{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T22:39:41Z","timestamp":1782167981869,"version":"3.54.5"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1097\/fjc.0b013e31819f1be1","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T12:49:45Z","timestamp":1242910185000},"page":"325-332","source":"Crossref","is-referenced-by-count":13,"title":["Chronotropic Effects of Azelnidipine, a Slow- and Long-acting Dihydropyridine-type Calcium Channel Blocker, in Anesthetized Dogs: A Comparison With Amlodipine"],"prefix":"10.1097","volume":"53","author":[{"given":"Michio","family":"Fujisawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Yorikane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigetoshi","family":"Chiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Koike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20210208","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1161\/01.CIR.92.5.1326","article-title":"Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.","volume":"92","author":"Furberg","year":"1995","journal-title":"Circulation"},{"key":"R2-7-20210208","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/jama.1996.03530300007004","article-title":"FDA gives calcium channel blockers clean bill of health but warns of short-acting nifedipine hazards.","volume":"275","author":"Marwick","year":"1996","journal-title":"JAMA"},{"key":"R3-7-20210208","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(97)05381-6","article-title":"Randomized double-blind comparison of placebo and active treatment for older patients with isolated systolic hypertension.","volume":"350","author":"Staessen","year":"1997","journal-title":"Lancet"},{"key":"R4-7-20210208","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/S0140-6736(04)16451-9","article-title":"Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomized trial.","volume":"363","author":"Julius","year":"2004","journal-title":"Lancet"},{"key":"R5-7-20210208","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0895-7061(01)02218-X","article-title":"The effects of dihydropyridine and phenylalkylamine calcium antagonist classes on autonomic function in hypertension: the VAMPHYRE study.","volume":"14","author":"Lefrandt","year":"2001","journal-title":"Am J Hypertens"},{"key":"R6-7-20210208","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1097\/00004872-200206000-00026","article-title":"Effects of selective angiotensin II receptor blockade on sympathetic nerve activity in primary hypertensive subjects.","volume":"20","author":"Struck","year":"2002","journal-title":"J Hypertens"},{"key":"R7-7-20210208","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0021-5198(19)40137-6","article-title":"Antihypertensive effects of CS-905, a novel dihydropyridine Ca++ channel blocker.","volume":"51","author":"Oizumi","year":"1989","journal-title":"Jpn J Pharmacol"},{"key":"R8-7-20210208","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1254\/jjp.53.264","article-title":"Antihypertensive effects of CS-905, a novel dihydropyridine calcium blocker, in conscious hypertensive dogs.","volume":"53","author":"Oizumi","year":"1990","journal-title":"Jpn J Pharmacol"},{"key":"R9-7-20210208","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1291\/hypres.26.201","article-title":"Azelnidipine and amlodipine: a comparison of their pharmacokinetics and effects on ambulatory blood pressure.","volume":"26","author":"Kuramoto","year":"2003","journal-title":"Hypertens Res"},{"key":"R10-7-20210208","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1291\/hypres.29.767","article-title":"Efficacy of azelnidipine on home blood pressure and pulse rate in patients with essential hypertension: comparison with amlodipine.","volume":"29","author":"Yamagishi","year":"2006","journal-title":"Hypertens Res"},{"key":"R11-7-20210208","first-page":"698","article-title":"Clinical study with azelnidipine in patients with essential hypertension. Antiarteriosclerotic and cardiac hypertrophy-inhibitory effects and influence on autonomic nervous activity.","volume":"57","author":"Nada","year":"2007","journal-title":"Arzneimittelforschung"},{"key":"R12-7-20210208","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1291\/hypres.28.1017","article-title":"Effects of a new calcium channel blocker, azelnidipine, on systemic hemodynamics and renal sympathetic nerve activity in spontaneously hypertensive rats.","volume":"28","author":"Shokoji","year":"2005","journal-title":"Hypertens Res"},{"key":"R13-7-20210208","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1291\/hypres.30.359","article-title":"Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats.","volume":"30","author":"Nakamoto","year":"2007","journal-title":"Hypertens Res"},{"key":"R14-7-20210208","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10641960601096745","article-title":"Long-acting calcium channel blocker, azelnidipine, increases endothelial nitric oxide synthase in the brain and inhibits sympathetic nerve activity.","volume":"29","author":"Kimura","year":"2007","journal-title":"Clin