{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,16]],"date-time":"2024-09-16T18:35:22Z","timestamp":1726511722378},"reference-count":18,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2]]},"abstract":"\n Background:<\/jats:title>\n The empiric antimicrobial therapy for bacteremia of long-term hemodialysis (HD) outpatients is currently based on the combination of vancomycin and gentamicin because of the high frequency of isolated Staphylococcus<\/jats:italic> species. The vancomycin trough level range from 15 to 20 mcg\/mL is expected for therapeutic success against methicillin-resistant Staphylococcus aureus<\/jats:italic> with vancomycin minimum inhibitory concentration (MIC) \u22651.0 mcg\/mL. Despite the availability of clinical practice guidelines for vancomycin therapeutic drug monitoring, these target serum concentrations are not reached in many patients.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n In this study, the authors investigated the vancomycin trough levels in 20 HD patients with S. aureus<\/jats:italic> bacteremia and the antimicrobial susceptibility pattern of 45 S. aureus<\/jats:italic> strains isolated from 45 HD patients. The vancomycin serum concentration was determined by chemiluminescent assay. The MIC was determined by broth microdilution method.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n None of the HD patients included in this study had vancomycin trough concentrations within the therapeutic range. Also, the vancomycin MIC for most methicillin-sensitive S. aureus<\/jats:italic> isolated from bacteremia was \u22651.0 mcg\/mL.<\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The therapeutic range of vancomycin was not achieved, and vancomycin MIC was surprisingly high in methicillin-sensitive S. aureus<\/jats:italic>.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/ftd.0000000000000581","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T07:20:08Z","timestamp":1543994408000},"page":"38-43","source":"Crossref","is-referenced-by-count":5,"title":["Low Serum Trough Concentrations and High Vancomycin Minimum Inhibitory Concentration in Methicillin-Sensitive Staphylococcus aureus From Hemodialysis Patients in Brazil"],"prefix":"10.1097","volume":"41","author":[{"given":"Michel Penedo da","family":"Vit\u00f3ria","sequence":"first","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Gomes de Sousa","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Capixaba do Rim; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauro Monteiro","family":"Vasconcellos Filho","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Capixaba do Rim; and"},{"name":"Department of Clinical Medicine, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES), Vit\u00f3ria, Esp\u00edrito Santo, Brazil."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9ssica de C\u00e1ssia Teixeira","family":"Birro","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maralisi Coutinho","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Abou Mourad","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Pinto","family":"Schuenck","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Ferreira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00eania Val\u00e9ria dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Pathology, Health Sciences Center, Federal University of Esp\u00edrito Santo (UFES);"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-20230814","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/kisup.2015.2","article-title":"United States renal data system public health surveillance of chronic kidney disease and end-stage renal disease","volume":"5","author":"Collins","year":"2015","journal-title":"Kidney Int Suppl (2011)."},{"key":"R3-20230814","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/ki.2010.35","article-title":"Recent changes in vancomycin use in renal failure","volume":"77","author":"Vandecasteele","year":"2010","journal-title":"Kidney Int."},{"key":"R4-20230814","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1525-139X.2007.00333.x","article-title":"Vancomycin use in patients requiring hemodialysis: a literature review","volume":"21","author":"Pallotta","year":"2008","journal-title":"Semin Dial."},{"key":"R5-20230814","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/ajhp\/60.15.1564","article-title":"Vancomycin administration during dialysis with low-flux polysulfone membranes: traditional versus a supplemental dosage regimen","volume":"60","author":"Stamatakis","year":"2003","journal-title":"Am J Health Syst Pharm."},{"key":"R6-20230814","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.ackd.2006.04.005","article-title":"Optimizing antimicrobial therapy for gram-positive bloodstream infections in patients on hemodialysis","volume":"13","author":"Pai","year":"2006","journal-title":"Adv Chronic Kidney Dis."},{"key":"R7-20230814","doi-asserted-by":"crossref","first-page":"e0146224","DOI":"10.1371\/journal.pone.0146224","article-title":"Association between the AUC0-24\/MIC ratio of vancomycin and its clinical effectiveness: a systematic review and meta-analysis. 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