{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T02:59:52Z","timestamp":1771037992818,"version":"3.50.1"},"reference-count":29,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1097\/fpc.0b013e32832af5a3","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T22:46:46Z","timestamp":1242946006000},"page":"422-428","source":"Crossref","is-referenced-by-count":96,"title":["The effects of vitamin supplementation and MTHFR (C677T) genotype on homocysteine-lowering and migraine disability"],"prefix":"10.1097","volume":"19","author":[{"given":"Rod","family":"Lea","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie","family":"Colson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Quinlan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Macmillan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lyn","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"1","key":"R1-5-20210212","first-page":"1","article-title":"The International Classification of Headache Disorders (2nd edition)","volume":"24","year":"2004","journal-title":"Cephalalgia"},{"key":"R2-5-20210212","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0733-8619(05)70293-0","article-title":"Current concepts of the pathophysiology of migraine","volume":"15","author":"Goadsby","year":"1997","journal-title":"Neurol Clin"},{"key":"R3-5-20210212","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/S0140-6736(97)11370-8","article-title":"Migraine","volume":"351","author":"Ferrari","year":"1998","journal-title":"Lancet"},{"key":"R4-5-20210212","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1212\/WNL.56.10.1273","article-title":"Association between migraine and endothelin type A receptor (ETA -231 A\/G) gene polymorphism","volume":"56","author":"Tzourio","year":"2001","journal-title":"Neurology"},{"key":"R5-5-20210212","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1172\/JCI108520","article-title":"Homocysteine-induced arteriosclerosis: the role of endothelial cell injury and platelet response in its genesis","volume":"58","author":"Harker","year":"1976","journal-title":"J Clin Invest"},{"key":"R6-5-20210212","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0049-3848(80)90175-9","article-title":"Homocysteine-induced endothelial cell injury in vitro: a model for the study of vascular injury","volume":"18","author":"Wall","year":"1980","journal-title":"Thromb Res"},{"key":"R7-5-20210212","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1172\/JCI116187","article-title":"Adverse vascular effects of homocysteine are modulated by endothelium-derived relaxing factor and related oxides of nitrogen","volume":"91","author":"Stamler","year":"1993","journal-title":"J Clin Invest"},{"key":"R8-5-20210212","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1161\/01.ATV.14.5.653","article-title":"Is NO an endogenous antiatherogenic molecule?","volume":"14","author":"Cooke","year":"1994","journal-title":"Arterioscler Thromb"},{"key":"R9-5-20210212","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI118771","article-title":"Vascular dysfunction in monkeys with diet-induced hyperhomocyst(e)inemia","volume":"98","author":"Lentz","year":"1996","journal-title":"J Clin Invest"},{"key":"R10-5-20210212","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1046\/j.1526-4610.2001.01143.x","article-title":"Is blood homocysteine elevated in migraine","volume":"41","author":"Hering-Hanit","year":"2001","journal-title":"Headache"},{"key":"R11-5-20210212","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1113\/jphysiol.1987.sp016658","article-title":"Heterotopic activation of A delta and C fibres triggers inhibition of trigeminal and spinal convergent neurones in the rat","volume":"389","author":"Bouassira","year":"1987","journal-title":"J Physiol"},{"key":"R12-5-20210212","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1093\/brain\/120.12.2171","article-title":"Microiontophoretic application of serotonin (5HT)1B\/1D agonists inhibits trigeminal cell firing in the cat","volume":"120","author":"Storer","year":"1997","journal-title":"Brain"},{"key":"R13-5-20210212","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"R14-5-20210212","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1136\/bmj.307.6899.289","article-title":"Migraine and risk of ischaemic stroke: a case-control study","volume":"307","author":"Tzourio","year":"1993","journal-title":"BMJ"},{"key":"R15-5-20210212","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1001\/archneur.1997.00550160012009","article-title":"Association between migraine and stroke in a large-scale epidemiological study of the United