{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:58Z","timestamp":1786119478608,"version":"build-2736575974"},"reference-count":73,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1097\/gco.0b013e32833bb425","type":"journal-article","created":{"date-parts":[[2010,6,11]],"date-time":"2010-06-11T11:24:58Z","timestamp":1276255498000},"page":"264-270","source":"Crossref","is-referenced-by-count":21,"title":["Molecular causes of hypogonadotropic hypogonadism"],"prefix":"10.1097","volume":"22","author":[{"given":"Ali Kemal","family":"Topaloglu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leman Damla","family":"Kotan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-3-20210129","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1111\/j.1365-2826.2008.01708.x","article-title":"Hypothalamic control of the pituitary\u2013gonadal axis in higher primates: key advances over the last two decades","volume":"20","author":"Plant","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"R2-3-20210129","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/nn1326","article-title":"The neural basis of puberty and adolescence","volume":"7","author":"Sisk","year":"2004","journal-title":"Nat Neurosci"},{"key":"R4-3-20210129","first-page":"29","article-title":"New genes controlling human reproduction and how you find them","volume":"119","author":"Crowley","year":"2008","journal-title":"Trans Am Clin Climatol Assoc"},{"key":"R5-3-20210129","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2265.2009.03687.x","article-title":"The recent genetics of hypogonadotrophic hypogonadism: novel insights and new questions","volume":"72","author":"Semple","year":"2010","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R6-3-20210129","first-page":"3010","article-title":"The neuroradiology of Kallmann's syndrome: a genotypic and phenotypic analysis","volume":"81","author":"Quinton","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"R7-3-20210129","first-page":"521","article-title":"Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations","volume":"19","author":"Seminara","year":"1998","journal-title":"Endocr Rev"},{"key":"R8-3-20210129","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1056\/NEJM199702063360604","article-title":"Adult-onset idiopathic hypogonadotropic hypogonadism \u2013 a treatable form of male infertility","volume":"336","author":"Nachtigall","year":"1997","journal-title":"N Engl J Med"},{"key":"R9-3-20210129","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1172\/JCI29884","article-title":"Digenic mutations account for variable phenotypes in idiopathic hypogonadotropic hypogonadism","volume":"117","author":"Pitteloud","year":"2007","journal-title":"J Clin Invest"},{"key":"R10-3-20210129","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1056\/NEJM199206253262606","article-title":"Brief report: intragenic deletion of the KALIG-1 gene in Kallmann's syndrome","volume":"326","author":"Bick","year":"1992","journal-title":"N Engl J Med"},{"key":"R11-3-20210129","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1038\/353529a0","article-title":"A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules","volume":"353","author":"Franco","year":"1991","journal-title":"Nature"},{"key":"R12-3-20210129","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/0092-8674(91)90193-3","article-title":"The candidate gene for the X-linked Kallmann syndrome encodes a protein related to adhesion molecules","volume":"67","author":"Legouis","year":"1991","journal-title":"Cell"},{"key":"R13-3-20210129","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1002\/humu.9298","article-title":"Kallmann syndrome: 14 novel mutations in KAL1 and FGFR1 (KAL2)","volume":"25","author":"Albuisson","year":"2005","journal-title":"Hum Mutat"},{"key":"R14-3-20210129","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/molehr\/gan027","article-title":"The prevalence of intragenic deletions in patients with idiopathic hypogonadotropic hypogonadism and Kallmann syndrome","volume":"14","author":"Pedersen-White","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"R15-3-20210129","first-page":"1532","article-title":"The importance of autosomal genes in Kallmann syndrome: genotype\u2013phenotype correlations and neuroendocrine characteristics","volume":"86","author":"Oliveira","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-3-20210129","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1210\/jc.2007-1168","article-title":"Kallmann's syndrome: a comparison of the reproductive phenotypes in men carrying KAL1 and FGFR1\/KAL2 mutations","volume":"93","author":"Salenave","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R17-3-20210129","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/ncpendmet0119","article-title":"Mechanisms of disease: insights into X-linked and autosomal-dominant Kallmann syndrome","volume":"2","author":"Tsai","year":"2006","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"R18-3-20210129","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000152034","article-title":"The complex genetics of Kallmann syndrome: KAL1, FGFR1, FGF8, PROKR2, PROK2, et al.","volume":"2","author":"Hardelin","year":"2008","journal-title":"Sex Dev"},{"key":"R19-3-20210129","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mce.2006.04.021","article-title":"Mutations in fibroblast growth factor receptor 1 cause Kallmann syndrome with a wide spectrum of reproductive