{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:16:40Z","timestamp":1786119400735,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1097\/fbp.0b013e3283323c90","type":"journal-article","created":{"date-parts":[[2009,11,19]],"date-time":"2009-11-19T12:43:59Z","timestamp":1258634639000},"page":"755-758","source":"Crossref","is-referenced-by-count":29,"title":["Ranolazine attenuates behavioral signs of neuropathic pain"],"prefix":"10.1097","volume":"20","author":[{"given":"Harry J.","family":"Gould","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Garrett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee R.","family":"Donahue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Diamond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley K.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20210202","doi-asserted-by":"crossref","first-page":"8559","DOI":"10.1523\/JNEUROSCI.19-19-08589.1999","article-title":"Membrane potential oscillations in dorsal root ganglion neurons: role in normal electrogenesis and neuropathic pain","volume":"19","author":"Amir","year":"1999","journal-title":"J Neurosci"},{"key":"R2-9-20210202","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1523\/JNEUROSCI.22-03-01187.2002","article-title":"Burst discharge in primary sensory neurons: triggered by subthreshold oscillations, maintained by depolarizing afterpotentials","volume":"22","author":"Amir","year":"2002a","journal-title":"J Neurosci"},{"key":"R3-9-20210202","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1093\/brain\/awf037","article-title":"Oscillatory mechanism in primary sensory neurons","volume":"125","author":"Amir","year":"2002b","journal-title":"Brain"},{"key":"R4-9-20210202","first-page":"285","article-title":"Neuropathic pain: pathophysiology and treatment, progress in pain research and management (Vol 21)","author":"Backonja","year":"2001"},{"key":"R5-9-20210202","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/hrt.2005.078790","article-title":"Inhibition of the late sodium current as a potential cardioprotective principle: effects of the late sodium current inhibitor ranolazine","volume":"92","author":"Belardinelli","year":"2006","journal-title":"Heart"},{"key":"R6-9-20210202","first-page":"201","article-title":"Textbook of pain (Vol 3)","author":"Bennett","year":"1994"},{"key":"R7-9-20210202","first-page":"CD003345","article-title":"Systemic administration of local anesthetic agents to relieve neuropathic pain","volume":"19","author":"Challapalli","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"R8-9-20210202","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0165-0270(94)90144-9","article-title":"Quantitative assessment of tactile allodynia in the rat paw","volume":"53","author":"Chaplan","year":"1994","journal-title":"J Neurosci Methods"},{"key":"R9-9-20210202","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SNC9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"R10-9-20210202","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0304-3959(00)00276-1","article-title":"Spared nerve injury: an animal model of persistent peripheral neuropathic pain","volume":"87","author":"Decosterd","year":"2000","journal-title":"Pain"},{"key":"R11-9-20210202","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.jpain.2005.09.006","article-title":"Sodium channels and mechanisms of neuropathic pain","volume":"7","author":"Devor","year":"2006","journal-title":"J Pain"},{"key":"R12-9-20210202","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/brain\/awh514","article-title":"Gain-of-function mutation in Nav 1.7 in familial erythromelalgia induces bursting of sensory neurons","volume":"128","author":"Dib-Hajj","year":"2005","journal-title":"Brain"},{"key":"R13-9-20210202","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.tins.2007.08.004","article-title":"From genes to pain: Nav 1.7 and human pain disorders","volume":"30","author":"Dib-Hajj","year":"2007","journal-title":"Trends Neurosci"},{"key":"R14-9-20210202","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1172\/JCI33297","article-title":"Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders","volume":"117","author":"Drenth","year":"2007","journal-title":"J Clin Invest"},{"key":"R15-9-20210202","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0014-2999(02)02792-9","article-title":"A comparison of the antinociceptive effects of voltage-activated Na+ channel blockers in two rat models of neuropathic pain","volume":"458","author":"Erichsen","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"R16-9-20210202","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.neuron.2006.10.006","article-title":"SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes","volume":"52","author":"Fertleman","year":"2006","journal-title":"Neuron"},{"key":"R17-9-20210202","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1468-2982.2008.01800.x","article-title":"Neuropsychiatric side-effects of lidocaine: examples from the treatment of headache and a review","volume":"29","author":"Gil-Gouveia","year":"2009","journal-title":"Cephalalgia"},{"key":"R18-9-20210202","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1399-0004.2007.00790.x","article-title":"Loss-of-function mutations in the NaV 1.7 gene underlie congenital indifference to pain in multiple human populations","volume":"71","author":"Goldberg","year":"2007","journal-title":"Clin