{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:55:34Z","timestamp":1790546134208,"version":"4.1.0"},"reference-count":9,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:p>This short communication serves as an update to previously published pilot study results on bronchodilator response (BDR) in children with asthma. We expanded our cohort from 54 to 165 pediatric patients seeking emergency department care for an asthma exacerbation. We obtained measured BDR before and after albuterol administration using the Pediatric Asthma Severity Score and collected genomic DNA. Based on a literature review, we analyzed whether 21 candidate single-nucleotide polymorphisms (SNPs) were associated with BDR. Among the three SNPs initially reported in our pilot study as significantly associated with BDR (rs912142, rs7081864, and rs7903366), we confirmed that rs7081864 was still significantly associated with suboptimal BDR (odds ratio, 0.47; confidence interval, 0.24\u20130.92). If externally validated in broader studies, simple outpatient testing for that SNP variant could help guide pharmacologic therapy for acute asthma symptoms.<\/jats:p>","DOI":"10.1097\/fpc.0000000000000557","type":"journal-article","created":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T14:06:55Z","timestamp":1734530815000},"page":"116-118","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Updated analysis of the pharmacogenomics of pediatric bronchodilator response"],"prefix":"10.1097","volume":"35","author":[{"given":"Jennifer","family":"Brailsford","sequence":"first","affiliation":[{"name":"Center for Data Solutions"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Labilloy","sequence":"additional","affiliation":[{"name":"Center for Data Solutions"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolan","family":"Menze","sequence":"additional","affiliation":[{"name":"Division of Research, Department of Emergency Medicine, University of Florida College of Medicine \u2013 Jacksonville, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Henson","sequence":"additional","affiliation":[{"name":"Division of Research, Department of Emergency Medicine, University of Florida College of Medicine \u2013 Jacksonville, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Fishe","sequence":"additional","affiliation":[{"name":"Center for Data Solutions"},{"name":"Division of Research, Department of Emergency Medicine, University of Florida College of Medicine \u2013 Jacksonville, Jacksonville, Florida, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"R4-20250227","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1080\/02770903.2019.1579343","article-title":"Differentiating non-responders from responders in children with moderate and severe asthma exacerbations.","volume":"57","author":"Sneller","year":"2020","journal-title":"J Asthma"},{"key":"R5-20250227","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s11882-021-01023-w","article-title":"Pharmacogenetics of bronchodilator response: future directions.","volume":"21","author":"Sordillo","year":"2021","journal-title":"Curr Allergy Asthma Rep"},{"key":"R6-20250227","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/FPC.0000000000000434","article-title":"Single nucleotide polymorphisms (SNPs) in PRKG1 & SPATA13-AS1 are associated with bronchodilator response: a pilot study during acute asthma exacerbations in African American children.","volume":"31","author":"Fishe","year":"2021","journal-title":"Pharmacogenet Genomics"},{"key":"R7-20250227","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1197\/j.aem.2003.07.015","article-title":"Performance of a novel clinical score, the Pediatric Asthma Severity Score (PASS), in the evaluation of acute asthma.","volume":"11","author":"Gorelick","year":"2004","journal-title":"Acad Emerg Med"},{"key":"R9-20250227","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41397-018-0042-4","article-title":"A genome-wide association and admixture mapping study of bronchodilator drug response in African Americans with asthma.","volume":"19","author":"Spear","year":"2019","journal-title":"Pharmacogenomics J"},{"key":"R10-20250227","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1080\/02770903.2024.2303763","article-title":"Association between PRKG1 gene and gene-environment interactions with pediatric asthma.","volume":"61","author":"Liu","year":"2024","journal-title":"J Asthma"},{"key":"R11-20250227","doi-asserted-by":"crossref","first-page":"8884229","DOI":"10.1155\/2021\/8884229","article-title":"Next generation exome sequencing of pediatric asthma identifies rare and novel variants in candidate genes.","volume":"2021","author":"Bogari","year":"2021","journal-title":"Dis Markers"},{"key":"R12-20250227","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/cpt.2526","article-title":"Clinical pharmacogenetics implementation consortium guideline for cyp2c19 genotype and clopidogrel therapy: 2022 update.","volume":"112","author":"Lee","year":"2022","journal-title":"Clin Pharmacol Ther"},{"key":"R13-20250227","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.jaip.2021.10.011","article-title":"A practical guide to implementing SMART in asthma management.","volume":"10","author":"Reddel","year":"2022","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Pharmacogenetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/FPC.0000000000000557","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T11:01:50Z","timestamp":1740654110000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/FPC.0000000000000557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,19]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/fpc.0000000000000557","relation":{},"ISSN":["1744-6872","1744-6880"],"issn-type":[{"value":"1744-6872","type":"print"},{"value":"1744-6880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,19]]}}}