{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T04:12:50Z","timestamp":1749010370353,"version":"3.41.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>The severe acute respiratory syndrome coronavirus 2 outbreak has been classified as a pandemic. Because many coronaviruses are heat sensitive, heat inactivation of patient samples at 56\u00b0C before testing reduces the risk of transmission. The aim of this study is to assess the impact of heat inactivation of patient blood samples on plasma concentrations of 5 second-generation antipsychotics and their metabolites.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>Blood samples were collected during routine clinical therapeutic drug monitoring examination between April 3, 2021, and April 19, 2021. Samples were divided into 2 groups: group A, noninactivated raw sample, and group B, inactivated samples. Inactivation was performed by a 30-minute incubation at 56\u00b0C. The levels of the 5 drugs and their metabolites before and after sample heat inactivation were measured using liquid chromatography-tandem mass spectrometry and compared. Furthermore, correlation and Bland\u2013Altman analyses were conducted.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>No statistically significant difference was observed between the levels of the 5 drugs and their metabolites (ie, risperidone, 9-OH-risperidone, aripiprazole, dehydroaripiprazole, olanzapine, quetiapine, norquetiapine, clozapine, and norclozapine) in the noninactivated group A and the inactivated group B (<jats:italic toggle=\"yes\">P<\/jats:italic> &gt; 0.05). Each drug's concentration values in inactivated and noninactivated treatments correlated (Spearman <jats:italic toggle=\"yes\">r<\/jats:italic>\n                                 <jats:sub>s<\/jats:sub> &gt; 0.98; <jats:italic toggle=\"yes\">P &lt;<\/jats:italic> 0.001). The results of the noninactivated treatment methods and samples alone showed good consistency via Bland\u2013Altman analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>Blood sample heat inactivation had no significant effect on the therapeutic drug monitoring of 5 second-generation antipsychotics and their metabolites. This inactivated treatment method should be recommended to effectively protect laboratory staff from virus contamination.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/ftd.0000000000000989","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T17:05:34Z","timestamp":1651165534000},"page":"701-706","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Heat Inactivation of Blood Samples on Therapeutic Drug Monitoring of 5 Second-Generation Antipsychotics and Their Metabolites"],"prefix":"10.1097","volume":"44","author":[{"given":"Jing","family":"Ding","sequence":"first","affiliation":[{"name":"Pharmacy Laboratory, Xi'an Mental Health Center, Xi'an, P.R. China; and"},{"name":"Xi'an Key Laboratory of Pharmacy (Mental Health), Xi'an, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Pharmacy Laboratory, Xi'an Mental Health Center, Xi'an, P.R. China; and"},{"name":"Xi'an Key Laboratory of Pharmacy (Mental Health), Xi'an, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacy Laboratory, Xi'an Mental Health Center, Xi'an, P.R. China; and"},{"name":"Xi'an Key Laboratory of Pharmacy (Mental Health), Xi'an, P.R. China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Pharmacy Laboratory, Xi'an Mental Health Center, Xi'an, P.R. China; and"},{"name":"Xi'an Key Laboratory of Pharmacy (Mental Health), Xi'an, P.R. 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