{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T03:36:11Z","timestamp":1768880171547,"version":"3.49.0"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/fjc.0b013e3181cf0090","type":"journal-article","created":{"date-parts":[[2010,3,26]],"date-time":"2010-03-26T09:42:01Z","timestamp":1269596521000},"page":"248-254","source":"Crossref","is-referenced-by-count":36,"title":["Uncoupling the Coupled Calcium and Zinc Dyshomeostasis in Cardiac Myocytes and Mitochondria Seen in Aldosteronism"],"prefix":"10.1097","volume":"55","author":[{"given":"German","family":"Kamalov","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Ahokas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyuan","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tieqiang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atta U","family":"Shahbaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patti L","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syamal K","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan C","family":"Gerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl T","family":"Weber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-5-20210208","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1161\/01.CIR.89.1.151","article-title":"Structural basis of end-stage failure in ischemic cardiomyopathy in humans.","volume":"89","author":"Beltrami","year":"1994","journal-title":"Circulation"},{"key":"R3-5-20210208","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0002-9149(01)02341-4","article-title":"Risk stratification using a combination of cardiac troponin T and brain natriuretic peptide in patients hospitalized for worsening chronic heart failure.","volume":"89","author":"Ishii","year":"2002","journal-title":"Am J Cardiol"},{"key":"R4-5-20210208","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1253\/circj.71.1047","article-title":"Persistently increased serum concentrations of cardiac troponin in patients with acutely decompensated heart failure are predictive of adverse outcomes.","volume":"71","author":"Kuwabara","year":"2007","journal-title":"Circ J"},{"key":"R5-5-20210208","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1056\/NEJMoa0706824","article-title":"Cardiac troponin and outcome in acute heart failure.","volume":"358","author":"Peacock","year":"2008","journal-title":"N Engl J Med"},{"key":"R7-5-20210208","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1007\/s11906-006-0010-2","article-title":"Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease.","volume":"8","author":"Chen","year":"2006","journal-title":"Curr Hypertens Rep"},{"key":"R8-5-20210208","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.mco.0000222103.29009.70","article-title":"Angiotensin II as candidate of cardiac cachexia.","volume":"9","author":"Delafontaine","year":"2006","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"R9-5-20210208","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1161\/01.RES.69.5.1185","article-title":"Cardiac myocyte necrosis induced by angiotensin II.","volume":"69","author":"Tan","year":"1991","journal-title":"Circ Res"},{"key":"R10-5-20210208","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1124\/jpet.109.153213","article-title":"Mitochondrial permeability transition pore opening as a promising therapeutic target in cardiac diseases.","volume":"330","author":"Javadov","year":"2009","journal-title":"J Pharmacol Exp Ther"},{"key":"R11-5-20210208","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1161\/01.RES.65.3.657","article-title":"Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis.","volume":"65","author":"Benjamin","year":"1989","journal-title":"Circ Res"},{"key":"R12-5-20210208","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0022-2828(77)90046-3","article-title":"Effect of zinc on acute and chronic isoproterenol induced heart injury.","volume":"9","author":"Chvapil","year":"1977","journal-title":"J Mol Cell Cardiol"},{"key":"R13-5-20210208","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI31060","article-title":"Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure.","volume":"117","author":"Nakayama","year":"2007","journal-title":"J Clin Invest"},{"key":"R14-5-20210208","doi-asserted-by":"crossref","first-page":"H1227","DOI":"10.1152\/ajpheart.00610.2008","article-title":"Exogenous zinc protects cardiac cells from reperfusion injury by targeting mitochondrial permeability transition pore through inactivation of glycogen synthase kinase-3b.","volume":"295","author":"Chanoit","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R15-5-20210208","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1042\/BST0340232","article-title":"Calcium, mitochondria and reperfusion injury: a pore way to die.","volume":"34","author":"Halestrap","year":"2006","journal-title":"Biochem Soc Trans"},{"key":"R16-5-20210208","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1124\/jpet.107.119644","article-title":"Protective