{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T10:23:16Z","timestamp":1783851796179,"version":"3.55.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:p>COR659 is a new compound, the action of which is exerted <jats:italic toggle=\"yes\">via<\/jats:italic> a dual mechanism: positive allosteric modulation of the GABA<jats:sub>B<\/jats:sub> receptor; antagonism or inverse agonism at the cannabinoid CB<jats:sub>1<\/jats:sub> receptor. Recent lines of experimental evidence have indicated that COR659 potently and effectively reduced operant self-administration of and reinstatement of seeking behaviour for a chocolate-flavoured beverage. The present study was designed to assess whether the ability of COR659 to diminish these addictive-like, food-motivated behaviours extended to a rat model of overeating palatable food. To this end, rats were habituated to feed on a standard rat chow for 3\u2005h\/day; every 4 days, the 3-hour chow-feeding session was followed by a 1-hour feeding session with highly palatable, calorie-rich Danish butter cookies. Even though satiated, rats overconsumed cookies. COR659 (0, 2.5, 5, and 10\u2005mg\/kg, i.p.) was administered before the start of the cookie-feeding session. Treatment with all 3 doses of COR659 produced a substantial decrease in intake of cookies and calories from cookies. These results extend the anorectic profile of COR659 to overconsumption of a highly palatable food and intake of large amounts of unnecessary calories.<\/jats:p>","DOI":"10.1097\/fbp.0000000000000751","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:07:33Z","timestamp":1694779653000},"page":"437-442","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Anorectic effect of COR659 in a rat model of overeating"],"prefix":"10.1097","volume":"34","author":[{"given":"Paola","family":"Maccioni","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Section of Cagliari, National Research Council of Italy, Monserrato (CA)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Mugnaini","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Chemistry, and Pharmacy, University of Siena, Siena 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