{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:09:04Z","timestamp":1786118944645,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,5]]},"DOI":"10.1097\/fbp.0b013e3282feb099","type":"journal-article","created":{"date-parts":[[2008,5,7]],"date-time":"2008-05-07T03:05:52Z","timestamp":1210129552000},"page":"217-224","source":"Crossref","is-referenced-by-count":32,"title":["Glycogen synthase kinase-3\u03b2 heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results"],"prefix":"10.1097","volume":"19","author":[{"given":"Yuly","family":"Bersudsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alona","family":"Shaldubina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitzan","family":"Kozlovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Woodgett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galila","family":"Agam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.H.","family":"Belmaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210202","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/j.1601-183X.2004.00065.x","article-title":"Genetic correlational analysis of glycogen synthase kinase-3 beta and prepulse inhibition in inbred mice","volume":"3","author":"Amar","year":"2004","journal-title":"Genes Brain Behav"},{"key":"R2-6-20210202","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0304-3940(01)01688-3","article-title":"Glycogen synthase kinase-3beta immunoreactivity is reduced in the prefrontal cortex in schizophrenia","volume":"302","author":"Beasley","year":"2001","journal-title":"Neurosci Lett"},{"key":"R3-6-20210202","doi-asserted-by":"crossref","first-page":"5099","DOI":"10.1073\/pnas.0307921101","article-title":"Lithium antagonizes dopamine-dependent behaviors mediated by an AKT\/glycogen synthase kinase 3 signaling cascade","volume":"101","author":"Beaulieu","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R4-6-20210202","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0924-977X(94)90266-6","article-title":"Species differences in susceptibility to Li-pilocarpine seizures","volume":"4","author":"Bersudsky","year":"1994","journal-title":"Eur Neuropsychopharmacol"},{"key":"R6-6-20210202","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/FBP.0b013e32801416ed","article-title":"Lithium's effect in forced-swim test is blood level dependent but not dependent on weight loss","volume":"18","author":"Bersudsky","year":"2007","journal-title":"Behav Pharmacol"},{"key":"R7-6-20210202","doi-asserted-by":"crossref","first-page":"3248","DOI":"10.1523\/JNEUROSCI.19-08-03248.1999","article-title":"Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation","volume":"19","author":"Carter","year":"1999","journal-title":"J Neurosci"},{"key":"R8-6-20210202","first-page":"8.12.1","article-title":"Current protocols in neuroscience","author":"Carter","year":"2001"},{"key":"R9-6-20210202","article-title":"Guide for the care and use of laboratory animals","author":"Council","year":"1996"},{"key":"R10-6-20210202","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1038\/sj.npp.1301431","article-title":"IMPA1 is essential for embryonic development and lithium-like pilocarpine sensitivity","volume":"33","author":"Cryns","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"R11-6-20210202","first-page":"47","article-title":"New approaches to modeling bipolar disorder","volume":"37","author":"Einat","year":"2003","journal-title":"Psychopharmacol Bull"},{"key":"R12-6-20210202","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00401-002-0587-8","article-title":"Glycogen synthase kinase-3 is associated with neuronal and glial hyperphosphorylated tau deposits in Alzheimer's disease, Pick's disease, progressive supranuclear palsy and corticobasal degeneration","volume":"104","author":"Ferrer","year":"2002","journal-title":"Acta Neuropathol (Berl)"},{"key":"R13-6-20210202","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(02)04277-4","article-title":"Alterations in D1\/D2 synergism may account for enhanced stereotypy and reduced climbing in mice lacking dopamine D2L receptor","volume":"967","author":"Fetsko","year":"2003","journal-title":"Brain Res"},{"key":"R14-6-20210202","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/35017574","article-title":"Requirement for glycogen synthase kinase-3beta in cell survival and NF-kappaB activation","volume":"406","author":"Hoeflich","year":"2000","journal-title":"Nature"},{"key":"R15-6-20210202","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/sj.npp.1301399","article-title":"Behavioral effects of chronic fluoxetine in BALB\/cJ mice do not require adult hippocampal neurogenesis or the serotonin 1A receptor","volume":"33","author":"Holick","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"R16-6-20210202","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1126\/science.6301005","article-title":"Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats","volume":"220","author":"Honchar","year":"1983","journal-title":"Science"},{"key":"R17-6-20210202","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0165-6147(03)00206-2","article-title":"Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes","volume":"24","author":"Jope","year":"2003","journal-title":"Trends