Genet"},{"key":"R19-9-20210202","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0006-8993(99)02216-7","article-title":"A possible role for nerve growth factor in the augmentation of sodium channels in models of chronic pain","volume":"854","author":"Gould","year":"2000","journal-title":"Brain Res"},{"key":"R20-9-20210202","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jpain.2004.04.005","article-title":"Ibuprofen blocks changes in NaV 1.7 and 1.8 sodium channels associated with complete Freund's adjuvant-induced inflammation in rat","volume":"5","author":"Gould","year":"2004","journal-title":"J Pain"},{"key":"R21-9-20210202","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.yjmcc.2008.03.019","article-title":"Late sodium current inhibition as a new cardioprotective approach","volume":"44","author":"Hale","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"R22-9-20210202","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1113\/jphysiol.2004.079681","article-title":"Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart","volume":"564","author":"Haufe","year":"2005","journal-title":"J Physiol"},{"key":"R23-9-20210202","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.pain.2007.09.016","article-title":"Intrathecal neuropeptide Y reduces behavioral and molecular markers of inflammatory or neuropathic pain","volume":"137","author":"Intondi","year":"2008","journal-title":"Pain"},{"key":"R24-9-20210202","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1007\/s004240050079","article-title":"Tetrodotoxin-sensitive inactivation-resistant sodium channels in pacemaker cells influence heart rate","volume":"431","author":"Ju","year":"1996a","journal-title":"Pflugers Arch"},{"key":"R25-9-20210202","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1113\/jphysiol.1996.sp021772","article-title":"Hypoxia increases persistent sodium current in rat ventricular myocytes","volume":"497","author":"Ju","year":"1996b","journal-title":"J Physiol"},{"key":"R26-9-20210202","first-page":"123","article-title":"Reflex sympathetic dystrophy: a reappraisal, progress in pain research and management (Vol 6)","author":"Koltzenburg","year":"1996"},{"key":"R27-9-20210202","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1001\/archinte.166.12.1325-b","article-title":"Mechanism of action of ranolazine","volume":"166","author":"Marx","year":"2006","journal-title":"Arch Intern Med"},{"key":"R28-9-20210202","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1001\/archinte.165.22.2587","article-title":"The case for medical treatment in chronic stable coronary artery disease","volume":"165","author":"Nash","year":"2005","journal-title":"Arch Intern Med"},{"key":"R29-9-20210202","doi-asserted-by":"crossref","first-page":"12706","DOI":"10.1073\/pnas.0404915101","article-title":"Nociceptor-specific gene deletion reveals a major role for Nav 1.7 (PN1) in acute and inflammatory pain","volume":"101","author":"Nassar","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"R31-9-20210202","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/j.1742-1241.2007.01348.x","article-title":"Ranolazine: a novel agent that improves dysfunctional sodium channels","volume":"61","author":"Pham","year":"2007","journal-title":"Int J Clin Pract"},{"key":"R32-9-20210202","doi-asserted-by":"crossref","first-page":"449","DOI":"10.4161\/chan.2.6.7362","article-title":"Block of tetrodotoxin-sensitive, NaV 1.7, and tetrodotoxin-resistant, NaV 1.8, Na+ channels by ranolazine","volume":"2","author":"Rajamani","year":"2008","journal-title":"Channels"},{"key":"R33-9-20210202","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.yjmcc.2008.03.006","article-title":"Ranolazine improves diastolic dysfunction in isolated myocardium from failing human hearts--role of late sodium current and intracellular ion accumulation","volume":"45","author":"Sossalla","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"R34-9-20210202","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.pain.2006.12.018","article-title":"Neuropeptide Y acts at Y1 receptors in the rostral ventral medulla to inhibit neuropathic pain","volume":"131","author":"Taylor","year":"2007","journal-title":"Pain"},{"key":"R35-9-20210202","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1124\/mol.107.041541","article-title":"State- and use-dependent block of muscle NaV 1.4, and neuronal Nav 1.7 voltage-gated Na+ channel isoforms by ranolazine","volume":"73","author":"Wang","year":"2008","journal-title":"Mol Pharmacol"},{"key":"R36-9-20210202","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/444831a","article-title":"A channel sets the gain on pain","volume":"444","author":"Waxman","year":"2006","journal-title":"Nature"},{"key":"R37-9-20210202","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0014-2999(01)01303-6","article-title":"Pathobiology of neuropathic pain","volume":"429","author":"Zimmerman","year":"2001","journal-title":"Eur J Pharmacol"}],"container-title":["Behavioural Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00008877-200912000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:09:21Z","timestamp":1786039761000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00008877-200912000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":36,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/fbp.0b013e3283323c90","relation":{},"ISSN":["0955-8810"],"issn-type":[{"value":"0955-8810","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}