{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:16:34Z","timestamp":1786119394417,"version":"build-2736575974"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,10]]},"DOI":"10.1097\/fjc.0b013e3181b76713","type":"journal-article","created":{"date-parts":[[2009,10,15]],"date-time":"2009-10-15T03:21:11Z","timestamp":1255576871000},"page":"327-334","source":"Crossref","is-referenced-by-count":34,"title":["Cardiac Hypertrophy During Hypercholesterolemia and Its Amelioration With Rosuvastatin and Amlodipine"],"prefix":"10.1097","volume":"54","author":[{"given":"Bum-Yong","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenze","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Palade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shree G","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawahar L","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210208","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/HCR.0b013e318192754e","article-title":"A review of lipid management in primary and secondary prevention.","volume":"29","author":"Dembowski","year":"2009","journal-title":"J Cardiopulm Rehabil Prev"},{"key":"R2-8-20210208","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0735-1097(97)00158-7","article-title":"Preservation of endogenous antioxidant activity and inhibition of lipid peroxidation as common mechanisms of antiatherosclerotic effects of vitamin E, lovastatin and amlodipine.","volume":"30","author":"Chen","year":"1997","journal-title":"J Am Coll Cardiol"},{"key":"R3-8-20210208","doi-asserted-by":"crossref","first-page":"2458","DOI":"10.1161\/CIRCULATIONAHA.108.773747","article-title":"Effect of rosuvastatin therapy on coronary artery stenoses assessed by quantitative coronary angiography: a study to evaluate the effect of rosuvastatin on intravascular ultrasound-derived coronary atheroma burden.","volume":"117","author":"Ballantyne","year":"2008","journal-title":"Circulation"},{"key":"R4-8-20210208","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00045391-200311000-00006","article-title":"Calcium antagonists and atherosclerosis protection in hypertension.","volume":"10","author":"Hernandez","year":"2003","journal-title":"Am J Ther"},{"key":"R5-8-20210208","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1291\/hypres.31.1977","article-title":"Inhibition of cardiac remodeling by pravastatin is associated with amelioration of endoplasmic reticulum stress.","volume":"31","author":"Zhao","year":"2008","journal-title":"Hypertens Res"},{"key":"R6-8-20210208","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1016\/S0735-1097(02)02375-6","article-title":"Impact of hydroxymethylglutaryl coenzyme a reductase inhibition on left ventricular remodeling after myocardial infarction: an experimental serial cardiac magnetic resonance imaging study.","volume":"40","author":"Nahrendorf","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"R7-8-20210208","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1161\/01.CIR.104.3.317","article-title":"Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy.","volume":"104","author":"Patel","year":"2001","journal-title":"Circulation"},{"key":"R8-8-20210208","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1161\/hc0702.104164","article-title":"Fluvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, attenuates left ventricular remodeling and failure after experimental myocardial infarction.","volume":"105","author":"Hayashidani","year":"2002","journal-title":"Circulation"},{"key":"R9-8-20210208","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1097\/HJH.0b013e3280e126d5","article-title":"Fibroblast apoptosis precedes cardiomyocyte mass reduction during left ventricular remodeling in hypertensive rats treated with amlodipine.","volume":"25","author":"Duguay","year":"2007","journal-title":"J Hypertens"},{"key":"R10-8-20210208","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.RES.0000196564.18314.23","article-title":"Rho GTPases, statins, and nitric oxide.","volume":"97","author":"Rikitake","year":"2005","journal-title":"Circ Res"},{"key":"R11-8-20210208","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1291\/hypres.18.47","article-title":"Effects of Ca-antagonists on oxidative susceptibility of low density lipoprotein (LDL).","volume":"18","author":"Yoshida","year":"1995","journal-title":"Hypertens Res"},{"key":"R12-8-20210208","doi-asserted-by":"crossref","first-page":"358","DOI":"10.2353\/ajpath.2008.071126","article-title":"Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment.","volume":"173","author":"Cheng","year":"2008","journal-title":"Am J