role of intracellular zinc in myocardial ischemia\/reperfusion is associated with preservation of protein kinase C isoforms.","volume":"321","author":"Karagulova","year":"2007","journal-title":"J Pharmacol Exp Ther"},{"key":"R17-5-20210208","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/FJC.0b013e3181833eb8","article-title":"Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism.","volume":"52","author":"Gandhi","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"R18-5-20210208","first-page":"414","article-title":"Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism.","volume":"53","author":"Kamalov","year":"2009","journal-title":"J Cardiovasc Pharmacol"},{"key":"R19-5-20210208","doi-asserted-by":"crossref","first-page":"H385","DOI":"10.1152\/ajpheart.00593.2009","article-title":"Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. 2009.","volume":"298","author":"Kamalov","year":"2010","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R20-5-20210208","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.RES.67.6.1355","article-title":"Remodeling of the rat right and left ventricle in experimental hypertension.","volume":"67","author":"Brilla","year":"1990","journal-title":"Circ Res"},{"key":"R21-5-20210208","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/S0008-6363(97)00097-7","article-title":"Fibrosis of atria and great vessels in response to angiotensin II or aldosterone infusion.","volume":"35","author":"Sun","year":"1997","journal-title":"Cardiovasc Res"},{"key":"R22-5-20210208","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/MAJ.0b013e3181aaee63","article-title":"Nutrient dyshomeostasis in congestive heart failure.","volume":"338","author":"Kamalov","year":"2009","journal-title":"Am J Med Sci"},{"key":"R23-5-20210208","doi-asserted-by":"crossref","first-page":"H2023","DOI":"10.1152\/ajpheart.00477.2004","article-title":"Loss of bone minerals and strength in rats with aldosteronism.","volume":"287","author":"Chhokar","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R24-5-20210208","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1161\/01.CIR.0000155621.10213.06","article-title":"Hyperparathyroidism and the calcium paradox of aldosteronism.","volume":"111","author":"Chhokar","year":"2005","journal-title":"Circulation"},{"key":"R25-5-20210208","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00000441-200608000-00004","article-title":"Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements.","volume":"332","author":"Goodwin","year":"2006","journal-title":"Am J Med Sci"},{"key":"R26-5-20210208","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/MAJ.0b013e318134f013","article-title":"Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism.","volume":"335","author":"Selektor","year":"2008","journal-title":"Am J Med Sci"},{"key":"R27-5-20210208","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1161\/01.CIR.0000151516.84238.37","article-title":"Aldosteronism and a proinflammatory vascular phenotype. Role of Mg2+, Ca2+ and H2O2 in peripheral blood mononuclear cells.","volume":"111","author":"Ahokas","year":"2005","journal-title":"Circulation"},{"key":"R28-5-20210208","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1016\/S0002-9440(10)64454-9","article-title":"Aldosterone-induced inflammation in the rat heart. Role of oxidative stress.","volume":"161","author":"Sun","year":"2002","journal-title":"Am J Pathol"},{"key":"R29-5-20210208","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0006-2952(99)00301-9","article-title":"Regulation of metallothionein gene expression by oxidative stress and metal ions.","volume":"59","author":"Andrews","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"R30-5-20210208","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1161\/01.HYP.0000118586.38323.5b","article-title":"From inflammation to fibrosis: a stiff stretch of highway.","volume":"43","author":"Weber","year":"2004","journal-title":"Hypertension"},{"key":"R31-5-20210208","doi-asserted-by":"crossref","first-page":"H2361","DOI":"10.1152\/ajpheart.00200.2007","article-title":"Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone.","volume":"293","author":"Thomas","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R32-5-20210208","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1097\/FJC.0b013e318165b96e","article-title":"Tissue 65Zinc translocation in a rat model of chronic aldosteronism.","volume":"51","author":"Selektor","year":"2008","journal-title":"J Cardiovasc Pharmacol"},{"key":"R33-5-20210208","doi-asserted-by":"crossref","first-page":"E124","DOI":"10.1161\/01.RES.0000102404.81461.25","article-title":"Aldosteronism and peripheral blood mononuclear cell activation. A neuroendocrine-immune interface.","volume":"93","author":"Ahokas","year":"2003","journal-title":"Circ Res"},{"key":"R34-5-20210208","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0022-1759(96)00244-X","article-title":"A highly sensitive fluorescent micro-assay of H2O2 release from activated human leukocytes using a dihydroxyphenoxazine derivative.","volume":"202","author":"Mohanty","year":"1997","journal-title":"J Immunol Methods"},{"key":"R35-5-20210208","doi-asserted-by":"crossref","first-page":"H286","DOI":"10.1152\/ajpheart.00535.2005","article-title":"Calcium paradox of aldosteronism and the role of the parathyroid glands.","volume":"290","author":"Vidal","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R36-5-20210208","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1073\/pnas.96.5.1910","article-title":"Selenium redox biochemistry of zinc-sulfur coordination sites in proteins and enzymes.","volume":"96","author":"Jacob","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R37-5-20210208","doi-asserted-by":"crossref","first-page":"S1455","DOI":"10.1093\/jn\/130.5.1455S","article-title":"The function of zinc metallothionein: a link between cellular zinc and redox state.","volume":"130","author":"Maret","year":"2000","journal-title":"J Nutr"},{"key":"R38-5-20210208","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0014-4886(87)90137-3","article-title":"Excessive intracellular zinc accumulation in cardiac and skeletal muscles of dystrophic hamsters.","volume":"95","author":"Crawford","year":"1987","journal-title":"Exp Neurol"},{"key":"R39-5-20210208","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1177\/174182679600300601","article-title":"Nutritional status and plasma trace elements in peripartum cardiomyopathy. A comparative study in Niger.","volume":"3","author":"Cenac","year":"1996","journal-title":"J Cardiovasc Risk"},{"key":"R40-5-20210208","first-page":"397","article-title":"Are failured cardiomyopathies a zinc-deficit related disease? A study on Zn and Cu in patients with chronic failured dilated and hypertrophic cardiomyopathies.","volume":"89","author":"Ripa","year":"1998","journal-title":"Minerva Med"},{"key":"R41-5-20210208","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1600-079X.1999.tb00585.x","article-title":"Zinc accumulation in adriamycin-induced cardiomyopathy in rats: effects of melatonin, a cardioprotective antioxidant.","volume":"26","author":"Morishima","year":"1999","journal-title":"J Pineal Res"},{"key":"R42-5-20210208","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1023\/A:1009264426047","article-title":"Relation between trace element levels in plasma and myocardium during coxsackievirus B3 myocarditis in the mouse.","volume":"13","author":"Funseth","year":"2000","journal-title":"Biometals"},{"key":"R43-5-20210208","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/s12011-008-8151-6","article-title":"The study of Cu and Zn serum levels in idiopathic dilated cardiomyopathy (IDCMP) patients and its comparison with healthy volunteers.","volume":"125","author":"Salehifar","year":"2008","journal-title":"Biol Trace Elem Res"},{"key":"R44-5-20210208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/BTER:107:1:001","article-title":"Significance of serum trace element status in patients with rheumatic heart disease: a prospective study.","volume":"107","author":"Kosar","year":"2005","journal-title":"Biol Trace Elem Res"},{"key":"R45-5-20210208","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/BF02698082","article-title":"Role of zinc in regulation of arterial blood pressure and in the etiopathogenesis of arterial hypertension.","volume":"117","author":"Tubek","year":"2007","journal-title":"Biol Trace Elem Res"},{"key":"R46-5-20210208","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1161\/ATVBAHA.108.162735","article-title":"Accumulation of zinc in human atherosclerotic lesions correlates with calcium levels but does not protect against protein oxidation.","volume":"28","author":"Stadler","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R47-5-20210208","first-page":"311","article-title":"Serum and other calcium fractions in patients after severe musculoskeletal trauma.","volume":"306-","author":"Henderson","year":"1992","journal-title":"Clin Orthop Relat Res"},{"key":"R48-5-20210208","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1001\/archsurg.1992.01420030027005","article-title":"Hypocalcemia during sepsis. Relationship to resuscitation and hemodynamics.","volume":"127","author":"Burchard","year":"1992","journal-title":"Arch Surg"},{"key":"R49-5-20210208","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1073\/pnas.90.9.3933","article-title":"Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?","volume":"90","author":"Song","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R50-5-20210208","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/bjs.1800810311","article-title":"Circulating intact parathyroid hormone levels in acute pancreatitis.","volume":"81","author":"McKay","year":"1994","journal-title":"Br J