{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:10:40Z","timestamp":1786119040058,"version":"build-2736575974"},"reference-count":49,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1097\/gco.0b013e3282f10e33","type":"journal-article","created":{"date-parts":[[2009,3,4]],"date-time":"2009-03-04T20:45:32Z","timestamp":1236199532000},"page":"573-577","source":"Crossref","is-referenced-by-count":44,"title":["The use of low-molecular-weight heparins in pregnancy \u2013 how safe are they?"],"prefix":"10.1097","volume":"19","author":[{"given":"Philippe","family":"Deruelle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Capucine","family":"Coulon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20210129","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1111\/j.1365-2141.2004.05304.x","article-title":"Low molecular weight heparin in pregnancy: current issues","volume":"128","author":"Greer","year":"2005","journal-title":"Br J Haematol"},{"key":"R2-12-20210129","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.1365-2141.2006.06480.x","article-title":"Reduction of high fetal loss rate by anticoagulant treatment during pregnancy in antithrombin, protein C or protein S deficient women","volume":"136","author":"Folkeringa","year":"2007","journal-title":"Br J Haematol"},{"key":"R3-12-20210129","first-page":"243","article-title":"Absence of transplacental passage of the low molecular weight heparin enoxaparin","volume":"30","author":"Dimitrakakis","year":"2000","journal-title":"Haemostasis"},{"key":"R4-12-20210129","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1055\/s-0038-1646526","article-title":"Low molecular weight heparin Novo (LHN-1) does not cross the placenta during the second trimester of pregnancy","volume":"61","author":"Omri","year":"1989","journal-title":"Thromb Haemost"},{"key":"R5-12-20210129","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0301-2115(99)00008-1","article-title":"Anticoagulant therapy in pregnancy","volume":"83","author":"Robin","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R6-12-20210129","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1182\/blood-2005-02-0626","article-title":"Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review of safety and efficacy","volume":"106","author":"Greer","year":"2005","journal-title":"Blood"},{"key":"R7-12-20210129","first-page":"1134","article-title":"Venous thromboembolism during pregnancy: a retrospective study of enoxaparin safety in 624 pregnancies","volume":"108","author":"Lepercq","year":"2001","journal-title":"BJOG"},{"key":"R8-12-20210129","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-0037-1613984","article-title":"Bleeding complications associated with low molecular weight heparin prophylaxis during pregnancy","volume":"84","author":"Lindqvist","year":"2000","journal-title":"Thromb Haemost"},{"key":"R9-12-20210129","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1160\/TH06-11-0650","article-title":"Venous thromboembolism during pregnancy or postpartum: findings from the RIETE Registry","volume":"97","author":"Blanco-Molina","year":"2007","journal-title":"Thromb Haemost"},{"key":"R10-12-20210129","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/sj.jp.7211745","article-title":"Low-molecular-weight heparin in pregnancy: peripartum bleeding complications","volume":"27","author":"Kominiarek","year":"2007","journal-title":"J Perinatol"},{"key":"R11-12-20210129","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/14767050400028626","article-title":"The safety of low molecular weight heparin therapy during labor","volume":"17","author":"Maslovitz","year":"2005","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"3","key":"R12-12-20210129","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1097\/01.AOG.0000204868.25294.8f","article-title":"Massive subchorionic hematoma associated with enoxaparin","volume":"108","author":"Lee","year":"2006","journal-title":"Obstet Gynecol"},{"key":"R13-12-20210129","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199505183322003","article-title":"Heparin-induced thrombocytopenia in patients treated with low-molecular-weight heparin or unfractionated heparin","volume":"332","author":"Warkentin","year":"1995","journal-title":"N Engl J Med"},{"key":"R14-12-20210129","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1067\/mob.2001.114690","article-title":"Heparin-induced thrombocytopenia is rare in pregnancy","volume":"185","author":"Fausett","year":"2001","journal-title":"Am J Obstet Gynecol"},{"key":"R15-12-20210129","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1160\/TH04-06-0345","article-title":"Treatment of 51 pregnancies with danaparoid because of heparin intolerance","volume":"93","author":"Lindhoff-Last","year":"2005","journal-title":"Thromb Haemost"},{"key":"R16-12-20210129","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1160\/TH06-10-0577","article-title":"Fondaparinux is an effective alternative anticoagulant in pregnant women with high risk of venous thromboembolism and intolerance to low-molecular-weight heparins and