, University of Washington, Seattle, Washington."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjum","family":"Hajat","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R3-20230908","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1161\/CIR.0b013e3181dbece1","article-title":"Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart 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