{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T09:19:07Z","timestamp":1768555147997,"version":"3.49.0"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:p>Chemotherapy-induced nausea and vomiting (CINV) remains a common adverse effect for children with cancer. In children, chemotherapy emetogenicity and patient factors such as susceptibility to motion sickness and age group determine a patient\u2019s risk of CINV. Besides known risk factors, genetic factors may play a role in interindividual variation in the occurrence of CINV. We investigated the influence of candidate gene polymorphisms on the efficacy of antiemetics and on the background sensitivity to CINV in children. This prospective study included 100 children with cancer (median age 6.4 years, range 0.8\u201317.9) who received moderately to highly emetogenic chemotherapy. Participants registered nausea and vomiting episodes in a mobile app. Genotypes were determined by whole-genome sequencing (<jats:italic toggle=\"yes\">n<\/jats:italic> = 79) or Sanger sequencing (<jats:italic toggle=\"yes\">n<\/jats:italic> = 21) for 71 genetic polymorphisms involved in motion sickness and antiemetic pathways. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate associations between acute CINV and genotypes adjusting for susceptibility to motion sickness and age group. Rs3782025 in the 5-hydroxytryptamine type 3 (5-HT<jats:sub>3<\/jats:sub>) receptor gene (<jats:italic toggle=\"yes\">HTR3B<\/jats:italic>) [minor allele frequency (MAF): 0.48] affected response to 5-HT<jats:sub>3<\/jats:sub> receptor antagonists; acute CINV occurred in 76% of patients with GA\/AA genotypes and in 41% of patients with GG genotype (OR 5.59; 95% CI 1.74\u201317.9, dominant genetic model). Rs2975226 in the dopamine transporter gene <jats:italic toggle=\"yes\">(SLC6A3<\/jats:italic>) (MAF: 0.54) was associated with acute CINV (OR 5.79; 95% CI 1.09\u201330.67, recessive genetic model). Polymorphisms in <jats:italic toggle=\"yes\">HTR3B<\/jats:italic> and <jats:italic toggle=\"yes\">SLC6A3<\/jats:italic> may contribute to the variability in response to antiemetic prophylaxis for CINV in children.<\/jats:p>","DOI":"10.1097\/fpc.0000000000000460","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T01:01:24Z","timestamp":1636419684000},"page":"72-78","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":7,"title":["Background sensitivity to chemotherapy-induced nausea and vomiting and response to antiemetics in paediatric patients: a genetic association study"],"prefix":"10.1097","volume":"32","author":[{"given":"Astrid","family":"Eliasen","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg University Hospital"},{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatan","family":"Kornholt","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg University Hospital"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9","family":"Mathiasen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Wadt","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Stoltze","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet"},{"name":"Department of Clinical Genetics, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jesper","family":"Brok","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Rechnitzer","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjeld","family":"Schmiegelow","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Adolescent Medicine, Copenhagen University Hospital Rigshospitalet"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Dalhoff","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacology, Bispebjerg and Frederiksberg University Hospital"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Copenhagen"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2021,11,8]]},"reference":[{"key":"R1-20250808","first-page":"CD007786","article-title":"Antiemetic medication for prevention and treatment of chemotherapy-induced nausea and vomiting in childhood.","volume":"2","author":"Phillips","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"R2-20250808","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1200\/JCO.20.00134","article-title":"Factors associated 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