heparinoids","volume":"97","author":"Gerhardt","year":"2007","journal-title":"Thromb Haemost"},{"key":"R17-12-20210129","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1182\/blood-2006-03-009548","article-title":"Fondaparinux is a safe alternative in case of heparin intolerance during pregnancy","volume":"108","author":"Mazzolai","year":"2006","journal-title":"Blood"},{"key":"R18-12-20210129","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1056\/NEJM200404293501825","article-title":"Minor transplacental passage of fondaparinux in vivo","volume":"350","author":"Dempfle","year":"2004","journal-title":"N Engl J Med"},{"key":"R19-12-20210129","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.fertnstert.2005.03.048","article-title":"Effects of enoxaparin on late pregnancy complications and neonatal outcome in women with recurrent pregnancy loss and thrombophilia: results from the LIVE-ENOX study","volume":"84","author":"Brenner","year":"2005","journal-title":"Fertil Steril"},{"key":"R20-12-20210129","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ejogrb.2005.09.010","article-title":"Use of low-molecular-weight heparin from the first trimester of pregnancy: a retrospective study of 111 consecutive pregnancies","volume":"127","author":"Deruelle","year":"2006","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R21-12-20210129","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1055\/s-0037-1615222","article-title":"The effects of standard and low molecular weight heparin on bone nodule formation in vitro","volume":"80","author":"Bhandari","year":"1998","journal-title":"Thromb Haemost"},{"key":"R22-12-20210129","first-page":"635","article-title":"Effects of standard heparin and low-molecular-weight heparins on the formation of murine osteoclasts in vitro","volume":"57","author":"Folwarczna","year":"2005","journal-title":"Pharmacol Rep"},{"key":"R23-12-20210129","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00001721-199504000-00004","article-title":"Long-term administration of heparin and heparin fractions and osteoporosis in experimental animals","volume":"6","author":"Murray","year":"1995","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R24-12-20210129","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1182\/blood.V93.4.1231","article-title":"A histomorphometric evaluation of heparin-induced bone loss after discontinuation of heparin treatment in rats","volume":"93","author":"Shaughnessy","year":"1999","journal-title":"Blood"},{"key":"R25-12-20210129","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-0038-1655903","article-title":"Thromboprophylaxis with low molecular weight heparin (Fragmin) in high risk pregnancies","volume":"77","author":"Hunt","year":"1997","journal-title":"Thromb Haemost"},{"key":"R26-12-20210129","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1055\/s-0038-1646338","article-title":"Use of low molecular weight heparin in pregnancy","volume":"68","author":"Melissari","year":"1992","journal-title":"Thromb Haemost"},{"key":"R27-12-20210129","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/S0002-9378(97)70403-4","article-title":"Low-molecular-weight heparin for obstetric thromboprophylaxis: experience of sixty-nine pregnancies in sixty-one women at high risk","volume":"176","author":"Nelson-Piercy","year":"1997","journal-title":"Am J Obstet Gynecol"},{"key":"R28-12-20210129","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0301-2115(95)02358-5","article-title":"Bone density studies in pregnant women receiving heparin","volume":"65","author":"Shefras","year":"1996","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R29-12-20210129","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/S0002-9378(94)70299-3","article-title":"A prospective study of heparin-induced osteoporosis in pregnancy using bone densitometry","volume":"170","author":"Barbour","year":"1994","journal-title":"Am J Obstet Gynecol"},{"key":"R30-12-20210129","first-page":"122","article-title":"Prospective evaluation of bone density in pregnant women receiving the low molecular weight heparin enoxaparin sodium","volume":"9","author":"Casele","year":"2000","journal-title":"J Matern Fetal Med"},{"key":"R31-12-20210129","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ajog.2006.06.080","article-title":"Bone density changes in women who receive thromboprophylaxis in pregnancy","volume":"195","author":"Casele","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"R32-12-20210129","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1538-7836.2004.01090.x","article-title":"Efficacy and safety of two doses of enoxaparin in women with thrombophilia and recurrent pregnancy loss: the LIVE-ENOX study","volume":"3","author":"Brenner","year":"2005","journal-title":"J Thromb Haemost"},{"key":"R33-12-20210129","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1439-0264.2005.00642.x","article-title":"Investigation of direct toxic and teratogenic effects of anticoagulants on rat embryonic development using in vitro culture method and genotoxicity assay","volume":"35","author":"Uysal","year":"2006","journal-title":"Anat