{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:39:29Z","timestamp":1787009969675,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,4]]},"abstract":"\n Objective:<\/jats:title>\n \n This study sought to evaluate the impacts of interactions between the\n alcohol dehydrogenase-1B<\/jats:italic>\n (rs1229984) genotype and the\n aldehyde dehydrogenase-2<\/jats:italic>\n (rs671) genotype on alcohol flushing, alcohol reeking on the day after drinking, and the age distribution in alcohol-dependent patients.\n <\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n \n The study subjects were 4107 Japanese alcohol-dependent men who underwent\n alcohol dehydrogenase-1B<\/jats:italic>\n and\n aldehyde dehydrogenase-2<\/jats:italic>\n genotyping: 4051 patients were asked about their current or former tendency to experience facial flushing after drinking a glass of beer, and 969 patients were asked about whether they had ever been told that they reeked of alcohol more than 12 hours after they had stopped drinking.\n <\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Current, former, and never flushing were reported in 3.5, 14.9, and 81.5%, respectively, of the subject, and alcohol reeking after more than 12 hours in 36.1% of the subjects. The fast-metabolizing\n ADH1B*2<\/jats:italic>\n (+) genotype (\n *1\/*2<\/jats:italic>\n or\n *2\/*2<\/jats:italic>\n ) and the inactive\n ALDH2*2<\/jats:italic>\n (+) genotype (\n *1\/*2<\/jats:italic>\n or\n *2\/*2<\/jats:italic>\n ) affected the multivariate odds ratios for current or former flushing [odds ratio, 95% confidence interval = 2.27 (1.79\u20132.86) and 23.0 (18.6\u201328.5), respectively, vs. *2(\u2212) genotype] and for alcohol reeking [0.39 (0.29\u20130.52) and 1.56 (1.09\u20132.25), respectively, vs. *2(\u2212) genotype]. An age-dependent decrease in the\n ADH1B*2<\/jats:italic>\n (\u2212) and\n ALDH2*2<\/jats:italic>\n (\u2212) combination from 32.3% in the 30\u201339-year age group to 12.5% in the 70\u201379-year age group and an age-dependent increase in the\n ADH1B*2<\/jats:italic>\n (+) and\n ALDH2*2<\/jats:italic>\n (\u2212) combination from 52.5% in the 30\u201339-year age group to 70.5% in the 70\u201379-year age group were observed (\n P<\/jats:italic>\n < 0.0001 for trend). The frequencies of the\n ADH1B*2<\/jats:italic>\n (\u2212) and\n ALDH2*2<\/jats:italic>\n (+) combination (4.7\u20136.2%) and the\n ADH1B*2<\/jats:italic>\n (+) and\n ALDH2*2<\/jats:italic>\n (+) combination (8.9\u201312.0%) did not change markedly with increasing age.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n \n Interactions between the\n alcohol dehydrogenase-1B<\/jats:italic>\n and\n aldehyde dehydrogenase-2<\/jats:italic>\n genotypes modified alcohol flushing, alcohol reeking on the day after drinking, and the age distribution. These findings support the protective roles of the\n ADH1B*2<\/jats:italic>\n (+) and\n ALDH2*2<\/jats:italic>\n (+) genotypes against the development of alcohol dependence.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/fpc.0000000000000395","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T14:49:59Z","timestamp":1582296599000},"page":"54-60","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":13,"title":["Impacts of interactions between ADH1B and ALDH2 genotypes on alcohol flushing, alcohol reeking on the day after drinking, and age distribution in Japanese alcohol-dependent men"],"prefix":"10.1097","volume":"30","author":[{"given":"Akira","family":"Yokoyama","sequence":"first","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, 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Kanagawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachio","family":"Matsushita","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Kanagawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susumu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Kanagawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuya","family":"Maruyama","sequence":"additional","affiliation":[{"name":"National Hospital Organization Kurihama Medical and Addiction Center, Yokosuka, Kanagawa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20251204","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1086\/521201","article-title":"Geographically separate increases in the frequency of the derived ADH1B*47his allele in eastern and 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