phenotypes","volume":"254\u2013255","author":"Pitteloud","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"R20-3-20210129","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1210\/jc.2005-2793","article-title":"Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia","volume":"91","author":"Trarbach","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"R21-3-20210129","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1210\/jc.2004-1361","article-title":"Reversible kallmann syndrome, delayed puberty, and isolated anosmia occurring in a single family with a mutation in the fibroblast growth factor receptor 1 gene","volume":"90","author":"Pitteloud","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R22-3-20210129","doi-asserted-by":"crossref","first-page":"6281","DOI":"10.1073\/pnas.0600962103","article-title":"Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism","volume":"103","author":"Pitteloud","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R23-3-20210129","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1210\/jc.2006-1183","article-title":"A mutation in the fibroblast growth factor receptor 1 gene causes fully penetrant normosmic isolated hypogonadotropic hypogonadism","volume":"92","author":"Xu","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R24-3-20210129","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/ng1122","article-title":"Loss-of-function mutations in FGFR1 cause autosomal dominant Kallmann syndrome","volume":"33","author":"Dode","year":"2003","journal-title":"Nat Genet"},{"key":"R25-3-20210129","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1210\/jc.2009-0179","article-title":"Impaired fibroblast growth factor receptor 1 signaling as a cause of normosmic idiopathic hypogonadotropic hypogonadism","volume":"94","author":"Raivio","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R26-3-20210129","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1172\/JCI34538","article-title":"Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice","volume":"118","author":"Falardeau","year":"2008","journal-title":"J Clin Invest"},{"key":"R27-3-20210129","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1126\/science.1112103","article-title":"Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling","volume":"308","author":"Ng","year":"2005","journal-title":"Science"},{"key":"R28-3-20210129","doi-asserted-by":"crossref","first-page":"17447","DOI":"10.1073\/pnas.0707173104","article-title":"Loss-of-function mutation in the prokineticin 2 gene causes Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism","volume":"104","author":"Pitteloud","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R29-3-20210129","doi-asserted-by":"crossref","first-page":"4140","DOI":"10.1073\/pnas.0508881103","article-title":"Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2","volume":"103","author":"Matsumoto","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-3-20210129","doi-asserted-by":"crossref","first-page":"e175","DOI":"10.1371\/journal.pgen.0020175","article-title":"Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2","volume":"2","author":"Dode","year":"2006","journal-title":"PLoS Genet"},{"key":"R31-3-20210129","doi-asserted-by":"crossref","first-page":"4113","DOI":"10.1210\/jc.2008-0958","article-title":"Loss-of-function mutations in the genes encoding prokineticin-2 or prokineticin receptor-2 cause autosomal recessive Kallmann syndrome","volume":"93","author":"Abreu","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R32-3-20210129","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1210\/jc.2007-2654","article-title":"Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum","volume":"93","author":"Cole","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"R33-3-20210129","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1210\/jc.2009-0843","article-title":"A comparative phenotypic study of Kallmann syndrome patients carrying monoallelic and biallelic mutations in the prokineticin 2 or prokineticin receptor 2 genes","volume":"95","author":"Sarfati","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R34-3-20210129","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1038\/ng1407","article-title":"Mutations in a new member of the chromodomain gene family cause CHARGE syndrome","volume":"36","author":"Vissers","year":"2004","journal-title":"Nat Genet"},{"key":"R35-3-20210129","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.ajhg.2008.09.005","article-title":"Mutations in CHD7, encoding a chromatin-remodeling protein, cause idiopathic hypogonadotropic hypogonadism and Kallmann syndrome","volume":"83","author":"Kim","year":"2008","journal-title":"Am J Hum Genet"},{"key":"R36-3-20210129","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1399-0004.2008.01107.x","article-title":"CHD7 mutations in patients initially diagnosed with Kallmann syndrome \u2013 the clinical overlap with CHARGE syndrome","volume":"75","author":"Jongmans","year":"2009","journal-title":"Clin Genet"},{"key":"R37-3-20210129","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10038-004-0137-4","article-title":"Characterization of the human nasal embryonic LHRH factor gene, NELF, and a mutation screening among 65 patients with idiopathic hypogonadotropic hypogonadism (IHH)","volume":"49","author":"Miura","year":"2004","journal-title":"J Hum Genet"},{"key":"R38-3-20210129","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/ng0398-213","article-title":"A leptin missense mutation associated with hypogonadism and morbid obesity","volume":"18","author":"Strobel","year":"1998","journal-title":"Nat Genet"},{"key":"R39-3-20210129","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1056\/NEJMoa063988","article-title":"Clinical and molecular genetic spectrum of congenital deficiency of the leptin receptor","volume":"356","author":"Farooqi","year":"2007","journal-title":"N Engl J Med"},{"key":"R40-3-20210129","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1056\/NEJM199909163411204","article-title":"Effects of recombinant leptin therapy in a child with congenital leptin deficiency","volume":"341","author":"Farooqi","year":"1999","journal-title":"N Engl J Med"},{"key":"R41-3-20210129","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/372672a0","article-title":"Mutations in the DAX-1 gene give rise to both X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism","volume":"372","author":"Muscatelli","year":"1994","journal-title":"Nature"},{"key":"R42-3-20210129","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJM199711273372205","article-title":"A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor","volume":"337","author":"De Roux","year":"1997","journal-title":"N Engl J Med"},{"key":"R43-3-20210129","first-page":"1580","article-title":"Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism","volume":"86","author":"Beranova","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R44-3-20210129","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.beem.2006.10.005","article-title":"GnRH receptor and GPR54 inactivation in isolated gonadotropic deficiency","volume":"20","author":"De Roux","year":"2006","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"R45-3-20210129","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1056\/NEJMoa0900136","article-title":"Isolated familial hypogonadotropic hypogonadism and a GNRH1 mutation","volume":"360","author":"Bouligand","year":"2009","journal-title":"N Engl J Med"},{"key":"R46-3-20210129","doi-asserted-by":"crossref","first-page":"11703","DOI":"10.1073\/pnas.0903449106","article-title":"GNRH1 mutations in patients with idiopathic hypogonadotropic hypogonadism","volume":"106","author":"Chan","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R47-3-20210129","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/35079135","article-title":"Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor","volume":"411","author":"Ohtaki","year":"2001","journal-title":"Nature"},{"key":"R48-3-20210129","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1056\/NEJMoa035322","article-title":"The GPR54 gene as a regulator of puberty","volume":"349","author":"Seminara","year":"2003","journal-title":"New Engl J Med"},{"key":"R49-3-20210129","doi-asserted-by":"crossref","first-page":"10972","DOI":"10.1073\/pnas.1834399100","article-title":"Hypogonadotropic hypogonadism due to loss of function of the Kiss1-derived peptide receptor GPR54","volume":"100","author":"De Roux","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R50-3-20210129","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1530\/eje.1.02031","article-title":"Role of sequence variations of the GNRH receptor and g protein-coupled receptor 54 gene in male idiopathic hypogonadotropic hypogonadism","volume":"153","author":"Lanfranco","year":"2005","journal-title":"E J Endocrinol"},{"key":"R51-3-20210129","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.1210\/jc.2004-1418","article-title":"Two novel missense mutations in g protein-coupled receptor 54 in a patient with hypogonadotropic hypogonadism","volume":"90","author":"Semple","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R52-3-20210129","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1210\/jc.2006-2147","article-title":"Neuroendocrine phenotype analysis in five patients with isolated hypogonadotropic hypogonadism due to a l102p inactivating mutation of GPR54","volume":"92","author":"Tenenbaum-Rakover","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"Suppl 1","key":"R53-3-20210129","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1530\/eje.1.02235","article-title":"Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism","volume":"155","author":"Cerrato","year":"2006","journal-title":"E J Endocrinol"},{"key":"R54-3-20210129","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1126\/science.2884728","article-title":"Homozygosity mapping: a way to map human recessive traits with the DNA of inbred children","volume":"236","author":"Lander","year":"1987","journal-title":"Science"},{"key":"R55-3-20210129","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/ng.306","article-title":"TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for neurokinin B in the central control of reproduction","volume":"41","author":"Topaloglu","year":"2009","journal-title":"Nat Genet"},{"key":"R56-3-20210129","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1210\/jc.2009-0551","article-title":"Hypogonadotropic hypogonadism due to a novel missense mutation in the first extracellular loop of the neurokinin b receptor","volume":"94","author":"Guran","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"R57-3-20210129","doi-asserted-by":"crossref","first-page":"3122","DOI":"10.1210\/jc.2004-2465","article-title":"A window of opportunity: the diagnosis of gonadotropin deficiency in the male infant","volume":"90","author":"Grumbach","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R58-3-20210129","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.ejphar.2004.05.016","article-title":"mRNA expression of tachykinins and tachykinin receptors in different human tissues","volume":"494","author":"Pinto","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"R59-3-20210129","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.brainres.2004.08.026","article-title":"Central injection of senktide, an NK3 receptor agonist, or Neuropeptide Y inhibits LH secretion and induces different patterns of fos expression in the rat