{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T12:43:35Z","timestamp":1779108215373,"version":"3.51.4"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1097\/gme.0b013e318186d7e2","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T19:48:58Z","timestamp":1242935338000},"page":"301-306","source":"Crossref","is-referenced-by-count":67,"title":["Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women"],"prefix":"10.1097","volume":"16","author":[{"given":"Rosario","family":"D'Anna","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Letizia","family":"Cannata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Marini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Atteritano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Cancellieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Corrado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onofrio","family":"Triolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piero","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agostino","family":"Gaudio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Frisina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Bitto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Polito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Letteria","family":"Minutoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenica","family":"Altavilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena Bianca","family":"Adamo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Squadrito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-14-20210227","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1097\/00042192-200205000-00003","article-title":"A longitudinal study of the treatment of hot flushes: the Population Study in Gothemburg during a quarter of century.","volume":"9","author":"Rodstrom","year":"2002","journal-title":"Menopause"},{"key":"R2-14-20210227","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0378-5122(03)00181-6","article-title":"Effects of a 5 years of hormonal replacement therapy on menopausal symptoms and blood pressure: a randomized controlled study.","volume":"46","author":"Vestergaard","year":"2003","journal-title":"Maturitas"},{"key":"R3-14-20210227","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1001\/jama.288.3.321","article-title":"Risk and benefits of estrogen plus progestin in healthy postmenopausal women: principal results from the Women's Health Initiative randomized controlled trial.","volume":"288","author":"Rossouw","year":"2002","journal-title":"JAMA"},{"key":"R4-14-20210227","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/0378-5122(94)90068-X","article-title":"Climacteric and menopause in seven South-East Asian countries.","volume":"19","author":"Boulet","year":"1994","journal-title":"Maturitas"},{"key":"R5-14-20210227","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0140-6736(92)91174-7","article-title":"Dietary phytoestrogens and the menopause in Japan.","volume":"339","author":"Adlercreutz","year":"1992","journal-title":"Lancet"},{"key":"R6-14-20210227","doi-asserted-by":"crossref","first-page":"4252","DOI":"10.1210\/endo.139.10.6216","article-title":"Interaction of estrogenic chemical and phytoestrogens with estrogen receptor .","volume":"139","author":"Kuiper","year":"1998","journal-title":"Endocrinology"},{"key":"R7-14-20210227","doi-asserted-by":"crossref","first-page":"839","DOI":"10.7326\/0003-4819-146-12-200706190-00005","article-title":"Effects of the phytoestrogen genistein on bone metabolism in osteopenic postmenopausal women: a 2-years randomized, double-blind, placebo-controlled study.","volume":"146","author":"Marini","year":"2007","journal-title":"Ann Intern Med"},{"key":"R8-14-20210227","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1210\/jc.2006-2295","article-title":"Effects of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: a two-year randomized, double-blind, placebo-controlled study.","volume":"92","author":"Atteritano","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"R9-14-20210227","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1097\/01.gme.0000248708.60698.98","article-title":"Effects of the phytoestrogen genistein on hot flushes, endometrium, and vaginal epithelium in postmenopausal women: a 1-year randomized, double-blind, placebo controlled study.","volume":"14","author":"D'Anna","year":"2007","journal-title":"Menopause"},{"key":"R10-14-20210227","first-page":"249","article-title":"The maturation value.","volume":"11","author":"Meisels","year":"1967","journal-title":"Acta Cytol"},{"key":"R11-14-20210227","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/00042192-200007020-00006","article-title":"Clinical effects of a standardized soy extract in postmenopausal women: a pilot study.","volume":"7","author":"Scambia","year":"2000","journal-title":"Menopause"},{"key":"R12-14-20210227","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00042192-200007040-00005","article-title":"Vasomotor symptom relief by soy isoflavone extract tablets in post-menopausal women: a multicenter, double-blind, randomized, placebo-controlled study.","volume":"7","author":"Upmalis","year":"2000","journal-title":"Menopause"},{"key":"R13-14-20210227","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00042192-200101000-00005","article-title":"Isoflavone-rich or isoflavone-poor soy protein does not reduce menopausal symptoms during 24 weeks of treatment.","volume":"8","author":"St Germain","year":"2001","journal-title":"Menopause"},{"key":"R14-14-20210227","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1097\/00042192-200209000-00005","article-title":"Effects of a standardized soy extract on hot flushes: a multicenter, double-blind, randomized, placebo-controlled study.","volume":"9","author":"Drapier Faure","year":"2002","journal-title":"Menopause"},{"key":"R15-14-20210227","first-page":"CD001395","article-title":"Phytoestrogens for vasomotor menopausal symptoms.","volume":"4","author":"Lethaby","year":"2007","journal-title":"Cochrane