{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T19:13:04Z","timestamp":1793733184233,"version":"4.6.1"},"reference-count":89,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This umbrella review was conducted to summarize the association between HLA*1502 allele with antiepileptic induced Stevens\u2013Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Pubmed, Scopus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">EMBASE<\/jats:italic>\n                      were searched for eligible reviews in May 2023. Two authors independently screened titles and abstracts and assessed full-text reviews for eligibility. The quality of meta-analyses and case\u2013control studies was appraised with Assessing the Methodological Quality of Systematic Reviews 2 and Newcastle-Ottawa Scale, respectively. Narrative summaries of each antiepileptic drug were analyzed. Preestablished protocol was registered on the International Prospective Register of Systematic Reviews Registry(ID: CRD42023403957).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Included studies are systematic reviews, meta-analyses and case\u2013control studies evaluating the association of HLA-B*1502 allele with the following antiepileptics. Seven meta-analyses for carbamazepine, three meta-analyses for lamotrigine (LTG), three case\u2013control studies for oxcarbazepine, nine case\u2013control studies for phenytoin and four case\u2013control studies for phenobarbitone were included. The findings of this umbrella review suggest that there is a strong association between HLA-B-1502 with SJS\/TEN for carbamazepine and oxcarbazepine and a milder association for lamotrigine and phenytoin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, although HLA-B*1502 is less likely to be associated with phenytoin or lamotrigine-induced SJS\/TEN compared to carbamazepine-induced SJS\/TEN, it is a significant risk factor that if carefully screened, could potentially reduce the development of SJS\/TEN. In view of potential morbidity and mortality, HLA-B*1502 testing may be beneficial in patients who are initiating lamotrigine\/phenytoin therapy. However, further studies are required to examine the association of other alleles with the development of SJS\/TEN and to explore the possibility of genome-wide association studies before initiation of treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/fpc.0000000000000531","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T15:00:09Z","timestamp":1711378809000},"page":"154-165","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Unraveling the genetic link: an umbrella review on HLA-B*15:02 and antiepileptic drug-induced Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis"],"prefix":"10.1097","volume":"34","author":[{"given":"Kar Mun","family":"Tham","sequence":"first","affiliation":[{"name":"Department of Pain Medicine, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacklyn Jia Lin","family":"Yek","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine, Singapore General Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher Wei Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pain Medicine, Singapore General Hospital, Singapore"},{"name":"Anesthesiology and Perioperative Sciences Academic Clinical Program, Duke-NUS Graduate Medical School"},{"name":"Napier Pain Specialists, Gleneagles Hospital, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,22]]},"reference":[{"key":"R1-20250808","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.seizure.2020.10.018","article-title":"Current role of carbamazepine and oxcarbazepine in the management of epilepsy.","volume":"83","author":"Beydoun","year":"2020","journal-title":"Seizure"},{"key":"R2-20250808","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1055\/s-2007-979609","article-title":"Carbamazepine clinical pharmacology: a review.","volume":"28","author":"Albani","year":"1995","journal-title":"Pharmacopsychiatry"},{"key":"R3-20250808","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.autrev.2008.06.004","article-title":"Stevens\u2013Johnson syndrome and toxic epidermal necrolysis.","volume":"7","author":"Borchers","year":"2008","journal-title":"Autoimmun Rev"},{"key":"R4-20250808","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome.","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"R8-20250808","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/cpt.1004","article-title":"Clinical Pharmacogenetics Implementation Consortium Guideline for HLA Genotype and Use of Carbamazepine and Oxcarbazepine: 2017 Update.","volume":"103","author":"Phillips","year":"2018","journal-title":"Clin Pharmacol Ther"},{"key":"R9-20250808","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jdermsci.2013.10.003","article-title":"Genotype-phenotype association between HLA and carbamazepine-induced hypersensitivity reactions: strength and clinical correlations.","volume":"73","author":"Hsiao","year":"2013","journal-title":"J Dermatol Sci"},{"key":"R10-20250808","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/clpt.2014.159","article-title":"Clinical pharmacogenetics implementation consortium guidelines for CYP2C9 and HLA-B genotypes and phenytoin dosing.","volume":"96","author":"Caudle","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"R11-20250808","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.recesp.2021.06.016","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews.","volume":"74","author":"Page","year":"2021","journal-title":"Revista espanola de cardiologia (English ed.)"},{"key":"R12-20250808","doi-asserted-by":"crossref","first-page":"j4008","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both.","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"R13-20250808","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/jebm.12427","article-title":"The ROBINS-I and the NOS had similar reliability but differed in applicability: a random sampling observational studies of systematic reviews\/meta-analysis.","volume":"14","author":"Zhang","year":"2021","journal-title":"J. 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