hypothalamus","volume":"1026","author":"Sandoval-Guzm\u00e1n","year":"2004","journal-title":"Brain Res"},{"key":"R60-3-20210129","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1210\/er.2009-0005","article-title":"Kisspeptin signaling in the brain","volume":"30","author":"Oakley","year":"2009","journal-title":"Endocr Rev"},{"key":"R61-3-20210129","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1210\/en.2009-0190","article-title":"Regulation of food intake and gonadotropin-releasing hormone\/luteinizing hormone during lactation: role of insulin and leptin","volume":"150","author":"Xu","year":"2009","journal-title":"Endocrinology"},{"key":"R62-3-20210129","doi-asserted-by":"crossref","first-page":"E1212","DOI":"10.1152\/ajpendo.00461.2009","article-title":"Sex differences in the regulation of KiSS1\/NKB neurons in juvenile mice: implications for the timing of puberty","volume":"297","author":"Kauffman","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"R63-3-20210129","doi-asserted-by":"crossref","first-page":"11859","DOI":"10.1523\/JNEUROSCI.1569-09.2009","article-title":"Regulation of gonadotropin-releasing hormone secretion by Kisspeptin\/dynorphin\/neurokinin B neurons in the arcuate nucleus of the mouse","volume":"29","author":"Navarro","year":"2009","journal-title":"J Neurosci"},{"key":"R64-3-20210129","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2826.2009.01930.x","article-title":"Neurokinin 3 receptor immunoreactivity in the septal region, preoptic area and hypothalamus of the female sheep: colocalisation in neurokinin B cells of the arcuate nucleus but not in gonadotrophin-releasing hormone neurones","volume":"22","author":"Amstalden","year":"2010","journal-title":"J Neuroendocrinol"},{"key":"R65-3-20210129","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuroscience.2009.12.053","article-title":"Forebrain projections of arcuate neurokinin B neurons demonstrated by anterograde tract-tracing and monosodium glutamate lesions in the rat","volume":"166","author":"Krajewski","year":"2010","journal-title":"Neuroscience"},{"key":"R66-3-20210129","doi-asserted-by":"crossref","first-page":"5752","DOI":"10.1210\/en.2007-0961","article-title":"Kisspeptin neurons in the arcuate nucleus of the ewe express both dynorphin a and Neurokinin B","volume":"148","author":"Goodman","year":"2007","journal-title":"Endocrinology"},{"key":"R67-3-20210129","doi-asserted-by":"crossref","first-page":"3124","DOI":"10.1523\/JNEUROSCI.5848-09.2010","article-title":"Neurokinin B and dynorphin a in kisspeptin neurons of the arcuate nucleus participate in generation of periodic oscillation of neural activity driving pulsatile gonadotropin-releasing hormone secretion in the goat","volume":"30","author":"Wakabayashi","year":"2010","journal-title":"J Neurosci"},{"key":"R68-3-20210129","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/cne.21086","article-title":"Coexpression of dynorphin and neurokinin b immunoreactivity in the rat hypothalamus: morphologic evidence of interrelated function within the arcuate nucleus","volume":"498","author":"Burke","year":"2006","journal-title":"J Comp Neurol"},{"key":"R69-3-20210129","first-page":"372","article-title":"Morphologic evidence that neurokinin B modulates gonadotropin-releasing hormone secretion via neurokinin 3 receptors in the rat median eminence","volume":"489","author":"Krajewski","year":"2005","journal-title":"J Comp Endocrinol"},{"key":"R70-3-20210129","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1210\/en.2005-1261","article-title":"Repetitive activation of hypothalamic G protein-coupled receptor 54 with intravenous pulses of kisspeptin in the juvenile monkey (Macaca mulatta) elicits a sustained train of gonadotropin-releasing hormone discharges","volume":"147","author":"Plant","year":"2006","journal-title":"Endocrinology"},{"key":"R71-3-20210129","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.phrs.2004.07.002","article-title":"Tachykinin NK3-receptor deficiency does not inhibit pulmonary eosinophilia in allergic mice","volume":"50","author":"Kung","year":"2004","journal-title":"Pharmacol Res"},{"key":"R72-3-20210129","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1210\/endo-125-2-906","article-title":"Further studies on the role of the gonads in determining the ontogeny of gonadotropin secretion in the guinea pig (Cavia porcelus)","volume":"125","author":"Fraser","year":"1989","journal-title":"Endocrinology"},{"key":"R74-3-20210129","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1210\/en.2006-1529","article-title":"Inhibition of metastin (kisspeptin-54)-GPR54 signaling in the arcuate nucleus-median eminence region during lactation in rats","volume":"148","author":"Yamada","year":"2007","journal-title":"Endocrinology"},{"key":"R75-3-20210129","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1210\/jcem-50-1-163","article-title":"Correlation of luteinizing hormone-releasing factor-induced luteinizing hormone and follicle-stimulating hormone release from infancy to 19 years with the changing pattern of gonadotropin secretion in agonadal patients: relation to the restraint of puberty","volume":"50","author":"Conte","year":"1980","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Current Opinion in Obstetrics & Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/GCO.0b013e32833bb425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:23:20Z","timestamp":1786040600000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001703-201008000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/gco.0b013e32833bb425","relation":{},"ISSN":["1040-872X"],"issn-type":[{"value":"1040-872X","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}