{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T22:43:41Z","timestamp":1767912221711,"version":"3.49.0"},"reference-count":41,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","license":[{"start":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T00:00:00Z","timestamp":1716768000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:sec>\n            <jats:title>BACKGROUND<\/jats:title>\n            <jats:p>For nearly 20\u200ayears, in international guidelines, mild therapeutic hypothermia (MTH) was an important component of postresuscitation care. However, recent randomised controlled trials have questioned its benefits. At present, international guidelines only recommend actively preventing fever, but there are ongoing discussions about whether the majority of cardiac arrest patients could benefit from MTH treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>OBJECTIVE<\/jats:title>\n            <jats:p>The aim of this study was to compare the outcome of adult patients treated with and without MTH after cardiac arrest.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>DESIGN<\/jats:title>\n            <jats:p>Observational cohort study.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>SETTING<\/jats:title>\n            <jats:p>German Resuscitation Registry covering more than 31 million inhabitants of Germany and Austria.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>PATIENTS<\/jats:title>\n            <jats:p>All adult patients between 2006 and 2022 with out-of-hospital or in-hospital cardiac arrest and comatose on admission.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>MAIN OUTCOME MEASURES<\/jats:title>\n            <jats:p>Primary endpoint: hospital discharge with good neurological outcome [cerebral performance categories (CPC) 1 or 2]. Secondary endpoint: hospital discharge. We used a multivariate binary logistic regression analysis to identify the effects on outcome of all known influencing variables.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>RESULTS<\/jats:title>\n            <jats:p>We analysed 33\u200a933 patients (10\u200a034 treated with MTH, 23\u200a899 without MTH). The multivariate regression model revealed that MTH was an independent predictor of CPC 1\/2 survival and of hospital discharge with odds ratio (95% confidence intervals) of 1.60 (1.49 to 1.72), <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.001 and 1.89 (1.76 to 2.02), <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a&lt;\u200a0.001, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>CONCLUSION<\/jats:title>\n            <jats:p>Our data indicate the existence of a positive association between MTH and a favourable neurological outcome after cardiac arrest. It therefore seems premature to refrain from giving MTH treatment for the entire spectrum of patients after cardiac arrest. Further prospective studies are needed.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/eja.0000000000002016","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T09:00:06Z","timestamp":1716886806000},"page":"779-786","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":5,"title":["Mild therapeutic hypothermia after cardiac arrest \u2013 effect on survival with good neurological outcome outside of randomised controlled trials"],"prefix":"10.1097","volume":"41","author":[{"given":"J\u00fcrgen","family":"Knapp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Heilman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Bernhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"R1-20250801","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.resuscitation.2021.02.012","article-title":"European Resuscitation Council and European Society of Intensive Care Medicine Guidelines 2021: postresuscitation care","volume":"161","author":"Nolan","year":"2021","journal-title":"Resuscitation"},{"key":"R2-20250801","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1056\/NEJMoa2100591","article-title":"Hypothermia versus normothermia after out-of-hospital cardiac arrest","volume":"384","author":"Dankiewicz","year":"2021","journal-title":"N Engl J Med"},{"key":"R3-20250801","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.resuscitation.2022.01.009","article-title":"ERC-ESICM guidelines on temperature control after cardiac arrest in adults","volume":"172","author":"Nolan","year":"2022","journal-title":"Resuscitation"},{"key":"R4-20250801","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/EJA.0000000000001663","article-title":"The effectiveness of targeted temperature management following cardiac arrest may depend on bystander cardiopulmonary resuscitation rates","volume":"39","author":"Bottiger","year":"2022","journal-title":"Eur J Anaesthesiol"},{"key":"R5-20250801","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/MEJ.0000000000000886","article-title":"Targeted temperature management after resuscitation from cardiac arrest: the importance of emergency physicians","volume":"28","author":"Behringer","year":"2021","journal-title":"Eur J Emerg Med"},{"key":"R6-20250801","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/MEJ.0000000000001106","article-title":"Temperature control after successful resuscitation from cardiac arrest in adults: a joint statement from the European Society for Emergency Medicine (EUSEM) and the European Society of Anaesthesiology and Intensive Care (ESAIC)","volume":"31","author":"Behringer","year":"2023","journal-title":"Eur J Emerg Med"},{"key":"R7-20250801","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.resuscitation.2019.12.042","article-title":"Survival after out-of-hospital cardiac arrest in Europe - results of the EuReCa TWO study","volume":"148","author":"Grasner","year":"2020","journal-title":"Resuscitation"},{"key":"R8-20250801","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.resuscitation.2020.02.044","article-title":"Out-of-hospital cardiac arrest across the world: first report from the International Liaison Committee on Resuscitation (ILCOR)","volume":"152","author":"Kiguchi","year":"2020","journal-title":"Resuscitation"},{"key":"R9-20250801","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.resuscitation.2021.02.002","article-title":"Targeted temperature management after cardiac arrest. 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