Pathol"},{"key":"R13-8-20210208","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11010-008-9803-8","article-title":"Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats.","volume":"317","author":"Zhao","year":"2008","journal-title":"Mol Cell Biochem"},{"key":"R14-8-20210208","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.yjmcc.2007.10.009","article-title":"LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice.","volume":"44","author":"Hu","year":"2008","journal-title":"J Mol Cell Cardiol"},{"key":"R15-8-20210208","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1161\/HYPERTENSIONAHA.108.115287","article-title":"Modulation of angiotensin II-mediated hypertension and cardiac remodeling by lectin-like oxidized low-density lipoprotein receptor-1 deletion.","volume":"52","author":"Hu","year":"2008","journal-title":"Hypertension"},{"key":"R16-8-20210208","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.cardiores.2005.09.006","article-title":"Lectin-like, oxidized low-density lipoprotein receptor-1 (LOX-1): a critical player in the development of atherosclerosis and related disorders.","volume":"69","author":"Mehta","year":"2006","journal-title":"Cardiovasc Res"},{"key":"R17-8-20210208","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.neurobiolaging.2004.06.018","article-title":"Cardiovascular functional phenotypes and pharmacological responses in apolipoprotein E deficient mice.","volume":"26","author":"Wang","year":"2005","journal-title":"Neurobiol Aging"},{"key":"R18-8-20210208","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s00380-008-1066-5","article-title":"Effects of dietary sodium on reactive oxygen species formation and endothelial dysfunction in low-density lipoprotein receptor-deficient mice on high-fat diet.","volume":"23","author":"Ketonen","year":"2008","journal-title":"Heart Vessels"},{"key":"R19-8-20210208","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1083\/jcb.111.2.347","article-title":"Tissue-specific sorting of the human LDL receptor in polarized epithelia of transgenic mice.","volume":"111","author":"Pathak","year":"1990","journal-title":"J Cell Biol"},{"key":"R21-8-20210208","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.bbrc.2008.12.143","article-title":"LOX-1 dependent overexpression of immunoglobulins in cardiomyocytes in response to angiotensin II.","volume":"379","author":"Kang","year":"2009","journal-title":"Biochem Biophys Res Commun"},{"key":"R22-8-20210208","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1253\/circj.72.538","article-title":"Impact of statin therapy on left ventricular function and carotid arterial stiffness in patients with hypercholesterolemia.","volume":"72","author":"Mizuguchi","year":"2008","journal-title":"Circ J"},{"key":"R23-8-20210208","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1194\/jlr.M500550-JLR200","article-title":"Distinct modulation of angiotensin II-induced early left ventricular hypertrophic gene programming by dietary fat type.","volume":"47","author":"Foldes","year":"2006","journal-title":"J Lipid Res"},{"key":"R24-8-20210208","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1161\/01.CIR.96.3.922","article-title":"Increase in angiotensin II type 1 receptor expression immediately after ischemia-reperfusion in isolated rat hearts.","volume":"96","author":"Yang","year":"1997","journal-title":"Circulation"},{"key":"R25-8-20210208","doi-asserted-by":"crossref","first-page":"H586","DOI":"10.1152\/ajpheart.00474.2004","article-title":"Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor.","volume":"289","author":"Bridgman","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R26-8-20210208","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1067\/mlc.2000.105617","article-title":"Angiotensin II-induced cardiomyocyte hypertrophy and cardiac fibrosis in stroke-prone spontaneously hypertensive rats.","volume":"135","author":"Ikeda","year":"2000","journal-title":"J Lab Clin Med"},{"key":"R27-8-20210208","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1073\/pnas.97.2.931","article-title":"Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.","volume":"97","author":"Paradis","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"R28-8-20210208","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.atherosclerosis.2005.04.016","article-title":"Cross-talk between dyslipidemia and renin-angiotensin system and the role of LOX-1 and MAPK in atherogenesis studies with the combined use of rosuvastatin and candesartan.","volume":"84","author":"Chen","year":"2006","journal-title":"Atherosclerosis"},{"key":"R29-8-20210208","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1161\/01.RES.84.9.1043","article-title":"Upregulation