{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:39Z","timestamp":1786119459819,"version":"build-2736575974"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1097\/ftd.0b013e3181db99a8","type":"journal-article","created":{"date-parts":[[2010,5,5]],"date-time":"2010-05-05T02:40:20Z","timestamp":1273027220000},"page":"289-293","source":"Crossref","is-referenced-by-count":12,"title":["Hair Methylmercury: A New Indication for Therapeutic Monitoring"],"prefix":"10.1097","volume":"32","author":[{"given":"Katherine","family":"Schoeman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Bend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon","family":"Koren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210129","first-page":"29","article-title":"Vulnerable periods of brain development. In: Lipids, malnutrition the developing brain.","volume":"9-","author":"Dobbing","year":"1971","journal-title":"Ciba found Symp"},{"key":"R2-11-20210129","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0300-483X(99)00198-5","article-title":"Toxicologic evidence of developmental neurotoxicity of environmental chemicals.","volume":"144","author":"Andersen","year":"2000","journal-title":"Toxicology"},{"key":"R3-11-20210129","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.envres.2003.12.007","article-title":"Temporal variation of blood and hair mercury levels in relation to fish consumption history in a population living along the St. Lawrence River.","volume":"95","author":"Morrissette","year":"2004","journal-title":"Environ Res"},{"key":"R4-11-20210129","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1469-8749.1985.tb04581.x","article-title":"The development of the human blood-CSF-brain barrier.","volume":"27","author":"Adinolfi","year":"1985","journal-title":"Dev Med Child Neurol"},{"key":"R5-11-20210129","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1016\/S0140-6736(06)69665-7","article-title":"Developmental neurotoxicity of industrial chemicals.","volume":"368","author":"Grandjean","year":"2006","journal-title":"Lancet"},{"key":"R6-11-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/10408449509089885","article-title":"Minamata disease: methylmercury poisoning in Japan caused by environmental pollution.","volume":"25","author":"Harada","year":"1995","journal-title":"Crit Rev Toxicol"},{"key":"R7-11-20210129","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1542\/peds.54.5.587","article-title":"Intra-uterine methylmercury poisoning in Iraq.","volume":"54","author":"Amin-Zaki","year":"1974","journal-title":"Pediatrics"},{"key":"R9-11-20210129","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0892-0362(97)00097-4","article-title":"Cognitive deficit in 7-year old children with prenatal exposure to methylmercury.","volume":"19","author":"Grandjean","year":"1997","journal-title":"Neurotoxicol Teratol"},{"key":"R10-11-20210129","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1289\/ehp.9329","article-title":"Maternal fish consumption, mercury levels, and risk of preterm delivery.","volume":"115","author":"Xue","year":"2007","journal-title":"Environ Health Perspect"},{"key":"R11-11-20210129","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1289\/ehp.9216","article-title":"Response inhibition during differential reinforcement of low rates (DRL) schedules may be sensitive to low-level polychlorinated biphenyl, methylmercury, and lead exposure in children.","volume":"114","author":"Stewart","year":"2006","journal-title":"Environ Health Perspect"},{"key":"R12-11-20210129","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.envres.2007.05.015","article-title":"Prenatal exposure to mercury and neurobehavioral development of neonates in Zhoushan city, China.","volume":"105","author":"Gao","year":"2007","journal-title":"Environ Res"},{"key":"R13-11-20210129","doi-asserted-by":"crossref","first-page":"e289","DOI":"10.1542\/peds.111.3.e289","article-title":"Tagum study II: follow-up study at two years of age after prenatal exposure to mercury.","volume":"111","author":"Ramirez","year":"2003","journal-title":"Pediatrics"},{"key":"R14-11-20210129","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3402\/ijch.v61i1.17404","article-title":"Neurobehavioral performance of Inuit children with increased prenatal exposure to methylmercury.","volume":"61","author":"Weihe","year":"2002","journal-title":"Int J Circumpolar Health"},{"key":"R15-11-20210129","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/oxfordjournals.aje.a113652","article-title":"Methyl mercury exposure