{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:43:18Z","timestamp":1791607398587,"version":"4.3.4"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Pulmonary embolism in pregnancy is a leading cause of maternal mortality. The clinical presentation is often nonspecific, making imaging essential for accurate diagnosis. After reviewing the literature on the radiologic diagnosis of pulmonary embolism in pregnancy, we concluded that both computed tomography pulmonary angiography and lung perfusion scintigraphy are sensitive with high positive predictive values in the presence of high clinical suspicion, but lung perfusion scintigraphy is recommended given lower maternal breast exposure to ionizing radiation and lower fetal contrast exposure. However, if a chest x-ray is abnormal, computed tomography pulmonary angiography is preferred due to high nondiagnostic rates of lung perfusion scintigraphy.<\/jats:p>","DOI":"10.1097\/grf.0000000000000366","type":"journal-article","created":{"date-parts":[[2018,4,24]],"date-time":"2018-04-24T16:46:34Z","timestamp":1524588394000},"page":"219-227","source":"Crossref","is-referenced-by-count":6,"title":["Radiologic Aspects of the Diagnosis of Pulmonary Embolism in Pregnancy"],"prefix":"10.1097","volume":"61","author":[{"given":"BENJAMIN S.","family":"HARRIS","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KATHERINE C.","family":"BISHOP","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"JEFFREY A.","family":"KULLER","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20230911","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/AOG.0b013e31821fd49d","article-title":"Changes in pregnancy mortality ascertainment: United States, 1999-2005","volume":"118","author":"MacKay","year":"2011","journal-title":"Obstet Gynecol"},{"key":"R2-20230911","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11239-013-0941-9","article-title":"Pulmonary embolism in pregnancy","volume":"37","author":"Conti","year":"2014","journal-title":"J Thromb Thrombolysis"},{"key":"R3-20230911","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/S0140-6736(09)60996-X","article-title":"Pulmonary embolism in pregnancy","volume":"375","author":"Bourjeily","year":"2010","journal-title":"Lancet"},{"key":"R4-20230911","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1164\/rccm.201108-1575ST","article-title":"An official American Thoracic Society\/Society of Thoracic Radiology clinical practice guideline: evaluation of suspected pulmonary embolism in pregnancy","volume":"184","author":"Leung","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"R5-20230911","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1001\/archinte.162.10.1170","article-title":"Suspected pulmonary embolism in pregnancy: clinical presentation, results of lung scanning, and subsequent maternal and pediatric outcomes","volume":"162","author":"Chan","year":"2002","journal-title":"Arch Intern Med"},{"key":"R6-20230911","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1053\/j.semperi.2013.04.002","article-title":"Pulmonary embolus in pregnancy","volume":"37","author":"Donnelly","year":"2013","journal-title":"Semin Perinatol"},{"key":"R7-20230911","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1097\/AOG.0b013e3182310c4c","article-title":"Thromboembolism in pregnancy. pracetice bulletin No. 123","volume":"118","year":"2011","journal-title":"Obstet Gynecol"},{"key":"R8-20230911","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ajog.2012.06.035","article-title":"New directions in the diagnosis and treatment of pulmonary embolism in pregnancy","volume":"208","author":"Cutts","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"R9-20230911","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1053\/j.sult.2011.09.001","article-title":"Pulmonary embolism evaluation in the pregnant patient: a review of current imaging approaches","volume":"33","author":"Cogley","year":"2012","journal-title":"Semin Ultrasound CT MR"},{"key":"R10-20230911","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2967\/jnmt.111.101386","article-title":"SNM practice guideline for lung scintigraphy 4.0","volume":"40","author":"Parker","year":"2012","journal-title":"J Nucl Med Technol"},{"key":"R11-20230911","first-page":"CD011053","article-title":"Imaging for the exclusion of pulmonary embolism in pregnancy","volume":"1","author":"van Mens","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"R12-20230911","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1148\/rg.293085226","article-title":"Quality initiatives: imaging pregnant patients with suspected pulmonary embolism: what the radiologist needs to know","volume":"29","author":"Pahade","year":"2009","journal-title":"Radiographics"},{"key":"R13-20230911","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2967\/jnumed.107.041988","article-title":"A reduced role of V\/Q scintigraphy in the diagnosis of acute pulmonary embolism","volume":"48","author":"Strashun","year":"2007","journal-title":"J Nucl Med"},{"key":"R14-20230911","doi-asserted-by":"crossref","first-page":"167","DOI":"10.2967\/jnumed.107.047274","article-title":"Merits of V\/Q SPECT scintigraphy compared with CTPA in imaging of pulmonary embolism","volume":"49","author":"Roach","year":"2008","journal-title":"J