{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:03:33Z","timestamp":1786118613194,"version":"build-2736575974"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1097\/fjc.0b013e31802ef532","type":"journal-article","created":{"date-parts":[[2007,3,27]],"date-time":"2007-03-27T04:04:09Z","timestamp":1174968249000},"page":"117-121","source":"Crossref","is-referenced-by-count":47,"title":["Anti-ischemic Effects of Fasudil, a Specific Rho-Kinase Inhibitor, in Patients With Stable Effort Angina"],"prefix":"10.1097","volume":"49","author":[{"given":"Yoshihiro","family":"Fukumoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Mohri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kosuke","family":"Inokuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Ito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoji","family":"Hirakawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Masumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Hirooka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takeshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-1-20210208","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1161\/01.CIR.0000047041.66447.29","article-title":"ACC\/AHA 2002 guideline update for the management of patients with chronic stable angina-summary article: a report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina).","volume":"107","author":"Gibbons","year":"2003","journal-title":"Circulation"},{"key":"R2-1-20210208","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/S0008-6363(96)00178-2","article-title":"Tyrosine kinase inhibitor suppresses the (re) stenotic changes of the coronary artery after balloon injury in pigs.","volume":"32","author":"Fukumoto","year":"1996","journal-title":"Cardiovasc Res"},{"key":"R3-1-20210208","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/00005344-200501000-00015","article-title":"Renin-angiotensin system intervention to prevent in-stent restenosis: an unclosed chapter.","volume":"45","author":"Langeveld","year":"2005","journal-title":"J Cardiovasc Pharmacol"},{"key":"R4-1-20210208","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1161\/01.CIR.101.11.1319","article-title":"Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1beta.","volume":"101","author":"Kandabashi","year":"2000","journal-title":"Circulation"},{"key":"R5-1-20210208","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/00005344-200203000-00001","article-title":"Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases.","volume":"39","author":"Shimokawa","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"R6-1-20210208","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1136\/hrt.2003.029470","article-title":"Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension.","volume":"91","author":"Fukumoto","year":"2005","journal-title":"Heart"},{"key":"R7-1-20210208","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/40187","article-title":"Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension.","volume":"389","author":"Uehata","year":"1997","journal-title":"Nature"},{"key":"R9-1-20210208","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1161\/hc1002.105938","article-title":"Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina.","volume":"105","author":"Masumoto","year":"2002","journal-title":"Circulation"},{"key":"R10-1-20210208","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0735-1097(02)02632-3","article-title":"Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm.","volume":"41","author":"Mohri","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"R11-1-20210208","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1097\/00005344-200211000-00013","article-title":"Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study.","volume":"40","author":"Shimokawa","year":"2002","journal-title":"J Cardiovasc Pharmacol"},{"key":"R12-1-20210208","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.jacc.2005.07.047","article-title":"Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial.","volume":"46","author":"Vicari","year":"2005","journal-title":"J Am Coll Cardiol"},{"key":"R13-1-20210208","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0008-6363(99)00144-3","article-title":"Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm.","volume":"43","author":"Shimokawa","year":"1999","journal-title":"Cardiovasc Res"},{"key":"R14-1-20210208","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors.","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"R15-1-20210208","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1111\/j.1469-7793.2000.0033m.x","article-title":"Inhibition of Rho-associated kinase blocks agonist-induced Ca2+ sensitization of myosin phosphorylation and force in guinea-pig ileum.","volume":"522","author":"Sward","year":"2000","journal-title":"J Physiol"},{"key":"R16-1-20210208","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1161\/01.ATV.0000176193.83629.c8","article-title":"Rho-kinase is an important therapeutic target in cardiovascular medicine.","volume":"25","author":"Shimokawa","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R17-1-20210208","doi-asserted-by":"crossref","first-page":"4357","DOI":"10.1161\/01.CIR.96.12.4357","article-title":"Enhanced myosin light chain phosphorylations as a central mechanism for coronary artery spasm in a swine model with interleukin-1beta.","volume":"96","author":"Katsumata","year":"1997","journal-title":"Circulation"},{"key":"R18-1-20210208","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1161\/01.ATV.20.11.2351","article-title":"Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo.","volume":"20","author":"Miyata","year":"2000","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R19-1-20210208","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/01.ATV.0000126678.93747.80","article-title":"Remnant lipoproteins from patients with sudden cardiac death enhance coronary vasospastic activity through upregulation of Rho-kinase.","volume":"24","author":"Oi","year":"2004","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R20-1-20210208","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/01.fjc.0000134775.76636.3f","article-title":"Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery.","volume":"44","author":"Inokuchi","year":"2004","journal-title":"J Cardiovasc Pharmacol"},{"key":"R21-1-20210208","doi-asserted-by":"crossref","first-page":"1724","DOI":"10.1038\/sj.bjp.0704410","article-title":"Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina.","volume":"134","author":"Utsunomiya","year":"2001","journal-title":"Br J Pharmacol"}],"container-title":["Journal of Cardiovascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00005344-200703000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:30:53Z","timestamp":1786033853000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005344-200703000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/fjc.0b013e31802ef532","relation":{},"ISSN":["0160-2446"],"issn-type":[{"value":"0160-2446","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}