{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:57:31Z","timestamp":1790978251356,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1097\/fpc.0b013e32833df033","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T08:31:57Z","timestamp":1282293117000},"page":"605-610","source":"Crossref","is-referenced-by-count":28,"title":["Genetic polymorphism of catechol-O-methyltransferase and cytochrome P450c17 in preeclampsia"],"prefix":"10.1097","volume":"20","author":[{"given":"Ji Hyae","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Yeon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ho Won","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung Yeol","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Won","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyug","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Mee","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210213","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0140-6736(05)17987-2","article-title":"Pre-eclampsia","volume":"365","author":"Sibai","year":"2005","journal-title":"Lancet"},{"key":"R2-4-20210213","first-page":"608","article-title":"Actions of placental and fetal adrenal steroid hormones in primate pregnancy","volume":"16","author":"Pepe","year":"1995","journal-title":"Endocr Rev"},{"key":"R3-4-20210213","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0008-6363(02)00508-4","article-title":"Intrauterine undernutrition: expression and activity of the endothelial nitric oxide synthase in male and female adult offspring","volume":"56","author":"Franco Mdo","year":"2002","journal-title":"Cardiovasc Res"},{"key":"R4-4-20210213","first-page":"155","article-title":"Advances in the epidemiology of gestational trophoblastic disease","volume":"39","author":"Palmer","year":"1994","journal-title":"J Reprod Med"},{"key":"R5-4-20210213","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/0039-128X(93)90102-S","article-title":"The role of reproductive hormones in vascular disease and hypertension","volume":"58","author":"Radwanska","year":"1993","journal-title":"Steroids"},{"issue":"2","key":"R6-4-20210213","first-page":"B19","article-title":"Etiology and pathogenesis of gestational diabetes","volume":"21","author":"K\u00fchl","year":"1998","journal-title":"Diabetes Care"},{"key":"R7-4-20210213","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.HYP.0000200042.64517.19","article-title":"Time course of maternal plasma volume and hormonal changes in women with preeclampsia or fetal growth restriction","volume":"47","author":"Salas","year":"2006","journal-title":"Hypertension"},{"key":"R8-4-20210213","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0002-9378(99)70150-X","article-title":"Androgen in preeclampsia","volume":"180","author":"Acromite","year":"1999","journal-title":"Am J Obstet Gynecol"},{"key":"R9-4-20210213","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.0001-6349.2005.00493.x","article-title":"Early second-trimester maternal hyperandrogenemia and subsequent preeclampsia: a prospective study","volume":"84","author":"Carlsen","year":"2005","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R10-4-20210213","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/0888-7543(92)90316-K","article-title":"Chromosomal mapping of the human catechol-O-methyltransferase gene to 22q11.1\u201322q11.2","volume":"12","author":"Grossman","year":"1992","journal-title":"Genomics"},{"key":"R11-4-20210213","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.758679","article-title":"Catechol-O-methyltransferase: thermolabile enzyme in erythrocytes of subjects homozygous for allele for low activity","volume":"203","author":"Scanlon","year":"1979","journal-title":"Science"},{"key":"R12-4-20210213","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1086\/425589","article-title":"Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain","volume":"75","author":"Chen","year":"2004","journal-title":"Am J Hum Genet"},{"key":"R13-4-20210213","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature06951","article-title":"Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia","volume":"453","author":"Kanasaki","year":"2008","journal-title":"Nature"},{"key":"R14-4-20210213","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1089\/dna.1987.6.439","article-title":"Cloning and sequence of the human gene for P450c17 (steroid 17 alpha-hydroxylase\/17,20 lyase): similarity with the gene for P450c21","volume":"6","author":"Picado-Leonard","year":"1987","journal-title":"DNA"},{"key":"R15-4-20210213","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/hmg\/3.10.1873","article-title":"Polycystic ovaries and premature male pattern baldness are associated with one allele of the steroid metabolism gene CYP17","volume":"3","author":"Carey","year":"1994","journal-title":"Hum Mol Genet"},{"key":"R16-4-20210213","first-page":"585","article-title":"Cytochrome P450c17a gene (CYP17) polymorphism is associated with serum estrogen and progesterone concentrations","volume":"58","author":"Feilgelson","year":"1998","journal-title":"Cancer Res"},{"key":"R17-4-20210213","first-page":"1015","article-title":"The relationship between a polymorphism in CYP17 with plasma hormone levels and breast cancer","volume":"59","author":"Haiman","year":"1999","journal-title":"Cancer Res"},{"key":"R18-4-20210213","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1097\/01.fpc.0000230116.49452.c0","article-title":"Functional maternal catechol-O-methyltransferase polymorphism and fetal growth restriction","volume":"16","author":"Sata","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"R19-4-20210213","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1097\/AOG.0b013e3181719b7a","article-title":"Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors","volume":"111","author":"Lim","year":"2008","journal-title":"Obstet Gynecol"},{"key":"R20-4-20210213","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2353\/ajpath.2010.090513","article-title":"Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions","volume":"176","author":"Lee","year":"2010","journal-title":"Am J Pathol"},{"key":"R21-4-20210213","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/molehr\/gah005","article-title":"A polymorphism in the CYP17 gene and intrauterine fetal growth restriction","volume":"10","author":"Yamada","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"R22-4-20210213","first-page":"2825","article-title":"CYP17 and breast cancer risk: the polymorphism in the 5\u2032 flanking area of the gene does not influence binding to Sp-1","volume":"59","author":"Nedelcheva Kristensen","year":"1999","journal-title":"Cancer Res"},{"key":"R23-4-20210213","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/ije\/dyg094","article-title":"Maternal serum oestrogen and androgen concentrations in preeclamptic and uncomplicated pregnancies","volume":"32","author":"Troisi","year":"2003","journal-title":"Int J Epidemiol"},{"key":"R24-4-20210213","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.0001-6349.2004.00276.x","article-title":"The relationship between plasma levels of leptin and androgen in healthy and preeclamptic pregnant women","volume":"83","author":"Atamer","year":"2004","journal-title":"Acta Obstet Gynecol Scand"},{"key":"R25-4-20210213","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1067\/mob.2000.103890","article-title":"Can antenatal clinical and biochemical markers predict the development of severe preeclampsia?","volume":"182","author":"Stamilio","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"R26-4-20210213","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/sj.bjc.6603921","article-title":"Preeclampsia and maternal breast cancer risk by offspring gender: do elevated androgen concentrations play a role?","volume":"97","author":"Troisi","year":"2007","journal-title":"Br J Cancer"},{"key":"R27-4-20210213","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.ejogrb.2005.07.007","article-title":"Androgen levels in the third trimester of pregnancy in patients with preeclampsia","volume":"126","author":"Salamalekis","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"}],"container-title":["Pharmacogenetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01213011-201010000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:35:21Z","timestamp":1786041321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01213011-201010000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":27,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/fpc.0b013e32833df033","relation":{},"ISSN":["1744-6872"],"issn-type":[{"value":"1744-6872","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}