Nucl Med"},{"key":"R15-20230911","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.2967\/jnumed.113.124602","article-title":"V\/Q scanning using SPECT and SPECT\/CT","volume":"54","author":"Roach","year":"2013","journal-title":"J Nucl Med"},{"key":"R16-20230911","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1258\/om.2010.100065","article-title":"Use of imaging for investigation of suspected pulmonary embolism during pregnancy and the postpartum period","volume":"4","author":"Scott","year":"2011","journal-title":"Obstet Med"},{"key":"R17-20230911","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1111\/j.1538-7836.2012.04652.x","article-title":"Diagnostic accuracy of magnetic resonance imaging for an acute pulmonary embolism: results of the 'IRM-EP' study","volume":"10","author":"Revel","year":"2012","journal-title":"J Thromb Haemost"},{"key":"R18-20230911","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199705153362004","article-title":"Diagnosis of pulmonary embolism with magnetic resonance angiography","volume":"336","author":"Meaney","year":"1997","journal-title":"N Engl J Med"},{"key":"R19-20230911","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1148\/radiol.2443061693","article-title":"Discordance between CT angiography in the PIOPED II study","volume":"244","author":"Wittram","year":"2007","journal-title":"Radiology"},{"key":"R20-20230911","doi-asserted-by":"crossref","first-page":"941","DOI":"10.7326\/0003-4819-138-12-200306170-00005","article-title":"Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies. A systematic review","volume":"138","author":"Kruip","year":"2003","journal-title":"Ann Intern Med"},{"key":"R21-20230911","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1148\/radiol.2242011581","article-title":"Pulmonary embolism in pregnant patients: fetal radiation dose with helical CT","volume":"224","author":"Winer-Muram","year":"2002","journal-title":"Radiology"},{"key":"R22-20230911","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1148\/radiol.10100986","article-title":"Pulmonary embolism during pregnancy: diagnosis with lung scintigraphy or CT angiography?","volume":"258","author":"Revel","year":"2011","journal-title":"Radiology"},{"issue":"pt 1","key":"R23-20230911","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1097\/AOG.0b013e318180a505","article-title":"Guidelines for computed tomography and magnetic resonance imaging use during pregnancy and lactation","volume":"112","author":"Chen","year":"2008","journal-title":"Obstet Gynecol"},{"key":"R24-20230911","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1148\/rg.245045036","article-title":"MR imaging of maternal diseases of the abdomen and pelvis during pregnancy and the immediate postpartum period","volume":"24","author":"Leyendecker","year":"2004","journal-title":"Radiographics"},{"key":"R25-20230911","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1001\/jama.2016.12126","article-title":"Association between MRI exposure during pregnancy and fetal and childhood outcomes","volume":"316","author":"Ray","year":"2016","journal-title":"JAMA"},{"key":"R27-20230911","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/jmri.24011","article-title":"ACR guidance document on MR safe practices: 2013","volume":"37","author":"Kanal","year":"2013","journal-title":"J Magn Reson Imaging"},{"key":"R28-20230911","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1007\/s00330-004-2583-y","article-title":"The use of iodinated and gadolinium contrast media during pregnancy and lactation","volume":"15","author":"Webb","year":"2005","journal-title":"Eur Radiol"},{"key":"R29-20230911","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1016\/j.amjmed.2006.05.060","article-title":"Diagnostic pathways in acute pulmonary embolism: recommendations of the PIOPED II investigators","volume":"119","author":"Stein","year":"2006","journal-title":"Am J Med"},{"key":"R30-20230911","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.2214\/AJR.09.2360","article-title":"Pulmonary embolism in pregnancy: comparison of pulmonary CT angiography and lung scintigraphy","volume":"193","author":"Ridge","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"R31-20230911","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1097\/AOG.0b013e3181a99def","article-title":"Diagnosing pulmonary embolism in pregnancy using computed-tomographic angiography or ventilation-perfusion","volume":"114","author":"Cahill","year":"2009","journal-title":"Obstet Gynecol"},{"key":"R32-20230911","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.2214\/AJR.09.3506","article-title":"Pulmonary embolism in pregnancy: CT pulmonary angiography versus perfusion scanning","volume":"195","author":"Shahir","year":"2010","journal-title":"AJR Am J Roentgenol"}],"container-title":["Clinical Obstetrics &amp; Gynecology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00003081-201806000-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T08:12:48Z","timestamp":1694419968000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003081-201806000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/grf.0000000000000366","relation":{},"ISSN":["0009-9201"],"issn-type":[{"value":"0009-9201","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]}}}