in northern Quebec. II. Neurologic findings in children.","volume":"118","author":"McKeown-Eyssen","year":"1983","journal-title":"Am J Epidemiol"},{"key":"R16-11-20210129","first-page":"343348","article-title":"Delayed evoked potentials in children exposed to methylmercury from seafood.","volume":"21","author":"Murata","year":"1999","journal-title":"Neurotoxicol Teratol"},{"key":"R17-11-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/enrs.2002.4349","article-title":"Neurodevelopmental investigations among methylmercury-exposed children in French Guiana.","volume":"89","author":"Cordier","year":"2002","journal-title":"Environ Res"},{"key":"R18-11-20210129","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1289\/ehp.10831","article-title":"Relation between cord blood mercury levels and early child development in a world trade center cohort.","volume":"116","author":"Lederman","year":"2008","journal-title":"Environ Health Perspect"},{"key":"R19-11-20210129","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neuro.2006.02.008","article-title":"Alterations of visual evoked potentials in preschool Inuit children exposed to methylmercury and polychlorinated biphenyls from a marine diet.","volume":"27","author":"Saint-Amour","year":"2006","journal-title":"Neurotoxicology"},{"key":"R20-11-20210129","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/oxfordjournals.aje.a115660","article-title":"Dietary intake of methylmercury as a correlate of gestational length and birth weight among newborns in Greenland.","volume":"132","author":"Foldspang","year":"1990","journal-title":"Am J Epidemiol"},{"key":"R21-11-20210129","first-page":"149","article-title":"Prenatal low-level methyl mercury exposure and child development in an Italian coastal area.","volume":"7","author":"Barbone","year":"2004","journal-title":"SMDJ"},{"key":"R22-11-20210129","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/clpt.1988.42","article-title":"Therapeutic drug monitoring.","volume":"43","author":"Spector","year":"1988","journal-title":"Clin Pharmacol Ther"},{"key":"R24-11-20210129","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra022471","article-title":"The toxicology of mercury-current exposures and clinical manifestations.","volume":"349","author":"Clarkson","year":"2003","journal-title":"N Engl J Med"},{"key":"R25-11-20210129","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.envint.2008.09.003","article-title":"Non-invasive matrices in human biomonitoring: A review.","volume":"35","author":"Esteban","year":"2009","journal-title":"Environ Int"},{"key":"R26-11-20210129","first-page":"705","article-title":"Monitoring methylmercury during pregnancy: maternal hair predicts fetal brain exposure.","volume":"16","author":"Cernichiari","year":"1995","journal-title":"Neurotoxicology"},{"key":"R27-11-20210129","first-page":"613","article-title":"The biological monitoring of mercury in the Seychelles study.","volume":"16","author":"Cernichiari","year":"1995","journal-title":"Neurotoxicology"},{"key":"R28-11-20210129","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.neuro.2007.02.009","article-title":"The biological monitoring of prenatal exposure to methylmercury.","volume":"28","author":"Cernichiari","year":"2007","journal-title":"Neurotoxicology"},{"key":"R29-11-20210129","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0013-9351(05)80087-8","article-title":"Uptake of mercury by the hair of methylmercury-treated newborn mice.","volume":"51","author":"Shi","year":"1990","journal-title":"Environ Res"},{"key":"R30-11-20210129","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/jat.1307","article-title":"Validity of methyl mercury hair analysis: mercury monitoring in human scalp\/nude mouse model.","volume":"28","author":"Zareba","year":"2008","journal-title":"J Appl Toxicol"},{"key":"R31-11-20210129","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/00039896.1992.9938348","article-title":"Impact of maternal seafood diet on fetal exposure to mercury, selenium and lead.","volume":"47","author":"Grandjean","year":"1992","journal-title":"Arch Environ Health"},{"key":"R32-11-20210129","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1006\/enrs.1998.3831","article-title":"Longitudinal hair mercury concentration in riverside mothers along the Upper Madeira river (Brazil).","volume":"77","author":"Boischio","year":"1998","journal-title":"Environ Res"},{"key":"R33-11-20210129","first-page":"208","article-title":"Effects of hair treatment on hair mercury-the best biomarker of methylmercury