of endothelial receptor for oxidized low-density lipoprotein (LOX-1) in cultured human coronary artery endothelial cells by angiotensin II type 1 receptor activation.","volume":"84","author":"Li","year":"1999","journal-title":"Circ Res"},{"key":"R30-8-20210208","doi-asserted-by":"crossref","first-page":"10226","DOI":"10.1074\/jbc.M708820200","article-title":"Regulation of TGFbeta1-mediated collagen formation by LOX-1: studies based on forced overexpression of TGFbeta1 in wild-type and LOX-1 knock-out mouse cardiac fibroblasts.","volume":"283","author":"Hu","year":"2008","journal-title":"J Biol Chem"},{"key":"R31-8-20210208","doi-asserted-by":"crossref","first-page":"110","DOI":"10.2174\/138161209787185742","article-title":"NAD(+), sirtuins, and cardiovascular disease.","volume":"15","author":"Borradaile","year":"2009","journal-title":"Curr Pharm Des"},{"key":"R32-8-20210208","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1161\/01.HYP.31.1.283","article-title":"Angiotensin II stimulates synthesis of endothelial nitric oxide synthase.","volume":"31","author":"Hennington","year":"1998","journal-title":"Hypertension"},{"key":"R33-8-20210208","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.cardiores.2007.04.031","article-title":"Cardiomyocytes as effectors of nitric oxide signalling.","volume":"75","author":"Seddon","year":"2007","journal-title":"Cardiovasc Res"},{"key":"R34-8-20210208","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1124\/jpet.102.034959","article-title":"Statins modulate oxidized low-density lipoprotein-mediated adhesion molecule expression in human coronary artery endothelial cells: role of LOX-1.","volume":"302","author":"Li","year":"2002","journal-title":"J Pharmacol Exp Ther"},{"key":"R35-8-20210208","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1210\/en.2006-1355","article-title":"Rosuvastatin, a 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor, decreases cardiac oxidative stress and remodeling in Ren2 transgenic rats.","volume":"148","author":"Habibi","year":"2007","journal-title":"Endocrinology"},{"key":"R36-8-20210208","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/FJC.0b013e31803d35ce","article-title":"Angiotensin II type 1 receptor expression in polymorphonuclear leukocytes from high-risk subjects: changes after treatment with simvastatin.","volume":"49","author":"Marino","year":"2007","journal-title":"J Cardiovasc Pharmacol"},{"key":"R37-8-20210208","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.lfs.2004.04.004","article-title":"Amlodipine decreases fibrosis and cardiac hypertrophy in spontaneously hypertensive rats: persistent effects after withdrawal.","volume":"75","author":"Sevilla","year":"2004","journal-title":"Life Sci"},{"key":"R38-8-20210208","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/j.bbrc.2004.12.112","article-title":"Amlodipine ameliorates myocardial hypertrophy by inhibiting EGFR phosphorylation.","volume":"327","author":"Liao","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R39-8-20210208","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1291\/hypres.29.105","article-title":"Calcium channel blockers reduce angiotensin II-induced superoxide generation and inhibit lectin-like oxidized low-density lipoprotein receptor-1 expression in endothelial cells.","volume":"29","author":"Toba","year":"2006","journal-title":"Hypertens Res"},{"key":"R40-8-20210208","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1254\/jphs.SC0080027","article-title":"Decreased expression of angiotensin II type 1 and type 2 receptors in the brain after long-term administration of antihypertensive drugs in stroke-prone spontaneously hypertensive rat.","volume":"106","author":"Nishida","year":"2008","journal-title":"J Pharmacol Sci"},{"key":"R41-8-20210208","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1161\/01.HYP.0000164570.20420.67","article-title":"Fructose-induced fatty liver disease: hepatic effects of blood pressure and plasma triglyceride reduction.","volume":"45","author":"Ackerman","year":"2005","journal-title":"Hypertension"}],"container-title":["Journal of Cardiovascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/FJC.0b013e3181b76713","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:09:09Z","timestamp":1786039749000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005344-200910000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/fjc.0b013e3181b76713","relation":{},"ISSN":["0160-2446"],"issn-type":[{"value":"0160-2446","type":"print"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}