Exp Hypertens"},{"key":"R15-7-20210208","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.1097\/01.hjh.0000244956.47114.c1","article-title":"Enhancement of cardiac oxidative stress by tachycardia and its critical role in cardiac hypertrophy and fibrosis.","volume":"24","author":"Yamamoto","year":"2006","journal-title":"J Hypertens"},{"key":"R16-7-20210208","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/FJC.0b013e31804d1cf1","article-title":"Effects of new calcium channel blocker, azelnidipine, and amlodipine on baroreflex sensitivity and ambulatory blood pressure.","volume":"49","author":"Eguchi","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"R17-7-20210208","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1291\/hypres.29.943","article-title":"Tilting-induced decrease in systolic blood pressure in bedridden hypertensive elderly inpatients: effects of azelnidipine.","volume":"29","author":"Morimoto","year":"2006","journal-title":"Hypertens Res"},{"key":"R18-7-20210208","first-page":"21","article-title":"Direct perfusion of the sinus node: an experimental model for pharmacologic and electrophysiologic studies of the heart.","volume":"10","author":"James","year":"1962","journal-title":"Henry Ford Hosp Med Bull"},{"key":"R19-7-20210208","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1161\/01.RES.21.3.297","article-title":"Responses of the sino-atrial node to change in pressure in the sinus node artery.","volume":"21","author":"Hashimoto","year":"1967","journal-title":"Circ Res"},{"key":"R20-7-20210208","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1161\/01.RES.37.4.422","article-title":"Influence of cardiopulmonary vagal afferent activity on carotid chemoreceptor and baroreceptor reflexes in the dog.","volume":"37","author":"Koike","year":"1975","journal-title":"Circ Res"},{"key":"R21-7-20210208","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1113\/jphysiol.1971.sp009418","article-title":"Effects of graded pulsatile pressure on the reflex vasomotor responses elicited by changes of mean pressure in the perfused carotid sinus-aortic arch regions of the dog.","volume":"214","author":"Angell James","year":"1971","journal-title":"J Physiol"},{"key":"R22-7-20210208","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1152\/physrev.1993.73.1.197","article-title":"Cardiac pacemaking in the sinoatrial node.","volume":"73","author":"Irisawa","year":"1993","journal-title":"Physiol Rev"},{"key":"R23-7-20210208","doi-asserted-by":"crossref","first-page":"24B","DOI":"10.1016\/0002-9149(87)90078-6","article-title":"Differences in cardiovascular profile among calcium antagonists.","volume":"59","author":"Taira","year":"1987","journal-title":"Am J Cardiol"},{"key":"R24-7-20210208","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1007\/BF02630561","article-title":"Lacidipine, a new long-lasting dihydropyridine calcium antagonist, has high vascular selectivity against all intracardial variables.","volume":"8","author":"Motomura","year":"1993","journal-title":"Heart Vessels"},{"issue":"Suppl 3","key":"R25-7-20210208","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/BF00051613","article-title":"Pharmacological aspects of calcium channel blockers.","volume":"10","author":"Scholz","year":"1997","journal-title":"Cardiovasc Drugs Ther"},{"key":"R26-7-20210208","first-page":"1","article-title":"Azelnidipine, a long-acting calcium channel blocker with slow onset and high vascular affinity.","volume":"54","author":"Koike","year":"2002","journal-title":"Annu Rep Sankyo Res Lab"},{"key":"R28-7-20210208","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1113\/jphysiol.1971.sp009419","article-title":"The effects of altering mean pressure, pulse pressure and pulse frequency on the impulse activity in baro-receptor fibers from the aortic arch and right subclavian artery in the rabbit.","volume":"214","author":"Angel James","year":"1971","journal-title":"J Physiol"},{"key":"R29-7-20210208","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1253\/circj.67.139","article-title":"Clinical efficacy of efonidipine hydrochloride, a T-type calcium channel inhibitor, on sympathetic activities.","volume":"67","author":"Harada","year":"2003","journal-title":"Circ J"},{"key":"R30-7-20210208","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/00005344-199808000-00023","article-title":"Comparison of 24-hour blood pressure, heart rate, and autonomic nerve activity in hypertensive patients treated with cilnidipine or nifedipine retard.","volume":"32","author":"Minami","year":"1998","journal-title":"J Cardiovasc Pharmacol"}],"container-title":["Journal of Cardiovascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00005344-200904000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T01:45:03Z","timestamp":1618364703000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005344-200904000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/fjc.0b013e31819f1be1","relation":{},"ISSN":["0160-2446"],"issn-type":[{"value":"0160-2446","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}