Pharmacol Sci"},{"key":"R18-6-20210202","doi-asserted-by":"crossref","first-page":"8455","DOI":"10.1073\/pnas.93.16.8455","article-title":"A molecular mechanism for the effect of lithium on development","volume":"93","author":"Klein","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R19-6-20210202","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1176\/appi.ajp.157.5.831","article-title":"Low GSK-3beta immunoreactivity in postmortem frontal cortex of schizophrenic patients","volume":"157","author":"Kozlovsky","year":"2000","journal-title":"Am J Psychiatry"},{"key":"R20-6-20210202","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0920-9964(00)00174-2","article-title":"Low GSK-3 activity in frontal cortex of schizophrenic patients","volume":"52","author":"Kozlovsky","year":"2001","journal-title":"Schizophr Res"},{"key":"R21-6-20210202","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0278-5846(02)00294-4","article-title":"Lack of effect of acute, subchronic, or chronic stress on glycogen synthase kinase-3beta protein levels in rat frontal cortex","volume":"26","author":"Kozlovsky","year":"2002","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R22-6-20210202","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1017\/S1461145703003353","article-title":"Lack of effect of mood stabilizers or neuroleptics on GSK-3 protein levels and GSK-3 activity","volume":"6","author":"Kozlovsky","year":"2003","journal-title":"Int J Neuropsychopharmacol"},{"key":"R23-6-20210202","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00702-004-0166-3","article-title":"Reduced GSK-3beta mRNA levels in postmortem dorsolateral prefrontal cortex of schizophrenic patients","volume":"111","author":"Kozlovsky","year":"2004","journal-title":"J Neural Transm"},{"key":"R24-6-20210202","doi-asserted-by":"crossref","first-page":"8987","DOI":"10.1073\/pnas.1432926100","article-title":"Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia","volume":"100","author":"Miyakawa","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R25-6-20210202","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.schres.2004.02.020","article-title":"GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients","volume":"71","author":"Nadri","year":"2004","journal-title":"Schizophr Res"},{"key":"R26-6-20210202","doi-asserted-by":"crossref","first-page":"6791","DOI":"10.1523\/JNEUROSCI.4753-03.2004","article-title":"Glycogen synthase kinase-3beta haploinsufficiency mimics the behavioral and molecular effects of lithium","volume":"24","author":"O'Brien","year":"2004","journal-title":"J Neurosci"},{"key":"R27-6-20210202","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0166-4328(88)90019-8","article-title":"Susceptibility to pilocarpine-induced seizures in rats increases with age","volume":"31","author":"Patel","year":"1988","journal-title":"Behav Brain Res"},{"key":"R28-6-20210202","first-page":"8.10A.1","article-title":"Current protocols in neuroscience","author":"Porsolt","year":"2001"},{"key":"R29-6-20210202","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"R30-6-20210202","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0278-5846(01)00154-3","article-title":"The mechanism of lithium action: state of the art, ten years later","volume":"25","author":"Shaldubina","year":"2001","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"R32-6-20210202","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s007020070081","article-title":"Scyllo-inositol in post-mortem brain of bipolar, unipolar and schizophrenic patients","volume":"107","author":"Shapiro","year":"2000","journal-title":"J Neural Transm"},{"key":"R33-6-20210202","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1016\/S0960-9822(02)70790-2","article-title":"Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells","volume":"6","author":"Stambolic","year":"1996","journal-title":"Curr Biol"},{"key":"R34-6-20210202","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology (Berl)"},{"key":"R35-6-20210202","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1126\/science.1121613","article-title":"Nuclear receptor Rev-erbalpha is a critical lithium-sensitive component of the circadian clock","volume":"311","author":"Yin","year":"2006","journal-title":"Science"}],"container-title":["Behavioural Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/FBP.0b013e3282feb099","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:07:39Z","timestamp":1786036059000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00008877-200805000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/fbp.0b013e3282feb099","relation":{},"ISSN":["0955-8810"],"issn-type":[{"value":"0955-8810","type":"print"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}