{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:35:37Z","timestamp":1790847337553,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>The aim of this study was to provide a brief overview on the background and rationale on treating fetuses and children suffering from osteogenesis imperfecta (OI) with mesenchymal stem cells (MSCs). MSCs ability to migrate, engraft, and differentiate into bone cells and to act via paracrine effects on the recipient\u2019s tissues makes these cells promising candidates as a clinical therapy for OI. Animal work and limited clinical studies in humans support the use of MSC in treating OI. Off-the-shelf MSC have a good safety profile and exhibit multilineage differentiation potential and a low immunogenic profile and thereby may enable this potential therapy to become widely available. MSC transplantation before and after birth to treat OI is an experimental therapy that is currently tested in the international multicentre phase I\/II clinical trial BOOSTB4 that aims to assess the safety and efficacy of fetal MSC transplantation for the treatment of severe types of OI.<\/jats:p>","DOI":"10.1097\/grf.0000000000000656","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T16:00:27Z","timestamp":1631462427000},"page":"898-903","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":17,"title":["Mesenchymal Stem Cell Therapy for Osteogenesis Imperfecta"],"prefix":"10.1097","volume":"64","author":[{"given":"Cecilia","family":"G\u00f6therstr\u00f6m","sequence":"first","affiliation":[{"name":"Clinical Science, Intervention and Technology (CLINTEC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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