Surg"},{"key":"R51-5-20210208","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1046\/j.1365-2362.1997.2310778.x","article-title":"Serum levels of parathyroid hormone are related to the mortality and severity of illness in patients in the emergency department.","volume":"27","author":"Carlstedt","year":"1997","journal-title":"Eur J Clin Invest"},{"key":"R52-5-20210208","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/ajcn\/80.2.410","article-title":"Copper, selenium, zinc, and thiamine balances during continuous venovenous hemodiafiltration in critically ill patients.","volume":"80","author":"Berger","year":"2004","journal-title":"Am J Clin Nutr"},{"key":"R53-5-20210208","doi-asserted-by":"crossref","first-page":"R153","DOI":"10.1186\/cc5084","article-title":"Reduction of nosocomial pneumonia after major burns by trace element supplementation: aggregation of two randomised trials.","volume":"10","author":"Berger","year":"2006","journal-title":"Crit Care"},{"key":"R54-5-20210208","doi-asserted-by":"crossref","first-page":"R101","DOI":"10.1186\/cc6981","article-title":"Influence of early antioxidant supplements on clinical evolution and organ function in critically ill cardiac surgery, major trauma, and subarachnoid hemorrhage patients.","volume":"12","author":"Berger","year":"2008","journal-title":"Crit Care"},{"key":"R55-5-20210208","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/hrt.2008.147652","article-title":"Serum intact parathyroid hormone levels predict hospitalisation for heart failure.","volume":"95","author":"Sugimoto","year":"2009","journal-title":"Heart"},{"key":"R56-5-20210208","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1161\/CIRCULATIONAHA.105.537894","article-title":"Cardiac metallothionein induction plays the major role in the prevention of diabetic cardiomyopathy by zinc supplementation.","volume":"113","author":"Wang","year":"2006","journal-title":"Circulation"},{"key":"R57-5-20210208","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1097\/01.CCM.0000297954.45251.A9","article-title":"Early enteral supplementation with key pharmaconutrients improves sequential organ failure assessment score in critically ill patients with sepsis: outcome of a randomized, controlled, double-blind trial.","volume":"36","author":"Beale","year":"2008","journal-title":"Crit Care Med"},{"key":"R58-5-20210208","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nut.2007.10.004","article-title":"Depletion of plasma antioxidants in surgical intensive care unit patients requiring parenteral feeding: effects of parenteral nutrition with or without alanyl-glutamine dipeptide supplementation.","volume":"24","author":"Luo","year":"2008","journal-title":"Nutrition"},{"key":"R59-5-20210208","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1016\/j.nut.2008.05.024","article-title":"Monitoring the clinical introduction of a glutamine and antioxidant solution in critically ill trauma and burn patients.","volume":"24","author":"Soguel","year":"2008","journal-title":"Nutrition"},{"key":"R60-5-20210208","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/0115426506021005438","article-title":"Antioxidant micronutrients in major trauma and burns: evidence and practice.","volume":"21","author":"Berger","year":"2006","journal-title":"Nutr Clin Pract"},{"key":"R61-5-20210208","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1177\/0148607108327392","article-title":"Rationale and design of the pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial.","volume":"33","author":"Carcillo","year":"2009","journal-title":"JPEN J Parenter Enteral Nutr"},{"key":"R62-5-20210208","first-page":"H2497","article-title":"Zinc improves postischemic recovery of isolated rat hearts through inhibition of oxidative stress.","volume":"266","author":"Powell","year":"1994","journal-title":"Am J Physiol"},{"key":"R63-5-20210208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12011-007-0043-7","article-title":"Zinc supplementation or regulation of its homeostasis: advantages and threats.","volume":"119","author":"Tubek","year":"2007","journal-title":"Biol Trace Elem Res"},{"key":"R64-5-20210208","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1210\/jcem-6-2-117","article-title":"The general adaptation syndrome and the diseases of adaptation.","volume":"6","author":"Selye","year":"1946","journal-title":"J Clin Endocrinol"}],"container-title":["Journal of Cardiovascular Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/FJC.0b013e3181cf0090","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:18:32Z","timestamp":1620951512000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005344-201003000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":62,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/fjc.0b013e3181cf0090","relation":{},"ISSN":["0160-2446"],"issn-type":[{"value":"0160-2446","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}