{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:49:58Z","timestamp":1748911798040},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The present prospective follow-up study aimed to evaluate the effects of <jats:italic toggle=\"yes\">KCNMB2<\/jats:italic> gene polymorphisms on ritodrine efficacy and adverse drug events (ADEs) in patients with preterm labor.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>A total of 163 preterm labor patients were included in this single-center study. Nine single nucleotide polymorphisms (SNPs) in the <jats:italic toggle=\"yes\">KCNMB2<\/jats:italic> gene (rs10936979, rs7624046, rs7429015, rs7625907, rs6443559, rs9839376, rs9637454, rs11918114, and rs1382045) were assessed. The primary endpoint was time to delivery, and the secondary endpoint was ritodrine-induced ADEs.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Patients with variant homozygotes of two SNPs (rs7624046 and rs9839376), which were in linkage disequilibrium, showed 2.06 [95% confidence interval (CI), 1.14\u20133.73] and 2.68 (95% CI, 1.16\u20136.20) times the hazard of time to delivery compared to wild-type allele carriers, respectively. Among demographic characteristics, gestational age at start of drug therapy and modified Bishop score were significant factors for time to delivery. Regarding safety outcomes, patients with variant homozygotes of rs7625907 had fewer ADEs compared to those with other genotypes (odds ratio, 0.32; 95% CI, 0.13\u20130.83).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This pharmacogenomic study suggests that ritodrine efficacy and ADEs are associated with <jats:italic toggle=\"yes\">KCNMB2<\/jats:italic> gene polymorphisms in patients with preterm labor.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/fpc.0000000000000404","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T01:37:22Z","timestamp":1588729042000},"page":"124-130","source":"Crossref","is-referenced-by-count":1,"title":["Effects of KCNMB2 gene polymorphisms on ritodrine therapy outcomes in women with preterm labor"],"prefix":"10.1097","volume":"30","author":[{"given":"Ha Young","family":"Yoon","sequence":"first","affiliation":[{"name":"College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Young","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong","family":"Yee","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Division of Life & Pharmaceutical Sciences, Ewha Womans University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han Sung","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jee Eun","family":"Chung","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Institute of Pharmaceutical 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