{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:35:54Z","timestamp":1788827754658,"version":"build-2803163510"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Metformin is the first-choice oral anti-hyperglycemic drug for type 2 diabetes mellitus (T2DM) patients. There are controversies about the association of SLC22A1 rs622342, which was not reported in the Chinese population, and ataxia-telangiectasia mutated (ATM) rs11212617 polymorphisms with metformin efficacy in T2DM. Our study was to investigate the effects of the two single nucleotide polymorphisms on the efficacy of metformin in T2DM of Han nationality in Chaoshan China. After enrollment, 82 newly diagnosed T2DM patients went on 2-month metformin monotherapy. According to BMI before treatment, the patients were divided into a normal weight group (\u226518.5 and &lt;25\u2009kg\/m<jats:sup>2<\/jats:sup>) and an overweight group (BMI\u2009\u2265\u200925 and &lt;30\u2009kg\/m<jats:sup>2<\/jats:sup>). <jats:italic toggle=\"yes\">T<\/jats:italic>-test, Pearson \u03c7<jats:sup>2<\/jats:sup> test, and regression analysis, which adjusted for age, BMI, sex, the dose of metformin, education, tea drink, smoking, and sweet, were used to evaluate the effects of rs622342 and rs11212617 on several variables, such as fasting plasma glucose (FPG). Compared with the AA or CC genotype, patients with AC genotype of rs622342 achieved greater reduction in \u039460<jats:sub>FPG<\/jats:sub> and \u0394(60\u201330)<jats:sub>FPG<\/jats:sub> (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.00820, 0.00089, respectively). For 11212617, the reduction in \u039430<jats:sub>FPG<\/jats:sub> and \u039460<jats:sub>FPG<\/jats:sub> was significantly different among patients with the AC genotype (<jats:italic toggle=\"yes\">P<\/jats:italic>\u2009=\u20090.00026, 0.00820, respectively). Our results indicated that common variants of SLC22A1 rs622342 and ATM rs11212617 were associated with the efficacy of metformin in T2DM of Han nationality in Chaoshan China.<\/jats:p>","DOI":"10.1097\/fpc.0000000000000454","type":"journal-article","created":{"date-parts":[[2021,9,21]],"date-time":"2021-09-21T04:38:48Z","timestamp":1632199128000},"page":"67-71","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Association of SLC22A1 rs622342 and ATM rs11212617 polymorphisms with metformin efficacy in patients with type 2 diabetes"],"prefix":"10.1097","volume":"32","author":[{"given":"Peixian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Endocrinology"},{"name":"Department of Infection Control"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Neurology, Meizhou People\u2019s Hospital, Meizhou, Guangdong Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Central Hospital of Shenzhen Guangming New District, Shenzhen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhike","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dafang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 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