{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:25:08Z","timestamp":1790393108886,"version":"4.1.0"},"reference-count":75,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2019,12,1]],"date-time":"2019-12-01T00:00:00Z","timestamp":1575158400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:p>We reviewed epidemiologic studies of the association between exposure to air pollution from industries and asthma-related outcomes in childhood. We searched bibliographic databases and reference lists of relevant articles to identify studies examining the association between children\u2019s exposure to air pollution from industrial point-sources and asthma-related outcomes, including asthma, asthma-like symptoms, wheezing, and bronchiolitis. We extracted key characteristics of each study and when appropriate we performed a random-effects meta-analysis of results and quantified heterogeneity (<jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup>). Thirty-six studies were included in this review. Meta-analysis was generally not possible and limited to a few studies because of substantial variation across design characteristics and methodologies. In case-crossover studies using administrative health data, pooled odds ratio (OR) of hospitalization for asthma and bronchiolitis in children &lt;5 years were 1.02 [95% confidence intervals (CI): 0.96, 1.08; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup> = 56%] and 1.01 (95% CI: 0.97, 1.05; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup> = 64%) per 10 ppb increase in the daily mean and hourly maximum concentration of sulfur dioxide (SO<jats:sub>2<\/jats:sub>), respectively. For PM<jats:sub>2.5<\/jats:sub>, pooled ORs were 1.02 (95% CI: 0.93, 1.10; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup> = 56%) and 1.01 (95% CI: 0.98, 1.03 <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup> = 33%) per 10 \u03bcg\/m<jats:sup>3<\/jats:sup> increment in the daily mean and hourly maximum concentration. In cross-sectional studies using questionnaires, pooled ORs for the prevalence of asthma and wheezing in relation to residential proximity to industry were 1.98 (95% CI: 0.87, 3.09; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup> =71%) and 1.33 (95% CI: 0.86, 1.79; <jats:italic toggle=\"yes\">I<\/jats:italic>\n                           <jats:sup>2<\/jats:sup>= 65%), respectively. In conclusion, this review showed substantial heterogeneity across study designs and methods. Meta-analysis results suggested no evidence of an association for short-term asthma-related effects and an indication for long-term effects, but heterogeneity between results and limitations in terms of design and exposure assessment preclude drawing definite conclusions. Further well-conducted studies making use of a longitudinal design and of refined exposure assessment methods are needed to improve risk estimates.<\/jats:p>","DOI":"10.1097\/ee9.0000000000000077","type":"journal-article","created":{"date-parts":[[2019,12,11]],"date-time":"2019-12-11T09:07:59Z","timestamp":1576055279000},"page":"e077","source":"Crossref","is-referenced-by-count":20,"title":["Review of the effect of air pollution exposure from industrial point sources on asthma-related effects in childhood"],"prefix":"10.1097","volume":"3","author":[{"given":"St\u00e9phane","family":"Buteau","sequence":"first","affiliation":[{"name":"Institut national de sante publique du Quebec (INSPQ), Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, School of Public Health, University of Montreal, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Remi","family":"Labelle","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, School of Public Health, University of Montreal, Montreal, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Smargiassi","sequence":"additional","affiliation":[{"name":"Institut national de sante publique du Quebec (INSPQ), Montreal, Quebec, Canada"},{"name":"Department of Environmental and Occupational Health, School of Public Health, University of Montreal, Montreal, Canada"},{"name":"University of Montreal, Public Health Research Institute, Montreal, Canada."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,12]]},"reference":[{"key":"R3-20230908","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/15287390701598234","article-title":"Children\u2019s response to air pollutants.","volume":"71","author":"Bateson","year":"2008","journal-title":"J Toxicol Environ Health A"},{"key":"R4-20230908","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00003727-200201000-00004","article-title":"Kids need clean air: air pollution and children\u2019s health.","volume":"24","author":"Dixon","year":"2002","journal-title":"Fam Community Health"},{"issue":"suppl 3","key":"R5-20230908","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1289\/ehp.99107s3403","article-title":"A theoretical basis for investigating ambient air pollution and children\u2019s respiratory health.","volume":"107","author":"Gilliland","year":"1999","journal-title":"Environ Health Perspect"},{"issue":"4 suppl","key":"R6-20230908","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1542\/peds.113.S3.1037","article-title":"Air pollution and children\u2019s health.","volume":"113","author":"Schwartz","year":"2004","journal-title":"Pediatrics"},{"key":"R7-20230908","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/EDE.0000000000000016","article-title":"Asthma morbidity and ambient air pollution: effect modification by residential traffic-related air pollution.","volume":"25","author":"Delfino","year":"2014","journal-title":"Epidemiology"},{"key":"R8-20230908","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/BF03404060","article-title":"Air pollution and emergency department visits for asthma in Windsor, Canada.","volume":"103","author":"Lavigne","year":"2012","journal-title":"Can J Public Health"},{"key":"R9-20230908","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.envres.2011.01.014","article-title":"Acute effects of air pollution on pediatric asthma exacerbation: evidence of association and effect modification.","volume":"111","author":"Samoli","year":"2011","journal-title":"Environ Res"},{"key":"R10-20230908","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1164\/rccm.200908-1201OC","article-title":"Short-term associations between ambient air pollutants and pediatric asthma emergency department visits.","volume":"182","author":"Strickland","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"R11-20230908","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1164\/rccm.201512-2434OC","article-title":"Fine particulate matter and emergency room visits for respiratory illness. 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