Database Syst Rev"},{"key":"R16-14-20210227","first-page":"CD002978","article-title":"Oral oestrogen replacement therapy versus placebo for hot flushes.","volume":"1","author":"Mac Lennan","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"R17-14-20210227","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.maturitas.2003.09.026","article-title":"Benefits of soy germ isoflavones in postmenopausal women with contraindication for conventional hormone replacement therapy.","volume":"48","author":"Petri Nahas","year":"2004","journal-title":"Maturitas"},{"key":"R18-14-20210227","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00042192-200310020-00006","article-title":"Soy protein and isoflavones effects on vasomotor symptoms in peri- and postmenopausal women: the Soy Estrogen Alternative Study.","volume":"10","author":"Burke","year":"2003","journal-title":"Menopause"},{"key":"R19-14-20210227","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainresbull.2005.01.008","article-title":"Effects of dietary phytoestrogens on core body temperature during the estrous cycle and pregnancy.","volume":"65","author":"Bu","year":"2005","journal-title":"Brain Res Bull"},{"key":"R20-14-20210227","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/oxfordjournals.aje.a009270","article-title":"Association of soy and fiber consumption with the risk of endometrial cancer.","volume":"146","author":"Goodman","year":"1997","journal-title":"Am J Epidemiol"},{"key":"R21-14-20210227","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/jnci\/djg015","article-title":"Phytoestrogen intake and endometrial cancer risk.","volume":"95","author":"Horn-Ross","year":"2003","journal-title":"J Natl Cancer Inst"},{"key":"R22-14-20210227","first-page":"1713","article-title":"Stimulation of endometrial glandular cells with genistein and daidzein and their effects on ER- and ER-mRNA and protein expression.","volume":"25","author":"Staar","year":"2005","journal-title":"Anticancer Res"},{"key":"R23-14-20210227","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","article-title":"Genistein, a specific inhibitor of tyrosine-specific protein kinases.","volume":"262","author":"Akiyama","year":"1987","journal-title":"J Biol Chem"},{"key":"R24-14-20210227","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/biof.5520120133","article-title":"Isoflavonoids and chronic disease: mechanisms of action.","volume":"12","author":"Barnes","year":"2000","journal-title":"Biofactors"},{"key":"R25-14-20210227","doi-asserted-by":"crossref","first-page":"354S","DOI":"10.1080\/07315724.2001.10719168","article-title":"Soy isoflavones-benefits and risks from nature's selective estrogen receptor modulators (SERMs).","volume":"20","author":"Setchell","year":"2001","journal-title":"J Am Coll Nutr"},{"key":"R26-14-20210227","first-page":"261","article-title":"Effects of phytoestrogens and synthetic combinatorial libraries on aromatase, estrogen biosynthesis and metabolism.","volume":"13","author":"Brueggemeier","year":"2001","journal-title":"Ann N Y Acad Sci"},{"key":"R27-14-20210227","doi-asserted-by":"crossref","first-page":"17808","DOI":"10.1074\/jbc.M100953200","article-title":"Estrogen receptor -selective transcriptional activity and recruitment of coregulators by phytoestrogens.","volume":"276","author":"An","year":"2001","journal-title":"J Biol Chem"},{"key":"R28-14-20210227","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0301-2115(98)00281-4","article-title":"Phytoestrogens: the \"natural\" selective estrogen receptor modulators?","volume":"85","author":"Brzezinski","year":"1999","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"R29-14-20210227","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1073\/pnas.0308319100","article-title":"Estrogen receptor inhibits 17-estradiol-stimulated proliferation of the breast cancer cell line T47D.","volume":"101","author":"Strom","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R30-14-20210227","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1080\/gye.17.1.45.49","article-title":"Effects of genistein on the endometrium: ultrasonographic evaluation.","volume":"17","author":"Sammartino","year":"2003","journal-title":"Gynecol Endocrinol"},{"key":"R31-14-20210227","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.fertnstert.2003.11.041","article-title":"Endometrial effects of long-term treatment with phytoestrogens: a randomized, double-blind, placebo-controlled study.","volume":"82","author":"Unfer","year":"2004","journal-title":"Fertil Steril"},{"key":"R32-14-20210227","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1097\/gme.0b013e3180590c42","article-title":"Endometrial safety assessment of a specific and standardized soy extract according to international guidelines.","volume":"14","author":"Palacios","year":"2007","journal-title":"Menopause"},{"key":"R33-14-20210227","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.maturitas.2005.02.009","article-title":"Randomized clinical trial comparing conjugated equine estrogens and isoflavones in post-menopausal women: a pilot study.","volume":"53","author":"Kaari","year":"2006","journal-title":"Maturitas"},{"key":"R34-14-20210227","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/09513590500361192","article-title":"The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study.","volume":"21","author":"Hidalgo","year":"2005","journal-title":"Gynecol Endocrinol"}],"container-title":["Menopause"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00042192-200916020-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T01:31:07Z","timestamp":1618277467000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00042192-200916020-00014"}},"subtitle":["a 2-year randomized, double-blind, placebo-controlled study"],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/gme.0b013e318186d7e2","relation":{},"ISSN":["1072-3714"],"issn-type":[{"value":"1072-3714","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}