States","volume":"54","author":"Merikangas","year":"1997","journal-title":"Arch Neurol"},{"key":"R16-5-20210212","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1111\/j.1468-2982.2007.01405.x","article-title":"Migraine and ischaemic vascular events","volume":"27","author":"Kurth","year":"2007","journal-title":"Cephalalgia"},{"key":"R17-5-20210212","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ana.20755","article-title":"Migraine and MTHFR C677\u2009T genotype in a population-based sample","volume":"59","author":"Scher","year":"2006","journal-title":"Ann Neurol"},{"issue":"1","key":"R18-5-20210212","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1046\/j.1526-4610.2001.01154-3.x","article-title":"Shared mechanisms and comorbidities in neurologic and psychiatric disorders","volume":"41","author":"Silberstein","year":"2001","journal-title":"Headache"},{"key":"R19-5-20210212","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/S0140-6736(07)60854-X","article-title":"Efficacy of folic acid supplementation in stroke prevention: a meta-analysis","volume":"369","author":"Wang","year":"2007","journal-title":"Lancet"},{"key":"R20-5-20210212","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/ng0595-111","article-title":"A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase","volume":"10","author":"Frosst","year":"1995","journal-title":"Nat Genet"},{"key":"R21-5-20210212","first-page":"1199","article-title":"Association of the C677T polymorphism in the MTHFR gene with migraine: a meta-analysis","volume":"27","author":"Rubino","year":"2007","journal-title":"Cephalalgia"},{"key":"R22-5-20210212","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1046\/j.1468-2982.2000.00117.x","article-title":"Guidelines for controlled trials of drugs in migraine: 2nd edition","volume":"20","author":"Tfelt-Hansen","year":"2000","journal-title":"Cephalalgia"},{"key":"R23-5-20210212","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1212\/WNL.53.5.988","article-title":"An international study to assess reliability of the Migraine Disability Assessment (MIDAS) score","volume":"53","author":"Stewart WF, Lipton","year":"1999","journal-title":"Neurology"},{"key":"R24-5-20210212","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1046\/j.1468-2982.1999.019002107.x","article-title":"Reliability of the migraine disability assessment score in a population-based sample of headache sufferers","volume":"19","author":"Stewart WF, Lipton","year":"1999","journal-title":"Cephalalgia"},{"key":"R25-5-20210212","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1741-7015-2-3","article-title":"The methylenetetrahydrofolate reductase gene variant C677T influences susceptibility to migraine with aura","volume":"2","author":"Lea","year":"2004","journal-title":"BMC Med"},{"key":"R26-5-20210212","doi-asserted-by":"crossref","first-page":"331","DOI":"10.7326\/0003-4819-131-5-199909070-00003","article-title":"Serum total homocysteine concentrations in the third National Health and Nutrition Examination Survey (1991\u20131994): population reference ranges and contribution of vitamin status to high serum concentrations","volume":"131","author":"Selhub","year":"1999","journal-title":"Ann Intern Med"},{"key":"R27-5-20210212","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1526-4610.2007.00932.x","article-title":"Efficacy of folic acid in children with migraine, hyperhomocysteinemia and MTHFR polymorphisms","volume":"47","author":"Di Rosa","year":"2007","journal-title":"Headache"},{"key":"R28-5-20210212","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1161\/01.STR.0000199845.27512.84","article-title":"Methylenetetrahydrofolate reductase polymorphisms and homocysteine-lowering effect of vitamin therapy in Singaporean stroke patients","volume":"37","author":"Ho","year":"2006","journal-title":"Stroke"},{"key":"R29-5-20210212","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1526-4610.1969.hed0804167.x","article-title":"The use of folic acid in vascular headache of the migraine type","volume":"8","author":"Kopjas","year":"1969","journal-title":"Headache"}],"container-title":["Pharmacogenetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/01213011-200906000-00005","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T01:49:38Z","timestamp":1618364978000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01213011-200906000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":29,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/fpc.0b013e32832af5a3","relation":{},"ISSN":["1744-6872"],"issn-type":[{"value":"1744-6872","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}