Histol Embryol"},{"key":"R34-12-20210129","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1055\/s-0037-1614550","article-title":"Safety of low-molecular-weight heparin in pregnancy: a systematic review","volume":"81","author":"Sanson","year":"1999","journal-title":"Thromb Haemost"},{"key":"R35-12-20210129","first-page":"1","article-title":"Thromboprophylaxis with low molecular mass heparin, \u2018Fragmin\u2019 (dalteparin), during pregnancy \u2013 a longitudinal safety study","volume":"9","author":"Blomback","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R36-12-20210129","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.fertnstert.2005.12.068","article-title":"A randomized study of thromboprophylaxis in women with unexplained consecutive recurrent miscarriages","volume":"86","author":"Dolitzky","year":"2006","journal-title":"Fertil Steril"},{"key":"R37-12-20210129","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/0029-7844(95)00452-1","article-title":"Low-molecular-weight heparin during pregnancy and delivery: preliminary experience with 41 pregnancies","volume":"87","author":"Dulitzki","year":"1996","journal-title":"Obstet Gynecol"},{"key":"R38-12-20210129","first-page":"55","article-title":"Low molecular weight heparin as thromboprophylaxis in pregnancy. A retrospective analysis from 14 European clinics","volume":"24","author":"Wahlberg","year":"1994","journal-title":"Haemostasis"},{"key":"R40-12-20210129","first-page":"314","article-title":"Lack of antifactor Xa activity in umbilical cord vein samples after subcutaneous administration of heparin or low molecular mass heparin in pregnant women","volume":"23","author":"Harenberg","year":"1993","journal-title":"Haemostasis"},{"key":"R41-12-20210129","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/S0140-6736(03)12771-7","article-title":"Thrombophilic disorders and fetal loss: a meta-analysis","volume":"361","author":"Rey","year":"2003","journal-title":"Lancet"},{"key":"R42-12-20210129","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1055\/s-0037-1613894","article-title":"Gestational outcome in thrombophilic women with recurrent pregnancy loss treated by enoxaparin","volume":"83","author":"Brenner","year":"2000","journal-title":"Thromb Haemost"},{"key":"R43-12-20210129","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0015-0282(02)03222-3","article-title":"Preventing adverse obstetric outcomes in women with genetic thrombophilia","volume":"78","author":"Grandone","year":"2002","journal-title":"Fertil Steril"},{"key":"R44-12-20210129","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3109\/10641950109152640","article-title":"Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias","volume":"20","author":"Kupferminc","year":"2001","journal-title":"Hypertens Pregnancy"},{"key":"R45-12-20210129","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0301-2115(98)00083-9","article-title":"Low-molecular-weight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study","volume":"80","author":"Riyazi","year":"1998","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R46-12-20210129","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1046\/j.1538-7836.2003.00066.x","article-title":"Thromboprophylaxis improves the live birth rate in women with consecutive recurrent miscarriages and hereditary thrombophilia","volume":"1","author":"Carp","year":"2003","journal-title":"J Thromb Haemost"},{"key":"R47-12-20210129","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1182\/blood-2003-12-4250","article-title":"Low-molecular-weight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder","volume":"103","author":"Gris","year":"2004","journal-title":"Blood"},{"key":"R48-12-20210129","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/humrep\/14.2.489","article-title":"Low-molecular-weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome","volume":"14","author":"Di Simone","year":"1999","journal-title":"Hum Reprod"},{"key":"R49-12-20210129","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.placenta.2006.04.001","article-title":"Low-molecular-weight heparin induces in vitro trophoblast invasiveness: role of matrix metalloproteinases and tissue inhibitors","volume":"28","author":"Di Simone","year":"2007","journal-title":"Placenta"},{"key":"R50-12-20210129","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1093\/humrep\/del262","article-title":"Investigation of the effects of heparin and low molecular weight heparin on E-cadherin and laminin expression in rat pregnancy by immunohistochemistry","volume":"21","author":"Erden","year":"2006","journal-title":"Hum Reprod"}],"container-title":["Current Opinion in Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/GCO.0b013e3282f10e33","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:37:50Z","timestamp":1786037870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001703-200712000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/gco.0b013e3282f10e33","relation":{},"ISSN":["1040-872X"],"issn-type":[{"value":"1040-872X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}