{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:48:32Z","timestamp":1784832512258,"version":"3.55.0"},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>The research question is as follows: Are estrogen and progesterone receptor genotypes associated with thin endometrium? We performed a prospective cohort study of 129 patients who underwent preimplantation genetic testing for aneuploidies. These patients were categorized according to endometrial thickness: &gt;7\u2005mm control group (<jats:italic toggle=\"yes\">n<\/jats:italic>\u2005=\u200594) and \u22647\u2005mm study group (<jats:italic toggle=\"yes\">n<\/jats:italic>\u2005=\u200535). Polymorphisms in the genes <jats:italic toggle=\"yes\">ESR1<\/jats:italic> (rs9340799 and rs3138774), <jats:italic toggle=\"yes\">ESR2<\/jats:italic> (rs1256049 and rs4986938), and <jats:italic toggle=\"yes\">PGR<\/jats:italic> (rs1042838) were analyzed. Regarding genotype distribution, the GA\/AA genotype frequency for rs4986938-<jats:italic toggle=\"yes\">ESR2<\/jats:italic> was higher in the thin endometrium group (80% in the study group vs. 50% in the control group; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u20050.002), as well as the GG genotype of <jats:italic toggle=\"yes\">PGR<\/jats:italic> (8.6% in the study group vs. 0% in the control group; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u20050.002). No differences were observed for the remaining genotypes. In terms of clinical data, the pregnancy rate after euploid embryo transfer was lower in patients with the AA genotype for rs4986938-<jats:italic toggle=\"yes\">ESR2<\/jats:italic> (18.2% AA vs. 40.8% GA vs. 44.0% GG; <jats:italic toggle=\"yes\">P<\/jats:italic>\u2005=\u20050.039). Finally, a predictive pregnancy model was developed using clinical data and <jats:italic toggle=\"yes\">ESR2<\/jats:italic> and <jats:italic toggle=\"yes\">PGR<\/jats:italic> genotypes, with an area under the curve of 0.76, sensitivity of 64%, and specificity of 76%. The genetic variants rs4986938 in the <jats:italic toggle=\"yes\">ESR2<\/jats:italic> gene and rs1042838 in the <jats:italic toggle=\"yes\">PGR<\/jats:italic> gene seem to correlate with idiopathic thin endometrium. In addition, the rs4986938 polymorphism in the <jats:italic toggle=\"yes\">ESR2<\/jats:italic> gene is associated with pregnancy rate. Finally, a predictive model combining clinical data and patient genetic profiles has been proposed to predict clinical pregnancy outcomes.<\/jats:p>","DOI":"10.1097\/fpc.0000000000000560","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T16:00:38Z","timestamp":1738166438000},"page":"136-139","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Association of estrogen and progesterone receptor polymorphisms with idiopathic thin endometrium"],"prefix":"10.1097","volume":"35","author":[{"given":"Bel\u00e9n","family":"Lledo","sequence":"first","affiliation":[{"name":"Molecular Biology, Instituto Bernabeu Biotech"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Hortal","sequence":"additional","affiliation":[{"name":"Molecular Biology, Instituto Bernabeu Biotech"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, Instituto Bernabeu of Fertility and Gynaecology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Molecular Biology, Instituto Bernabeu Biotech"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Morales","sequence":"additional","affiliation":[{"name":"Molecular Biology, Instituto Bernabeu Biotech"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bernabeu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine, Instituto Bernabeu of Fertility and Gynaecology"},{"name":"C\u00e1tedra de Medicina Comunitaria y Salud Reproductiva, Miguel Hern\u00e1ndez University, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,1,27]]},"reference":[{"key":"R1-20250430","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/GCO.0000000000000863","article-title":"Treatment options for endometrial hypoproliferation.","volume":"35","author":"Cakiroglu","year":"2023","journal-title":"Curr Opin Obstet Gynecol"},{"key":"R2-20250430","doi-asserted-by":"crossref","first-page":"hoad028","DOI":"10.1093\/hropen\/hoad028","article-title":"The thicker the endometrium, the better the neonatal outcomes?","volume":"2023","author":"Wu","year":"2023","journal-title":"Hum Reprod Open"},{"key":"R3-20250430","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.ejogrb.2024.01.008","article-title":"Association of estrogen receptor and progesterone receptor genetic polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis.","volume":"296","author":"Huang","year":"2024","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R4-20250430","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1159\/000334174","article-title":"A study on the estrogen receptor \u03b1 gene polymorphism and its expression in thin endometrium of unknown etiology.","volume":"74","author":"Yuan","year":"2012","journal-title":"Gynecol Obstet Invest"},{"key":"R5-20250430","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.4238\/2013.November.26.7","article-title":"Association of the estrogen receptor-\u03b2 gene RsaI and AluI polymorphisms with human idiopathic thin endometrium.","volume":"12","author":"Le","year":"2013","journal-title":"Genet Mol Res"},{"key":"R6-20250430","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/1471-2156-10-55","article-title":"Effects of two common polymorphisms in the 3\u2019 untranslated regions of estrogen receptor beta on mRNA stability and translatability.","volume":"10","author":"Putnik","year":"2009","journal-title":"BMC Genet"},{"key":"R7-20250430","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/jme.1.02170","article-title":"The PROGINS polymorphism of the human progesterone receptor diminishes the response to progesterone.","volume":"38","author":"Romano","year":"2007","journal-title":"J Mol Endocrinol"},{"key":"R8-20250430","doi-asserted-by":"crossref","first-page":"146804","DOI":"10.1016\/j.gene.2022.146804","article-title":"Role of polymorphisms on the recurrent pregnancy loss: a systematic review, meta-analysis and bioinformatic analysis.","volume":"844","author":"Jalilvand","year":"2022","journal-title":"Gene"}],"container-title":["Pharmacogenetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/FPC.0000000000000560","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T11:00:12Z","timestamp":1746010812000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/FPC.0000000000000560"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,27]]},"references-count":8,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1097\/fpc.0000000000000560","relation":{},"ISSN":["1744-6872","1744-6880"],"issn-type":[{"value":"1744-6872","type":"print"},{"value":"1744-6880","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,27]]}}}