exposure?","volume":"10","author":"Dakeishi","year":"2005","journal-title":"Environ Health Perspect"},{"key":"R34-11-20210129","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1289\/ehp.7046","article-title":"Hair mercury levels in U.S. children and women of childbearing age: reference range data from NHANES 1999-2000.","volume":"112","author":"McDowell","year":"2004","journal-title":"Environ Health Perspect"},{"key":"R35-11-20210129","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1007\/s00244-002-1257-5","article-title":"Results of multiyear international interlaboratory comparison program for mercury in human hair.","volume":"43","author":"Gill","year":"2002","journal-title":"Arch Environ Contam Toxicol"},{"key":"R36-11-20210129","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/sj.jea.7500056","article-title":"Analysis of mercury in hair of EPA region V population.","volume":"9","author":"Pellizzari","year":"1999","journal-title":"J Expo Anal Environ Epidemiol"},{"key":"R37-11-20210129","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0147-6513(03)00060-5","article-title":"Cases of mercury exposure, bioavailability, and absorption.","volume":"56","author":"Gochfeld","year":"2003","journal-title":"Ecotoxicol Environ Saf"},{"key":"R38-11-20210129","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/00039896.1980.10667458","article-title":"The relationship between blood levels and dose of methylmercury in man.","volume":"35","author":"Kershaw","year":"1980","journal-title":"Arch Environ Health"},{"key":"R39-11-20210129","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.envres.2004.07.001","article-title":"Fish consumption, advisory awareness, and hair mercury levels among women of childbearing age.","volume":"97","author":"Knobeloch","year":"2005","journal-title":"Environ Res"},{"key":"R40-11-20210129","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/ajim.20476","article-title":"Mechanisms of mercury disposition in the body.","volume":"50","author":"Clarkson","year":"2007","journal-title":"Am J Ind Med"},{"key":"R41-11-20210129","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1080\/15287398609530940","article-title":"Dose- and sex-dependent alterations in mercury distribution in fetal mice following methylmercury exposure.","volume":"19","author":"Inouye","year":"1986","journal-title":"J Toxicol Environ Health"},{"key":"R42-11-20210129","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0002-9378(81)90448-8","article-title":"Comparison of mercury levels in maternal blood, fetal cord blood, and placental tissues.","volume":"139","author":"Kuhnert","year":"1981","journal-title":"Am J Obstet Gynecol"},{"key":"R43-11-20210129","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/0272-0590(85)90165-4","article-title":"Biliary secretion of glutathione and of glutathione-metal complexes.","volume":"5","author":"Ballatori","year":"1985","journal-title":"Fundam Appl Toxicol"},{"key":"R44-11-20210129","first-page":"1469","article-title":"Impaired biliary excretion and whole body elimination of methylmercury in rats with congenital defect in biliary glutathione excretion.","volume":"22","author":"Ballatori","year":"1995","journal-title":"Hepatology"},{"key":"R46-11-20210129","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3109\/00498257809060381","article-title":"Metabolism of methylmercuric chloride by the gastro-intestinal flora of the rat.","volume":"8","author":"Rowland","year":"1978","journal-title":"Xenobiotica"},{"key":"R47-11-20210129","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1539-6924.1999.tb00427.x","article-title":"Evaluation of the uncertainty in an oral reference dose for methylmercury due to interindividual variability in pharmacokinetics.","volume":"19","author":"Clewell","year":"1999","journal-title":"Risk Anal"},{"key":"R48-11-20210129","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1006\/rtph.1997.1105","article-title":"Estimation of the interindividual variability in the one-compartment pharmacokinetic model for methylmercury: implications for the derivation of a reference dose.","volume":"25","author":"Stern","year":"1997","journal-title":"Regul Toxicol Pharmacol"},{"key":"R50-11-20210129","first-page":"640","article-title":"Dose-response analysis of infants prenatally exposed to methylmercury: an application of a single compartment model to single-strand hair analyses.","volume":"31","author":"Cox","year":"1989","journal-title":"Environ Res"},{"key":"R52-11-20210129","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1093\/clinchem\/40.7.1395","article-title":"Methylmercury: