{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T14:04:24Z","timestamp":1781359464567,"version":"3.54.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1097\/fpc.0000000000000282","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T17:44:54Z","timestamp":1493142294000},"page":"236-239","source":"Crossref","is-referenced-by-count":67,"title":["The effects of inherited NUDT15 polymorphisms on thiopurine active metabolites in Japanese children with acute lymphoblastic leukemia"],"prefix":"10.1097","volume":"27","author":[{"given":"Takaya","family":"Moriyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rina","family":"Nishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Nien","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Kihira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidemi","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nersting","family":"Jacob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiro","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyoshi","family":"Koh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroto","family":"Inaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun J.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-5-20210213","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrc2292","article-title":"Thiopurines in current medical practice: molecular mechanisms and contributions to therapy-related cancer","volume":"8","author":"Karran","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"R2-5-20210213","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1126\/science.2649979","article-title":"The purine path to chemotherapy","volume":"244","author":"Elion","year":"1989","journal-title":"Science"},{"key":"R3-5-20210213","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM199007053230104","article-title":"Systemic exposure to mercaptopurine as a prognostic factor in acute lymphocytic leukemia in children","volume":"323","author":"Koren","year":"1990","journal-title":"N Engl J Med"},{"key":"R4-5-20210213","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1200\/JCO.1989.7.12.1816","article-title":"Variable mercaptopurine metabolism and treatment outcome in childhood lymphoblastic leukemia","volume":"7","author":"Lennard","year":"1989","journal-title":"J Clin Oncol"},{"key":"R5-5-20210213","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1182\/blood-2014-01-552166","article-title":"6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children\u2019s Oncology Group study","volume":"124","author":"Bhatia","year":"2014","journal-title":"Blood"},{"key":"R6-5-20210213","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1016\/S0140-6736(96)91615-3","article-title":"Duration and intensity of maintenance chemotherapy in acute lymphoblastic leukaemia: overview of 42 trials involving 12000 randomised children.","volume":"347","author":"Childhood","year":"1996","journal-title":"Lancet"},{"key":"R7-5-20210213","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/jnci\/91.23.2001","article-title":"Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus","volume":"91","author":"Relling","year":"1999","journal-title":"J Natl Cancer Inst"},{"key":"R8-5-20210213","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/00008571-200208000-00003","article-title":"Azathioprine therapy and adverse drug reactions in patients with inflammatory bowel disease: impact of thiopurine S-methyltransferase polymorphism","volume":"12","author":"Schwab","year":"2002","journal-title":"Pharmacogenetics"},{"key":"R9-5-20210213","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/0140-6736(93)93168-Z","article-title":"Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient","volume":"341","author":"McLeod","year":"1993","journal-title":"Lancet"},{"key":"R10-5-20210213","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/ng.3060","article-title":"A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia","volume":"46","author":"Yang","year":"2014","journal-title":"Nat Genet"},{"key":"R11-5-20210213","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1200\/JCO.2014.59.4671","article-title":"Inherited NUDT15 variant is a genetic determinant of mercaptopurine intolerance in children with acute lymphoblastic leukemia","volume":"33","author":"Yang","year":"2015","journal-title":"J Clin Oncol"},{"key":"R12-5-20210213","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/ng.3508","article-title":"NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity","volume":"48","author":"Moriyama","year":"2016","journal-title":"Nat Genet"},{"key":"R13-5-20210213","doi-asserted-by":"crossref","first-page":"608","DOI":"10.7326\/0003-4819-126-8-199704150-00003","article-title":"Molecular diagnosis of thiopurine S-methyltransferase deficiency: genetic basis for azathioprine and mercaptopurine intolerance","volume":"126","author":"Yates","year":"1997","journal-title":"Ann Intern Med"},{"key":"R14-5-20210213","first-page":"694","article-title":"Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians","volume":"58","author":"Tai","year":"1996","journal-title":"Am J Hum Genet"},{"key":"R15-5-20210213","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/clpt.2013.4","article-title":"Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update","volume":"93","author":"Relling","year":"2013","journal-title":"Clin Pharmacol Ther"},{"key":"R16-5-20210213","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S1470-2045(17)30154-7","article-title":"DNA-thioguanine nucleotide concentration and relapse-free survival during maintenance therapy of childhood acute lymphoblastic leukaemia (NOPHO ALL2008): a prospective substudy of a phase 3 trial","volume":"18","author":"Nielsen","year":"2017","journal-title":"Lancet Oncol"},{"key":"R17-5-20210213","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/978-1-62703-357-2_20","article-title":"Thiopurine S-methyltransferase pharmacogenetics in childhood acute lymphoblastic leukemia","volume":"999","author":"Yang","year":"2013","journal-title":"Methods Mol Biol"},{"key":"R18-5-20210213","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jchromb.2011.11.032","article-title":"Liquid chromatography-tandem mass spectrometry quantification of 6-thioguanine in DNA using endogenous guanine as internal standard","volume":"881-882","author":"Jacobsen","year":"2012","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"R19-5-20210213","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00280-009-1184-5","article-title":"DNA incorporation of 6-thioguanine nucleotides during maintenance therapy of childhood acute lymphoblastic leukaemia and non-Hodgkin lymphoma","volume":"66","author":"Hedeland","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"R20-5-20210213","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00280-016-3151-2","article-title":"Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia","volume":"78","author":"Nielsen","year":"2016","journal-title":"Cancer Chemother Pharmacol"},{"key":"R21-5-20210213","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1182\/blood.V93.9.2817","article-title":"Prognostic importance of 6-mercaptopurine dose intensity in acute lymphoblastic leukemia","volume":"93","author":"Relling","year":"1999","journal-title":"Blood"},{"key":"R22-5-20210213","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/bjh.13518","article-title":"Susceptibility to 6-MP toxicity conferred by a NUDT15 variant in Japanese children with acute lymphoblastic leukaemia","volume":"171","author":"Tanaka","year":"2015","journal-title":"Br J Haematol"},{"key":"R23-5-20210213","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1038\/tpj.2015.75","article-title":"NUDT15 gene polymorphism related to mercaptopurine intolerance in Taiwan Chinese children with acute lymphoblastic leukemia","volume":"16","author":"Liang","year":"2016","journal-title":"Pharmacogenomics J"},{"key":"R24-5-20210213","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrc1800","article-title":"Acute lymphoblastic leukaemia: a model for the pharmacogenomics of cancer therapy","volume":"6","author":"Cheok","year":"2006","journal-title":"Nat Rev Cancer"}],"container-title":["Pharmacogenetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/FPC.0000000000000282","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T00:23:52Z","timestamp":1620951832000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01213011-201706000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":24,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1097\/fpc.0000000000000282","relation":{},"ISSN":["1744-6872"],"issn-type":[{"value":"1744-6872","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}