{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:34:57Z","timestamp":1793144097708,"version":"4.5.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd-sa\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Endosc Ultrasound"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title>Background and Objectives<\/jats:title>\n            <jats:p>Several types of needles are available for EUS\u2013guided tissue sampling of pancreatic lesions. Whereas fine-needle aspiration (FNA) needles typically provide cytological samples, fine-needle biopsy (FNB) needles are designed to obtain microcores with preserved tissue architecture. The aim of this study was to compare tissue amount and diagnostic yield between a modified Franseen-type FNB needle (TopGain; Medi-Globe GmbH, Grassau, Germany) and a standard FNA needle.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We performed a prospective, multicenter randomized controlled study between June 2020 and September 2021, including patients with a solid pancreatic lesion referred for EUS-guided tissue sampling at 3 centers in Denmark. The patients were randomized 1:1 to either FNA needle or the novel FNB needle. Primary outcomes included the number of obtained tissue microcores and total and diagnostic tissue area.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Sixty-four patients were included. The median number of tissue microcores procured per pass was significantly higher in the FNB group compared with FNA (3 <jats:italic toggle=\"yes\">vs<\/jats:italic>. 2, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Similarly, the mean total tissue area (2.74 <jats:italic toggle=\"yes\">vs<\/jats:italic>. 0.44 mm<jats:sup>2<\/jats:sup>, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) and mean diagnostic tissue area (1.74 <jats:italic toggle=\"yes\">vs<\/jats:italic>. 0.28 mm<jats:sup>2<\/jats:sup>, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001) were more than 6-fold larger in the FNB samples compared with FNA. The median number of passes needed for a diagnostic sample was 1 for the FNB needle and 2 for FNA needle (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.12). The novel FNB needle provided a higher percentage of samples of excellent quality (<jats:italic toggle=\"yes\">P<\/jats:italic> = 0.002).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>The novel Franseen-type FNB needle seems to be significantly superior to a conventional FNA needle. The results of this study underline excellent performance of crown-cut needles.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/eus.0000000000000007","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T11:12:05Z","timestamp":1698664325000},"page":"319-325","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Tissue amount and diagnostic yield of a novel franseen EUS-FNB and a standard EUS-FNA needle\u2014A randomized controlled study in solid pancreatic lesions"],"prefix":"10.1097","volume":"12","author":[{"given":"Bojan","family":"Kovacevic","sequence":"first","affiliation":[{"name":"Gastro Unit, Division of Endoscopy, Copenhagen University Hospital\u2014Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Toxv\u00e6rd","sequence":"additional","affiliation":[{"name":"Department of Pathology, Copenhagen University Hospital\u2014Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"Klausen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Surgery, Odense University Hospital, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Gr\u00fctzmeier","sequence":"additional","affiliation":[{"name":"Gastro Unit, Division of Endoscopy, Copenhagen University Hospital\u2014Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f6nke","family":"Detlefsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G\u00e1sdal","family":"Karstensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Brink","sequence":"additional","affiliation":[{"name":"Gastro Unit, Division of Endoscopy, Copenhagen University Hospital\u2014Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hazem","family":"Hassan","sequence":"additional","affiliation":[{"name":"Gastro Unit, Division of Endoscopy, Copenhagen University Hospital\u2014Herlev and Gentofte, Herlev, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estrid","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vilmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"bib1-20250826","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0016-5107(96)70324-3","article-title":"A new biopsy handle instrument for endoscopic ultrasound\u2013guided fine-needle aspiration biopsy","volume":"43","year":"1996","journal-title":"Gastrointest Endosc"},{"key":"bib2-20250826","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1067\/mge.2003.49","article-title":"Preliminary experience with an EUS-guided Trucut biopsy needle compared with EUS-guided FNA","volume":"57","year":"2003","journal-title":"Gastrointest 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