significance of intrauterine and postnatal exposures.","volume":"40","author":"Grandjean","year":"1994","journal-title":"Clin Chem"},{"key":"R53-11-20210129","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00005072-197811000-00001","article-title":"Abnormal neuronal migration, deranged cerebral cortical organization, and diffuse white matter astrocytosis of human fetal brain: a major effect of methylmercury poisoning in utero.","volume":"37","author":"Choi","year":"1978","journal-title":"J Neuropathol Exp Neurol"},{"key":"R54-11-20210129","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1136\/jnnp.17.4.235","article-title":"Focal cerebral and cerebellar atrophy in a human subject due to organic mercury compounds.","volume":"17","author":"Hunter","year":"1954","journal-title":"J Neurol Neurosurg"},{"key":"R56-11-20210129","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0361-9230(01)00458-0","article-title":"Neurotoxicity and molecular effects of methylmercury.","volume":"55","author":"Castoldi","year":"2001","journal-title":"Brain Res Bull"},{"key":"R58-11-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/enrs.2000.4084","article-title":"Neurodevelopmental outcomes of Seychellois children from the pilot cohort at 108 months following prenatal exposure to methylmercury from a maternal fish diet.","volume":"84","author":"Davidson","year":"2000","journal-title":"Environ Res"},{"key":"R59-11-20210129","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ntt.2004.12.001","article-title":"Neuromotor functions in Inuit preschool children exposed to Pb, PCBs, and Hg.","volume":"27","author":"Despres","year":"2005","journal-title":"Neurotoxicol Teratol"},{"key":"R60-11-20210129","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1006\/enrs.1997.3804","article-title":"Cognitive performance of children prenatally exposed to safe levels of methylmercury.","volume":"77","author":"Grandjean","year":"1998","journal-title":"Environ Res"},{"key":"R62-11-20210129","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jpeds.2003.10.059","article-title":"Delayed brainstem auditory evoked potential latencies in 14-year-old children exposed to methylmercury.","volume":"144","author":"Murata","year":"2004","journal-title":"J Pediatr"},{"key":"R63-11-20210129","first-page":"639","article-title":"Neurodevelopmental outcomes of Seychellois children sixty-six months after in utero exposure to methylmercury from a maternal fish diet: pilot study.","volume":"16","author":"Myers","year":"1995","journal-title":"Neurotoxicology"},{"key":"R64-11-20210129","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/S0140-6736(03)13371-5","article-title":"Prenatal methylmercury exposure from ocean fish consumption in the Seychelles child development study.","volume":"361","author":"Myers","year":"2003","journal-title":"Lancet"},{"key":"R65-11-20210129","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1289\/ehp.8041","article-title":"Maternal fish consumption, hair mercury, and infant cognition in a U.S. cohort.","volume":"113","author":"Oken","year":"2005","journal-title":"Environ Health Perspect"},{"key":"R66-11-20210129","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1067\/mpd.2000.102774","article-title":"Maternal seafood diet, methylmercury exposure, and neonatal neurologic function.","volume":"136","author":"Steuerwald","year":"2000","journal-title":"J Pediatr"},{"key":"R67-11-20210129","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/j.neuro.2008.06.002","article-title":"Associations of maternal long-chain polyunsaturated fatty acids, methyl mercury, and infant development in the Seychelles child development nutrition study.","volume":"29","author":"Strain","year":"2008","journal-title":"Neurotoxicology"},{"key":"R68-11-20210129","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0892-0362(99)00026-4","article-title":"Evoked potentials in Faroese children prenatally exposed to methylmercury.","volume":"21","author":"Murata","year":"1999","journal-title":"Neurotoxicol Teratol"}],"container-title":["Therapeutic Drug Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/FTD.0b013e3181db99a8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:17:28Z","timestamp":1786040248000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007691-201006000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/ftd.0b013e3181db99a8","relation":{},"ISSN":["0163-4356"],"issn-type":[{"value":"0163-4356","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}